Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet’s Disease and Sjögren’s Syndrome: A Case Report.

This case report or case series examined Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet’s Disease and Sjögren’s Syndrome: A Case Report. The abstract describes Human participants; hydrogen delivered as injected or infused hydrogen. The abstract reports: Molecular hydrogen may aid refractory oral ulcers in Behçet's and primary Sjögren's syndromes, with clinical and immunologic benefits. This is an automated editorial draft based on the abstract and requires source review before publication.

Read More

Efficacy of Oral Intake of Hydrogen-Rich Jelly Intake on Gingival Inflammation: A Double-Blind, Placebo-Controlled and Exploratory Randomized Clinical Trial.

This randomized controlled trial examined Efficacy of Oral Intake of Hydrogen-Rich Jelly Intake on Gingival Inflammation: A Double-Blind, Placebo-Controlled and Exploratory Randomized Clinical Trial. The abstract describes Human participants; reported duration 14 days. The abstract reports: However, no significant differences were found between groups ( > 0.05). : Administration of hydrogen-rich jelly for 14 days decreased gingival inflammation. This is an automated editorial draft based on the abstract and requires source review before publication.

Read More

Using oral molecular hydrogen supplements to combat microinflammation in humans: a pilot observational study.

This observational study examined Using oral molecular hydrogen supplements to combat microinflammation in humans: a pilot observational study. The abstract describes Human participants; hydrogen delivered as hydrogen water; reported duration 4 weeks. The abstract reports: Compared to HRW and CaH, OSHCs demonstrated a prolonged reduction in ORP for 60 minutes in vitro and enabled a regulated release of hydrogen…. This is an automated editorial draft based on the abstract and requires source review before publication.

Read More

Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner.

This animal study examined Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner. The abstract describes Mouse model. The abstract reports: Finally, we found that H improved survival rates and brain dysfunction and decreased inflammatory cytokines. This is an automated editorial draft based on the abstract and requires source review before publication.

Read More

Hydrogen‐Rich Water Improves Cognitive Ability and Induces Antioxidative, Antiapoptotic, and Anti‐Inflammatory Effects in an Acute Ischemia‐Reperfusion Injury Mouse Model

This animal study examined Hydrogen‐Rich Water Improves Cognitive Ability and Induces Antioxidative, Antiapoptotic, and Anti‐Inflammatory Effects in an Acute Ischemia‐Reperfusion Injury Mouse Model. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: Hydrogen treatment could potentially be a future therapeutic strategy for ischemia and its derived neurodegenerative diseases by improving cognitive abilities and inducing antioxidative and…. This is an automated editorial draft based on the abstract and requires source review before publication.

Read More

Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice.

This uncontrolled human study examined Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice. The abstract describes Human participants. The abstract reports: We found that 2% H inhalation can reduce pro-inflammatory factors, alleviate DNMT1, DNMT3a but not DNMT3b expression, make hypomethylation of BDNF promoter IV at…. This is an automated editorial draft based on the abstract and requires source review before publication.

Read More

Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture.

This animal study examined Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: These findings indicate that HRS could attenuate the consequences of sepsis induced by cecal ligation and puncture in rats, at least in part, by…. This is an automated editorial draft based on the abstract and requires source review before publication.

Read More

Hydrogen-Rich Saline Ameliorates Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice Via the Nrf2-ARE Signaling Pathway.

This animal study examined Hydrogen-Rich Saline Ameliorates Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice Via the Nrf2-ARE Signaling Pathway. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. The abstract reports: We found that HRS reduced the severity of EAE in mice and alleviated inflammation and demyelination. This is an automated editorial draft based on the abstract and requires source review before publication.

Read More

Molecular hydrogen inhalation attenuates postoperative cognitive impairment in rats.

This animal study examined Molecular hydrogen inhalation attenuates postoperative cognitive impairment in rats. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation. The abstract reports: Many studies have found that molecular hydrogen (H2) has significant neuroprotection against acute and chronic neurological injury by regulating inflammation and apoptosis. This is an automated editorial draft based on the abstract and requires source review before publication.

Read More

Molecular Hydrogen Modulates T Cell Differentiation and Enhances Neuro-Regeneration in a Vascular Dementia Mouse Model

This animal study examined Molecular Hydrogen Modulates T Cell Differentiation and Enhances Neuro-Regeneration in a Vascular Dementia Mouse Model. The abstract describes Mouse model; sample size 6; hydrogen delivered as hydrogen water. The abstract reports: Histological examinations showed pyknotic neuronal morphologies and elevated reactive oxygen species (ROS) in the VaD hippocampus, whereas H administration mitigated these alterations. This is an automated editorial draft based on the abstract and requires source review before publication.

Read More

Hydrogen inhalation therapy may ameliorate amyotrophic lateral sclerosis.

This uncontrolled human study examined Hydrogen inhalation therapy may ameliorate amyotrophic lateral sclerosis. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: Amyotrophic lateral sclerosis (ALS) is a motor neuron disease, a neurodegenerative disorder characterized by sporadic and progressive degenerative loss of cell bodies of both…. This is an automated editorial draft based on the abstract and requires source review before publication.

Read More

Inhaled molecular hydrogen reduces hippocampal neuroinflammation, glial reactivity and ameliorates memory impairment during systemic inflammation.

This uncontrolled human study examined Inhaled molecular hydrogen reduces hippocampal neuroinflammation, glial reactivity and ameliorates memory impairment during systemic inflammation. The abstract describes Human participants; hydrogen delivered as injected or infused hydrogen. The abstract reports: Sepsis is associated with numerous physiological and biochemical abnormalities that result in a life-threatening condition. This is an automated editorial draft based on the abstract and requires source review before publication.

Read More

Molecular hydrogen attenuates sepsis-induced cognitive dysfunction through regulation of tau phosphorylation.

This animal study examined Molecular hydrogen attenuates sepsis-induced cognitive dysfunction through regulation of tau phosphorylation. The abstract describes Mouse model. The abstract reports: The protective effect of H on cognitive dysfunction induced by SAE may be achieved by inhibiting tau phosphorylation, which is perhaps related with the…. This is an automated editorial draft based on the abstract and requires source review before publication.

Read More

Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice.

This animal study examined Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: We found that prophylactic administration of both 0.36mM and 0.89mM HRW was able to delay EAE onset and reduce maximum clinical scores. This is an automated editorial draft based on the abstract and requires source review before publication.

Read More

The Anti-Inflammatory Effect of Hydrogen Gas Inhalation and Its Influence on Laser-Induced Choroidal Neovascularization in a Mouse Model of Neovascular Age-Related Macular Degeneration

This animal study examined The Anti-Inflammatory Effect of Hydrogen Gas Inhalation and Its Influence on Laser-Induced Choroidal Neovascularization in a Mouse Model of Neovascular Age-Related Macular Degeneration. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation. The abstract reports: H inhalation could alleviate CNV leakage in a laser-induced mouse CNV model, and the potential mechanism might be related to the suppression of the…. This is an automated editorial draft based on the abstract and requires source review before publication.

Read More