Combination therapy of molecular hydrogen and hyperoxia improves survival rate and organ damage in a zymosan-induced generalized inflammation model

This uncontrolled human study examined Combination therapy of molecular hydrogen and hyperoxia improves survival rate and organ damage in a zymosan-induced generalized inflammation model. The abstract describes Human participants. The abstract reports: The results showed that the inhalation of H (2%) or hyperoxia (98%) alone improved the 14-day survival rate of ZY-challenged mice from 20 to…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Impact of molecular hydrogen treatments on the innate immune activity and survival of zebrafish (Danio rerio) challenged with Aeromonas hydrophila.

This animal study examined Impact of molecular hydrogen treatments on the innate immune activity and survival of zebrafish (Danio rerio) challenged with Aeromonas hydrophila. The abstract describes Zebrafish model; hydrogen delivered as hydrogen water. The abstract reports: We have found an increased survival rate of bacteria-challenged zebrafish subjected to the HRW immersion treatment. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate.

This animal study examined Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. The abstract describes Mouse model. This is an automated editorial draft based on the abstract and requires source review before publication.

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Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages.

This in vitro or cellular study examined Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages. The abstract describes Cell culture / in vitro model. The abstract reports: Molecular hydrogen exerts a regulating role in the release of pro- and anti-inflammatory cytokines in LPS-stimulated macrophages, and this effect is at least partly…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-rich saline resuscitation alleviates inflammation induced by severe burn with delayed resuscitation.

This animal study examined Hydrogen-rich saline resuscitation alleviates inflammation induced by severe burn with delayed resuscitation. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: We found that resuscitation by hydrogen-rich saline alleviated inflammation significantly. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-Rich Saline Ameliorates Allergic Rhinitis by Reversing the Imbalance of Th1/Th2 and Up-Regulation of CD4+CD25+Foxp3+Regulatory T Cells, Interleukin-10, and Membrane-Bound Transforming Growth Factor-β in Guinea Pigs

This animal study examined Hydrogen-Rich Saline Ameliorates Allergic Rhinitis by Reversing the Imbalance of Th1/Th2 and Up-Regulation of CD4+CD25+Foxp3+Regulatory T Cells, Interleukin-10, and Membrane-Bound Transforming Growth Factor-β in Guinea Pigs. The abstract describes Animal model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. This is an automated editorial draft based on the abstract and requires source review before publication.

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Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells.

Molecular hydrogen ameliorates oxidative stress-associated diseases in animal models. We found that oral intake of hydrogen-rich water abolishes an immediate-type allergic reaction in mice. Using rat RBL-2H3 mast cells, we demonstrated that hydrogen attenuates phosphorylation of the FcepsilonRI-associated Lyn and its downstream signal transduction, which subsequently inhibits the NADPH oxidase activity and reduces the generation of hydrogen peroxide.

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Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch.

This uncontrolled human study examined Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch. The abstract describes Human participants. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-rich water improves endurance by reducing skeletal muscle oxidative stress and inflammatory responses.

This animal study examined Hydrogen-rich water improves endurance by reducing skeletal muscle oxidative stress and inflammatory responses. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: Mice that consumed HRW for ≥P4 weeks ran significantly longer distances, showed less muscle fatigue, and had lower levels of markers of oxidative stress,…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen Gas via Extracorporeal Membrane Oxygenation and Its Effects on Oxidative Stress, Coagulation, and Inflammation: An Ex Vivo Model.

This uncontrolled human study examined Hydrogen Gas via Extracorporeal Membrane Oxygenation and Its Effects on Oxidative Stress, Coagulation, and Inflammation: An Ex Vivo Model. The abstract describes Human participants; sample size 4; reported duration 6 hours. The abstract reports: Hydrogen exposure significantly reduced collagen (p = 0.01), TRAP-6 (p = 0.04), and ADP-induced (p = 0.04) platelet aggregation and showed a trend toward…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Molecular Hydrogen Therapy for SLE-PAH: Case Report on Immune Marker Modulation

Systemic lupus erythematosus-associated pulmonary arterial hypertension (SLE-PAH) is a severe complication marked by elevated pulmonary artery pressure, leading to exertional dyspnea and right-sided heart failure. Standard treatments frequently fall short in effectively controlling symptoms, highlighting the need for innovative therapeutic approaches. This aim of this study was to investigate the efficacy of molecular hydrogen therapy in a patient with SLE-PAH with decompensated right-side heart failure.

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Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum.

This uncontrolled human study examined Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum. The abstract describes Human participants; hydrogen delivered as hydrogen bath. This is an automated editorial draft based on the abstract and requires source review before publication.

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Effects of Hydrogen-Rich Water on Growth, Redox Homeostasis and Hormonal, Histological and Immune Systems in Rats Exposed to High Cage Density Stress.

This animal study examined Effects of Hydrogen-Rich Water on Growth, Redox Homeostasis and Hormonal, Histological and Immune Systems in Rats Exposed to High Cage Density Stress. The abstract describes Rat model; hydrogen delivered as hydrogen water; reported duration 3 months. The abstract reports: The stress-related physiological parameters were reduced in the HRW + stress group compared to the stress group. HRW could be suggested when the organism is found…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Nano-bubble hydrogen water: An effective therapeutic agent against inflammation related disease caused by viral infection in zebrafish model

This animal study examined Nano-bubble hydrogen water: An effective therapeutic agent against inflammation related disease caused by viral infection in zebrafish model. The abstract describes Zebrafish model; hydrogen delivered as hydrogen water. The abstract reports: The results revealed that the cumulative mortality rate of SVCV-infected zebrafish was reduced by 40% after treatment with nano-bubble hydrogen water, and qRT-PCR results…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial.

This randomized controlled trial examined Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: Flow cytometry analysis of CD4, CD8, CD20, CD14 and CD11b cells showed that the frequency of CD14 cells decreased in the HW group. This is an automated editorial draft based on the abstract and requires source review before publication.

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