Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation.
This uncontrolled human study examined Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation. The abstract describes Human participants; hydrogen delivered as hydrogen-rich saline. The abstract reports: Hydrogen can attenuate severe burn-induced early AKI; the mechanisms of protection include the inhibition of oxidative stress induced apoptosis and inflammation, which may be…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreDual Gas Treatment With Hydrogen and Carbon Monoxide Attenuates Oxidative Stress and Protects From Renal Ischemia-Reperfusion Injury.
This animal study examined Dual Gas Treatment With Hydrogen and Carbon Monoxide Attenuates Oxidative Stress and Protects From Renal Ischemia-Reperfusion Injury. The abstract describes Rat model; reported duration 45 minutes. The abstract reports: Dual gas inhalation decreases oxidative stress and markedly improves I-R-induced renal injury. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreInhalation of hydrogen gas ameliorates glyoxylate-induced calcium oxalate deposition and renal oxidative stress in mice.
This animal study examined Inhalation of hydrogen gas ameliorates glyoxylate-induced calcium oxalate deposition and renal oxidative stress in mice. The abstract describes Mouse model; reported duration 5 days. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury.
This in vitro or cellular study examined Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury. The abstract describes Epithelial cell model. The abstract reports: HRUW solution improved graft function and prolonged graft survival compared with simple cold storage using UW solution by protecting tubular epithelial cells from inflammation…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients.
This uncontrolled human study examined Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients. The abstract describes Human participants. The abstract reports: However, the mean proportion of reversibly oxidized albumin in outlet serum was significantly lower than that in inlet serum following the H2-HD session, whereas…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Gas Does Not Ameliorate Renal Ischemia Reperfusion Injury in a Preclinical Model.
This in vitro or cellular study examined Hydrogen Gas Does Not Ameliorate Renal Ischemia Reperfusion Injury in a Preclinical Model. The abstract describes Cell culture / in vitro model. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreApplication of Electrolyzed Hydrogen Water for Management of Chronic Kidney Disease and Dialysis Treatment-Perspective View.
This uncontrolled human study examined Application of Electrolyzed Hydrogen Water for Management of Chronic Kidney Disease and Dialysis Treatment-Perspective View. The abstract describes Human participants; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreInhalation of 4% and 67% hydrogen ameliorates oxidative stress, inflammation, apoptosis, and necroptosis in a rat model of glycerol-induced acute kidney injury
This animal study examined Inhalation of 4% and 67% hydrogen ameliorates oxidative stress, inflammation, apoptosis, and necroptosis in a rat model of glycerol-induced acute kidney injury. The abstract describes Rat model; hydrogen delivered as injected or infused hydrogen. The abstract reports: After 72 hours of glycerol injection (8 mL/kg), we found that glycerol triggered oxidative stress, inflammatory reactions, and apoptotic events. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway.
This animal study examined Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling pathway. The abstract describes Rat model; hydrogen delivered as hydrogen water; reported duration 4 weeks. The abstract reports: We found that CsA increased the levels of reactive oxygen species (ROS) and malonaldehyde (MDA), but it reduced glutathione (GSH) and superoxide dismutase (SOD)…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreOral Hydrogen-Rich Water Alleviates Oxalate-Induced Kidney Injury by Suppressing Oxidative Stress, Inflammation, and Fibrosis.
This animal study examined Oral Hydrogen-Rich Water Alleviates Oxalate-Induced Kidney Injury by Suppressing Oxidative Stress, Inflammation, and Fibrosis. The abstract describes Mouse model; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffects of hydrogen-rich water in a rat model of polycystic kidney disease
This observational study examined Effects of hydrogen-rich water in a rat model of polycystic kidney disease. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: This experiment showed that the effect of drinking large volumes of hydrogen-rich water was not significantly different from that of normal water, in terms…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen nanobubble water reduces cochlear inflammation and oxidative stress in noise-induced hearing loss via the gut-inner ear axis.
This animal study examined Hydrogen nanobubble water reduces cochlear inflammation and oxidative stress in noise-induced hearing loss via the gut-inner ear axis. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: Increasing evidence suggests that environmental stress may disrupt gut microbial balance and promote inflammation that leads to distant organs, including cochlea. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreExploring the Potential of H2 Therapy in Reducing Surgical Complications: A Review on Anti-inflammatory, Antioxidant, and Anti-fibrotic Mechanisms
This review demonstrates the potential role of hydrogen in post-surgical adhesion prevention and calls for further investigation of its molecular pathways, as well as clinical studies to assess its efficacy and safety in a therapeutic setting. PubMed and Google Scholar were extensively queried to investigate the potential role of hydrogen in preventing post-surgical adhesions and its underlying mechanisms. Molecular hydrogen exhibits selective antioxidant, anti-inflammatory, and anti-fibrotic properties, holding potential for the treatment and prevention of various disorders, including acute pancreatitis, respiratory diseases, and ischemia-reperfusion damage conditions, among others.
Read MoreMolecular hydrogen as a novel regulator of cellular pyroptosis: mechanistic insights and therapeutic implications
Pyroptosis, a highly inflammatory programmed cell death pathway, drives pathogenesis in numerous diseases through gasdermin-mediated membrane pore formation and massive cytokine release. While conventional anti-inflammatory therapies show limited efficacy, hydrogen emerges as a novel therapeutic agent with unique pyroptosis-regulatory capabilities. This review establishes a comprehensive mechanistic framework demonstrating that hydrogen modulates pyroptosis through interconnected pathways including direct gasdermin redox modification, mitochondrial signaling integration, and inflammasome assembly disruption.
Read MoreAlleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed hydrogen water.
This animal study examined Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed hydrogen water. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: The results suggest that EHW could suppress stress-response-associated oxidative stress and IL-1β level elevation in vivo, and that drinking of EHW is effective for controlling…. This is an automated editorial draft based on the abstract and requires source review before publication.
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