Prophylactic Instillation of Hydrogen-Rich Water Decreases Corneal Inflammation and Promotes Wound Healing by Activating Antioxidant Activity in a Rat Alkali Burn Model.
This animal study examined Prophylactic Instillation of Hydrogen-Rich Water Decreases Corneal Inflammation and Promotes Wound Healing by Activating Antioxidant Activity in a Rat Alkali Burn Model. The abstract describes Rat model; hydrogen delivered as hydrogen water; reported duration 5 min. The abstract reports: Many studies have demonstrated the therapeutic effects of hydrogen in pathological conditions such as inflammation; however, little is known about its prophylactic effects. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAntioxidant Activity of Hydrogen Water Mask Pack Composed of Gel-Type Emulsion and Hydrogen Generation Powder.
This uncontrolled human study examined Antioxidant Activity of Hydrogen Water Mask Pack Composed of Gel-Type Emulsion and Hydrogen Generation Powder. The abstract describes Human participants; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs.
This animal study examined The Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs. The abstract describes Animal model; hydrogen delivered as hydrogen water and topical hydrogen. The abstract reports: We observed that HRW wounds showed an increased rate of wound healing, and a faster average healing time compared with DW. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline reduces tissue injury and improves skin flap survival on a rat hindlimb degloving injury model.
This animal study examined Hydrogen-rich saline reduces tissue injury and improves skin flap survival on a rat hindlimb degloving injury model. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline; reported duration 5 days. The abstract reports: Repeated HRS injections after trauma increased the viability of skin flap in rat degloving injury model by decreasing local tissue injury, due to its…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe protective effects of molecular hydrogen in sepsis-associated encephalopathy: current status.
Sepsis-associated encephalopathy (SAE) is a severe neurological complication that arises in patients with sepsis, characterised by cognitive impairment and neurological dysfunction. Mechanisms contributing to SAE include oxidative stress, inflammation, mitochondrial dysfunction, and blood-brain barrier disruption. Recent studies indicate that molecular hydrogen (H2) offers therapeutic benefits for SAE due to its antioxidant and anti-inflammatory properties.
Read MorePostconditioning with inhaled hydrogen attenuates skin ischemia/reperfusion injury through the RIP-MLKL-PGAM5/Drp1 necrotic pathway.
This animal study examined Postconditioning with inhaled hydrogen attenuates skin ischemia/reperfusion injury through the RIP-MLKL-PGAM5/Drp1 necrotic pathway. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation. The abstract reports: In the SH and HCH groups, the necrotic factors measured here showed similar expression levels, which were significantly lower than the levels in the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen-mediated SIRT1 activation alleviates sepsis-associated encephalopathy by promoting mitophagy
This animal study examined Molecular hydrogen-mediated SIRT1 activation alleviates sepsis-associated encephalopathy by promoting mitophagy. The abstract describes Mouse model. The abstract reports: This study demonstrates that inhalation of 2% H2 exerts significant protective effects against SAE, in which SIRT1 plays a pivotal role by modulating PINK1-dependent…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway.
This in vitro or cellular study examined Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway. The abstract describes Cell culture / in vitro model; hydrogen delivered as hydrogen inhalation. The abstract reports: Sepsis-associated encephalopathy (SAE) is the cognitive impairment resulting from sepsis and is associated with increased morbidity and mortality. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreChronic molecular hydrogen inhalation mitigates short and long-term memory loss in polymicrobial sepsis.
This uncontrolled human study examined Chronic molecular hydrogen inhalation mitigates short and long-term memory loss in polymicrobial sepsis. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: Our results indicate that (1) chronic exposure of hydrogen gas is a simple, safe and promising therapeutic strategy to prevent memory loss in patients…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAug 2019(mitochondrial dysfunction ,sepsis, autophagy)Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy-mediated NLRP3 inflammasome inactivation in sepsis
This animal study examined Aug 2019(mitochondrial dysfunction ,sepsis, autophagy)Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy-mediated NLRP3 inflammasome inactivation in sepsis. The abstract describes Mouse model. The abstract reports: The results demonstrated that LPS and ATP led to NLRP3 inflammasome pathway activation, excessive cytokine release, mitochondrial dysfunction and the activation of autophagy. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas presents a promising therapeutic strategy for sepsis.
This uncontrolled human study examined Hydrogen gas presents a promising therapeutic strategy for sepsis. The abstract describes Human participants. The abstract reports: Recently, some studies have found that molecular hydrogen is a new therapeutic gas. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-Rich Saline Regulates Intestinal Barrier Dysfunction, Dysbiosis, and Bacterial Translocation in a Murine Model of Sepsis.
This animal study examined Hydrogen-Rich Saline Regulates Intestinal Barrier Dysfunction, Dysbiosis, and Bacterial Translocation in a Murine Model of Sepsis. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline; reported duration 7 days. The abstract reports: In the results, the 7-day survival rate was significantly improved in the H2 group versus the control group (69% vs. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Gas Protects Against Intestinal Injury in Wild Type But Not NRF2 Knockout Mice With Severe Sepsis by Regulating HO-1 and HMGB1 Release.
This animal study examined Hydrogen Gas Protects Against Intestinal Injury in Wild Type But Not NRF2 Knockout Mice With Severe Sepsis by Regulating HO-1 and HMGB1 Release. The abstract describes Mouse model. The abstract reports: The results showed that therapy with 2% H2 increased the survival rate, alleviated the injuries caused by oxidative stress and inflammation, reduced HMGB1 levels…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release.
This uncontrolled human study examined Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. The abstract describes Human participants. The abstract reports: Recently, it has been suggested that molecular hydrogen (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radicals (*OH, the most cytotoxic reactive…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreA review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine.
Hydrogen is the most abundant chemical element in the Universe, but is seldom regarded as a therapeutic agent. Recent evidence has shown that hydrogen is a potent antioxidative, antiapoptotic and anti-inflammatory agent and so may have potential medical applications in cells, tissues and organs. There are several methods to administer hydrogen, such as inhalation of hydrogen gas, aerosol inhalation of a hydrogen-rich solution, drinking hydrogen dissolved in water, injecting hydrogen-rich saline (HRS) and taking a hydrogen bath.
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