Hydrogen gas alleviates acute ethanol-induced hepatotoxicity in mice via modulating TLR4/9 innate immune signaling and pyroptosis.
This animal study examined Hydrogen gas alleviates acute ethanol-induced hepatotoxicity in mice via modulating TLR4/9 innate immune signaling and pyroptosis. The abstract describes Mouse model. The abstract reports: Our results showed that intraperitoneal injection of H improved acute ethanol-induced liver injury in mice in a dose dependent manner, as indicated by decreasing…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreLong-term and daily use of molecular hydrogen induces reprogramming of liver metabolism in rats by modulating NADP/NADPH redox pathways.
This animal study examined Long-term and daily use of molecular hydrogen induces reprogramming of liver metabolism in rats by modulating NADP/NADPH redox pathways. The abstract describes Rat model. The abstract reports: Rats exposed 2 h daily to H either by drinking HRW (H dissolved in HO) or by breathing 4% H gas showed reduced lipogenesis and…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreBiological Effects of Hydrogen Water on Subjects with NAFLD: A Randomized, Placebo-Controlled Trial.
This randomized controlled trial examined Biological Effects of Hydrogen Water on Subjects with NAFLD: A Randomized, Placebo-Controlled Trial. The abstract describes Human participants; sample size 30; hydrogen delivered as hydrogen water. The abstract reports: The favorable trends in this study in conjunction with previous animal and clinical findings suggest that HRW may serve as an important adjuvant therapy…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreA Preliminary Study on the Effect of Hydrogen Gas on Alleviating Early CCl4-Induced Chronic Liver Injury in Rats
This animal study examined A Preliminary Study on the Effect of Hydrogen Gas on Alleviating Early CCl4-Induced Chronic Liver Injury in Rats. The abstract describes Rat model; sample size 32. The abstract reports: We found that CCl can induce significant steatosis in hepatocytes. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling.
This in vitro or cellular study examined Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling. The abstract describes Cell culture / in vitro model; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreRenal replacement strategies: dual benefits of hydrogen gas inhalation and hydrogen-enriched dialysate.
This uncontrolled human study examined Renal replacement strategies: dual benefits of hydrogen gas inhalation and hydrogen-enriched dialysate. The abstract describes Human participants; sample size 11; hydrogen delivered as hydrogen inhalation and injected or infused hydrogen. The abstract reports: Emerging clinical evidence suggests that combining H2 gas inhalation and RRT using H2-enriched dialysate may enhance the management of oxidative stress and inflammation in…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreReduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water.
This uncontrolled human study examined Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water. The abstract describes Human participants; reported duration 1 month. The abstract reports: This study demonstrates that hemodialysis with ERW administration may efficiently increase the H2O2- and HOCl-dependent antioxidant defense and reduce H2O2- and HOCl-induced oxidative stress. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreTherapeutic effect of hydrogen and its mechanisms in kidney disease treatment.
Hydrogen is a simple, colorless, and biologically active small molecule gas that can react with reactive oxygen species. Recent research suggests that hydrogen possesses several biological effects, including antioxidant, anti-inflammatory, and anti-apoptotic effects, while exhibiting an extremely high level of safety. Hydrogen application has shown promise in treating a range of acute and chronic diseases, both benign and malignant.
Read MoreProtective effects of hydrogen-rich saline against renal ischemia-reperfusion injury by increased expression of heme oxygenase-1 in aged rats.
This animal study examined Protective effects of hydrogen-rich saline against renal ischemia-reperfusion injury by increased expression of heme oxygenase-1 in aged rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: HRS improves the renal response to I/R in aged rats, possibly by reducing oxidative stress and upregulating HO-1 gene expression. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen protects against chronic intermittent hypoxia induced renal dysfunction by promoting autophagy and alleviating apoptosis.
This animal study examined Hydrogen protects against chronic intermittent hypoxia induced renal dysfunction by promoting autophagy and alleviating apoptosis. The abstract describes Rat model. The abstract reports: We demonstrated that rats who inhale hydrogen gas showed improved renal function, alleviated pathological damage, oxidative stress and apoptosis in CIH rats. Meanwhile, CIH-induced…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreOral hydrogen water prevents chronic allograft nephropathy in rats.
This animal study examined Oral hydrogen water prevents chronic allograft nephropathy in rats. The abstract describes Rat model; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline attenuates acute renal injury in sodium taurocholate-induced severe acute pancreatitis by inhibiting ROS and NF-κB pathway.
This animal study examined Hydrogen-rich saline attenuates acute renal injury in sodium taurocholate-induced severe acute pancreatitis by inhibiting ROS and NF-κB pathway. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: Results showed that hydrogen-rich saline attenuated the following: (1) serum Cr and BUN, (2) pancreatic and renal pathological injuries, (3) renal MDA, (4) renal…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Gas Alleviates Chronic Intermittent Hypoxia-Induced Renal Injury through Reducing Iron Overload.
This in vitro or cellular study examined Hydrogen Gas Alleviates Chronic Intermittent Hypoxia-Induced Renal Injury through Reducing Iron Overload. The abstract describes Epithelial cell model. The abstract reports: Iron-induced oxidative stress has been found to be a central player in the pathogenesis of kidney injury. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline ameliorates renal injury induced by unilateral ureteral obstruction in rats.
This animal study examined Hydrogen-rich saline ameliorates renal injury induced by unilateral ureteral obstruction in rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline; reported duration 10 days. The abstract reports: Hydrogen has been demonstrated to have effective protection against tissue injuries caused by oxidative stress, inflammation, and apoptosis. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MorePretreatment with hydrogen-rich saline reduces the damage caused by glycerol-induced rhabdomyolysis and acute kidney injury in rats.
This animal study examined Pretreatment with hydrogen-rich saline reduces the damage caused by glycerol-induced rhabdomyolysis and acute kidney injury in rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: Pretreatment by HRS ameliorated renal dysfunction in glycerol-induced rhabdomyolysis by inhibiting oxidative stress and the inflammatory response. This is an automated editorial draft based on the abstract and requires source review before publication.
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