Nuclear factor-κB/Bcl-XL pathway is involved in the protective effect of hydrogen-rich saline on the brain following experimental subarachnoid hemorrhage in rabbits.

This animal study examined Nuclear factor-κB/Bcl-XL pathway is involved in the protective effect of hydrogen-rich saline on the brain following experimental subarachnoid hemorrhage in rabbits. The abstract describes Rabbit model; hydrogen delivered as hydrogen-rich saline. The abstract reports: Correspondingly, TUNEL staining demonstrated obvious neuronal apoptosis following SAH. This is an automated editorial draft based on the abstract and requires source review before publication.

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Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines.

This animal study examined Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: Here, we found that HS treatment significantly reduced infarct volume and improved neurobehavioral outcomes at 24h, 48h and 72h after pMCAO operation in a…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression.

This animal study examined Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression. The abstract describes Rat model. The abstract reports: Behaviorally, rats in the lactulose administration group won higher neurological scores and showed shorter escape latency time in the Morris test. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen alleviated organ injury and dysfunction in sepsis: The role of cross-talk between autophagy and endoplasmic reticulum stress: Experimental research.

This animal study examined Hydrogen alleviated organ injury and dysfunction in sepsis: The role of cross-talk between autophagy and endoplasmic reticulum stress: Experimental research. The abstract describes Mouse model; sample size 6. The abstract reports: Hydrogen provided protection from organ injury induced by sepsis via autophagy activation and endoplasmic reticulum stress pathway inactivation. This is an automated editorial draft based on the abstract and requires source review before publication.

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Role of Molecular Hydrogen in Skin Diseases and its Impact in Beauty.

This uncontrolled human study examined Role of Molecular Hydrogen in Skin Diseases and its Impact in Beauty. The abstract describes Human participants. The abstract reports: In today's society, healthy skin and a beautiful appearance are considered the foundation of general well-being. This is an automated editorial draft based on the abstract and requires source review before publication.

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Molecular hydrogen: current knowledge on mechanism in alleviating free radical damage and diseases

This narrative review examined Molecular hydrogen: current knowledge on mechanism in alleviating free radical damage and diseases. The abstract describes Published literature review. The abstract reports: All these pathological damages are concomitant with overproduction of reactive oxygen species (ROS) where molecular hydrogen has been widely demonstrated as a selective antioxidant. This is an automated editorial draft based on the abstract and requires source review before publication.

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Effects of hydrogen-rich saline on rats with acute carbon monoxide poisoning.

This animal study examined Effects of hydrogen-rich saline on rats with acute carbon monoxide poisoning. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: H(2)-rich saline may effectively protect the brain from injury after acute CO poisoning. The mechanism of this protection may be related to lessening oxidative…. This is an automated editorial draft based on the abstract and requires source review before publication.

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[Protective effect of hydrogen-rich water on oxidative stress cell model and the impact of the phosphatidylinositol 3 kinase/protein kinase B pathway].

This animal study examined [Protective effect of hydrogen-rich water on oxidative stress cell model and the impact of the phosphatidylinositol 3 kinase/protein kinase B pathway]. The abstract describes Mouse model; hydrogen delivered as hydrogen water; reported duration 20 minutes. The abstract reports: Hydrogen-rich water activates the PI3K/Akt pathway, thereby mediates mice astrocytes to exert the biological function of antioxidant. This is an automated editorial draft based on the abstract and requires source review before publication.

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Inhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by Protecting Spinal Cord Neurons from Apoptosis, Oxidative Injury and Mitochondrial Structure Damages.

This animal study examined Inhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by Protecting Spinal Cord Neurons from Apoptosis, Oxidative Injury and Mitochondrial Structure Damages. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation; reported duration 42 days. The abstract reports: Hydrogen inhalation (75%) ameliorated SCI in vivo and attenuated neuronal mechanical injuries in vitro, and its protective effect on spinal cord neurons was exerted…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-Rich Saline Attenuates Brain Injury Induced by Cardiopulmonary Bypass and Inhibits Microvascular Endothelial Cell Apoptosis Via the PI3K/Akt/GSK3β Signaling Pathway in Rats.

This animal study examined Hydrogen-Rich Saline Attenuates Brain Injury Induced by Cardiopulmonary Bypass and Inhibits Microvascular Endothelial Cell Apoptosis Via the PI3K/Akt/GSK3β Signaling Pathway in Rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: The PI3K/Akt/GSK3β signaling pathway plays an important role in the mechanism of CPB-induced brain injury. HRS can reduce CPB-induced brain injury and inhibit CMEC…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis.

This animal study examined Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis. The abstract describes Mouse model; reported duration 60 min. The abstract reports: CLP mice showed obvious brain injury characterized by aggravated pathological damage, BBB disruption and brain edema at 24h after CLP operation, which was markedly…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway.

This uncontrolled human study examined Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway. The abstract describes Human participants. The abstract reports: The results of MTT indicated that H2 and RAP could increase cell viability after OGD/R treatment, while 3-MA further aggravated injury and inhibited the…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Protective effects of molecular hydrogen on hepatotoxicity induced by sub-chronic exposure to chlorpyrifos in rats.

This animal study examined Protective effects of molecular hydrogen on hepatotoxicity induced by sub-chronic exposure to chlorpyrifos in rats. The abstract describes Rat model; hydrogen delivered as hydrogen water; reported duration 8 weeks. The abstract reports: The results obtained suggest that HRW intake can protect rats from CPF induced hepatotoxicity, and the oxidative stress signaling and the mitochondrial pathway may…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity.

This uncontrolled human study examined Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity. The abstract describes Human participants. The abstract reports: Trans-peritoneal administration of H2 reduces peritoneal and systemic OS. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-Rich Saline Attenuates Acute Hepatic Injury in Acute Necrotizing Pancreatitis by Inhibiting Inflammation and Apoptosis, Involving JNK and p38 Mitogen-Activated Protein Kinase-dependent Reactive Oxygen Species.

This animal study examined Hydrogen-Rich Saline Attenuates Acute Hepatic Injury in Acute Necrotizing Pancreatitis by Inhibiting Inflammation and Apoptosis, Involving JNK and p38 Mitogen-Activated Protein Kinase-dependent Reactive Oxygen Species. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: Hydrogen-rich saline plays a protective role in ANP-induced AHI through inhibiting inflammation and apoptosis, involving JNK and p38 MAPK-dependent reactive oxygen species. This is an automated editorial draft based on the abstract and requires source review before publication.

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