Hydrogen attenuated oxidized low-density lipoprotein-induced inflammation through the stimulation of autophagy via sirtuin 1.
This in vitro or cellular study examined Hydrogen attenuated oxidized low-density lipoprotein-induced inflammation through the stimulation of autophagy via sirtuin 1. The abstract describes Cell culture / in vitro model. The abstract reports: Hydrogen has been demonstrated to serve a protective role in diverse models of disease. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreResearch Progress of Hydrogen on Chronic Nasal Inflammation.
Chronic nasal mucosal inflammatory disease is a common nasal disease, which is involved by inflammatory cells and a variety of cytokines. Its main pathological features are inflammatory reaction, increased secretion, mucosal swelling and thickening of nasal cavity or paranasal sinuses.It mainly includes chronic rhinitis (divided into allergic rhinitis, non-allergic rhinitis), chronic sinusitis (divided into with nasal polyps, without nasal polyps type), etc.The main symptoms of chronic rhinitis are nasal itching, sneezing, runny nose, and nasal congestion. The main symptoms of chronic sinusitis are nasal congestion, purulent or sticky nasal discharge,…
Read MoreMolecular hydrogen as a novel regulator of cellular pyroptosis: mechanistic insights and therapeutic implications
Pyroptosis, a highly inflammatory programmed cell death pathway, drives pathogenesis in numerous diseases through gasdermin-mediated membrane pore formation and massive cytokine release. While conventional anti-inflammatory therapies show limited efficacy, hydrogen emerges as a novel therapeutic agent with unique pyroptosis-regulatory capabilities. This review establishes a comprehensive mechanistic framework demonstrating that hydrogen modulates pyroptosis through interconnected pathways including direct gasdermin redox modification, mitochondrial signaling integration, and inflammasome assembly disruption.
Read MoreAlleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed hydrogen water.
This animal study examined Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed hydrogen water. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: The results suggest that EHW could suppress stress-response-associated oxidative stress and IL-1β level elevation in vivo, and that drinking of EHW is effective for controlling…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MorePotent anti-inflammatory responses: Role of hydrogen in IL-1α dominated early phase systemic inflammation.
This animal study examined Potent anti-inflammatory responses: Role of hydrogen in IL-1α dominated early phase systemic inflammation. The abstract describes Mouse model. The abstract reports: The results suggested that hydrogen is potentially inhibitive against inflammation by inhibiting HIF-1α and IL-1α release at early occurrence. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline attenuates eosinophil activation in a guinea pig model of allergic rhinitis via reducing oxidative stress
This animal study examined Hydrogen-rich saline attenuates eosinophil activation in a guinea pig model of allergic rhinitis via reducing oxidative stress. The abstract describes Animal model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: HRS may play a protective role in attenuating allergic inflammation, and suppressing the increase and activation of eosinophils in AR possibly through antioxidation effect…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas improves survival rate and organ damage in zymosan-induced generalized inflammation model.
This uncontrolled human study examined Hydrogen gas improves survival rate and organ damage in zymosan-induced generalized inflammation model. The abstract describes Human participants; reported duration 60 min. The abstract reports: Recently, it has been suggested that hydrogen gas (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical (•OH, the most cytotoxic reactive…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffect of molecular hydrogen on uterine inflammation during preterm labour.
This animal study examined Effect of molecular hydrogen on uterine inflammation during preterm labour. The abstract describes Mouse model. The abstract reports: Our previous studies demonstrated that molecular hydrogen (H), an anti-inflammatory agent, prevented inflammation-induced impairment in foetal brain and lung tissues in lipopolysaccharide (LPS)-induced rodent…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreCombating Oxidative Stress and Inflammation in COVID-19 by Molecular Hydrogen Therapy: Mechanisms and Perspectives.
This narrative review examined Combating Oxidative Stress and Inflammation in COVID-19 by Molecular Hydrogen Therapy: Mechanisms and Perspectives. The abstract describes Published literature review. The abstract reports: This situation results in impaired gas exchange, hypoxia, and other sequelae that lead to multisystem organ failure and death. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreH2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain.
This animal study examined H2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. The abstract describes Rat model. The abstract reports: We found that H2 clearly inhibited hyperalgesia and allodynia in neuropathic pain and also attenuated the pro-inflammatory cytokines TNF-α, IL-1β, and high-mobility group box…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreIn Situ Nanoreactor for Photosynthesizing H Gas To Mitigate Oxidative Stress in Tissue Inflammation.
This animal study examined In Situ Nanoreactor for Photosynthesizing H Gas To Mitigate Oxidative Stress in Tissue Inflammation. The abstract describes Mouse model. The abstract reports: Experimental results indicate that the Lip NR system that can photosynthesize H gas has great potential for mitigating oxidative stress in tissue inflammation. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe immunological effects of electrolyzed reduced water on the Echinostoma hortense infection in C57BL/6 mice.
This animal study examined The immunological effects of electrolyzed reduced water on the Echinostoma hortense infection in C57BL/6 mice. The abstract describes Mouse model. The abstract reports: In the case of infected groups, the group fed ERW (ERW+E. hortense group) showed the result that IL-4, IL-5, IL-10 and Ig A expression…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAnti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema.
This in vitro or cellular study examined Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema. The abstract describes Cell culture / in vitro model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: As a more convenient way than inhaling H2, hydrogen saline exhibits a protective effect against inflammation and it might provide a novel therapeutic approach…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen increases resilience to stress in mice.
This animal study examined Molecular hydrogen increases resilience to stress in mice. The abstract describes Mouse model; hydrogen delivered as oxyhydrogen. The abstract reports: The results showed that repeated inhalation of hydrogen-oxygen mixed gas [67%:33% (V/V)] significantly decreased both the acute and chronic stress-induced depressive- and anxiety-like behaviors…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators.
This in vitro or cellular study examined Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators. The abstract describes Cell culture / in vitro model. The abstract reports: We previously showed that H2 acts as a novel antioxidant to protect cells against oxidative stress. This is an automated editorial draft based on the abstract and requires source review before publication.
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