Molecular hydrogen regulates PTEN‐AKT‐mTOR signaling via ROS to alleviate peritoneal dialysis‐related peritoneal fibrosis
This uncontrolled human study examined Molecular hydrogen regulates PTEN‐AKT‐mTOR signaling via ROS to alleviate peritoneal dialysis‐related peritoneal fibrosis. The abstract describes Human participants; hydrogen delivered as injected or infused hydrogen. The abstract reports: Furthermore, it has been found that molecular hydrogen alleviate fibrosis by eliminating intracellular ROS and inhibiting the activation of the PTEN/AKT/mTOR pathway. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreCo-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy.
This animal study examined Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation. The abstract reports: In this study, we found that hydrogen improved cardiac dysfunction and abnormal morphological structure in streptozotocin-induced diabetic mice. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen improves glycemic control in type1 diabetic animal model by promoting glucose uptake into skeletal muscle.
This animal study examined Hydrogen improves glycemic control in type1 diabetic animal model by promoting glucose uptake into skeletal muscle. The abstract describes Mouse model. The abstract reports: The results show that H(2) promoted 2-[(14)C]-deoxy-d-glucose (2-DG) uptake into C2C12 cells via the translocation of glucose transporter Glut4 through activation of phosphatidylinositol-3-OH kinase…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage.
This in vitro or cellular study examined Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage. The abstract describes Fibroblast model. The abstract reports: The results revealed that both mannitol and high glucose could cause oxidative stress in HSFs. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents.
This in vitro or cellular study examined Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents. The abstract describes HaCaT keratinocyte model. The abstract reports: Nanoparticle tracking analysis showed that fresh HW contains 1.17 × 10/mL of nano-sized hydrogen bubbles. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice.
This in vitro or cellular study examined Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. The abstract describes Fibroblast model. The abstract reports: To examine how drinking H(2)-water improves obesity and metabolic parameters at the molecular level, we examined gene-expression profiles, and found enhanced expression of a…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreTherapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress.
This animal study examined Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress. The abstract describes Rat model; hydrogen delivered as injected or infused hydrogen. The abstract reports: Hydrogen saturated saline may improve the insulin resistance and alleviate the symptoms of diabetes mellitus by reducing the oxidative stress and enhancing the anti-oxidant…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen improves type 2 diabetes through inhibiting oxidative stress.
This animal study examined Molecular hydrogen improves type 2 diabetes through inhibiting oxidative stress. The abstract describes Rat model; hydrogen delivered as injected or infused hydrogen; reported duration 4 weeks. The abstract reports: The results showed that in rats with T2DM, molecular hydrogen treatment decreased fasting blood glucose levels, increased hepatic glycogen synthesis and improved insulin sensitivity. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreSilicon nanoparticles for oral administration of molecular hydrogen.
This animal study examined Silicon nanoparticles for oral administration of molecular hydrogen. The abstract describes Animal model. The abstract reports: Silicon particles are suggested for oral administration with the ability to undergo a redox reaction with water to produce Hin vivo. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAdjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet’s Disease and Sjögren’s Syndrome: A Case Report.
This case report or case series examined Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet’s Disease and Sjögren’s Syndrome: A Case Report. The abstract describes Human participants; hydrogen delivered as injected or infused hydrogen. The abstract reports: Molecular hydrogen may aid refractory oral ulcers in Behçet's and primary Sjögren's syndromes, with clinical and immunologic benefits. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreSimultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents.
This animal study examined Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents. The abstract describes Mouse model. The abstract reports: We first examined the H2 concentrations in blood and organs after its administration and found that oral intake of HRW rapidly but transiently increased…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEfficacy of Oral Intake of Hydrogen-Rich Jelly Intake on Gingival Inflammation: A Double-Blind, Placebo-Controlled and Exploratory Randomized Clinical Trial.
This randomized controlled trial examined Efficacy of Oral Intake of Hydrogen-Rich Jelly Intake on Gingival Inflammation: A Double-Blind, Placebo-Controlled and Exploratory Randomized Clinical Trial. The abstract describes Human participants; reported duration 14 days. The abstract reports: However, no significant differences were found between groups ( > 0.05). : Administration of hydrogen-rich jelly for 14 days decreased gingival inflammation. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreUsing oral molecular hydrogen supplements to combat microinflammation in humans: a pilot observational study.
This observational study examined Using oral molecular hydrogen supplements to combat microinflammation in humans: a pilot observational study. The abstract describes Human participants; hydrogen delivered as hydrogen water; reported duration 4 weeks. The abstract reports: Compared to HRW and CaH, OSHCs demonstrated a prolonged reduction in ORP for 60 minutes in vitro and enabled a regulated release of hydrogen…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner.
This animal study examined Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner. The abstract describes Mouse model. The abstract reports: Finally, we found that H improved survival rates and brain dysfunction and decreased inflammatory cytokines. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen ameliorates chronic intermittent hypoxia-induced neurocognitive impairment via inhibiting oxidative stress.
This uncontrolled human study examined Hydrogen ameliorates chronic intermittent hypoxia-induced neurocognitive impairment via inhibiting oxidative stress. The abstract describes Human participants; reported duration 5 weeks. The abstract reports: Our results showed that H treatment improved the CIH-induced spatial learning and memory impairments. This is an automated editorial draft based on the abstract and requires source review before publication.
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