Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats.

This uncontrolled human study examined Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: Lack of dose responses of hydrogen and the presence of favorable effects with hydrogen water and intermittent hydrogen gas suggest that signal modulating activities…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson’s disease

This animal study examined Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson’s disease. The abstract describes Rat model. The abstract reports: In conclusion, the PD animal model showed increased intestinal permeability together with hepatic inflammation correlated with altered gut microbiota. This is an automated editorial draft based on the abstract and requires source review before publication.

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Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson’s disease: a pilot study

This randomized controlled trial examined Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson’s disease: a pilot study. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: This pilot study revealed that the inhalation of molecular hydrogen gas was safe, but did not show any beneficial effects in patients with PD. This is an automated editorial draft based on the abstract and requires source review before publication.

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Therapeutic Effects of Hydrogen in Animal Models of Parkinson’s Disease

This in vitro or cellular study examined Therapeutic Effects of Hydrogen in Animal Models of Parkinson’s Disease. The abstract describes Cell culture / in vitro model. The abstract reports: Thus, it is strongly suggested that hydrogen might provide a great advantage to prevent or minimize the onset and progression of PD. This is an automated editorial draft based on the abstract and requires source review before publication.

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A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics.

This randomized controlled trial examined A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: Our previous randomized double-blind study showed that drinking hydrogen (H2) water for 48 weeks significantly improved the total Unified Parkinson's Disease Rating Scale (UPDRS) score…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease.

This animal study examined Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: Methamphetamine-induced behavioral analysis showed that molecular hydrogen prevented both the development and progression of the nigrostrital degeneration. This is an automated editorial draft based on the abstract and requires source review before publication.

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Pilot study of H2 therapy in Parkinson’s disease: A randomized double‐blind placebo‐controlled trial

This randomized controlled trial examined Pilot study of H2 therapy in Parkinson’s disease: A randomized double‐blind placebo‐controlled trial. The abstract describes Human participants; sample size 9; reported duration 48 weeks. The abstract reports: The results indicated that drinking H₂-water was safe and well tolerated, and a significant improvement in total UPDRS scores for patients in the H₂-water…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Inhalation of hydrogen gas elevates urinary 8-hydroxy-2′-deoxyguanine in Parkinson’s disease.

This randomized controlled trial examined Inhalation of hydrogen gas elevates urinary 8-hydroxy-2′-deoxyguanine in Parkinson’s disease. The abstract describes Human participants; sample size 20; hydrogen delivered as hydrogen water; reported duration 10 minutes. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease.

This animal study examined Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. The abstract describes Mouse model. The abstract reports: The concentration-dependency of H(2) showed that H(2) as low as 0.08 ppm had almost the same effect as saturated H(2) water (1.5 ppm). This is an automated editorial draft based on the abstract and requires source review before publication.

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Realizing brain therapy with “smart medicine”: mechanism and case report of molecular hydrogen inhalation for Parkinson’s disease.

This case report or case series examined Realizing brain therapy with “smart medicine”: mechanism and case report of molecular hydrogen inhalation for Parkinson’s disease. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation; reported duration 35 years. The abstract reports: Fox Foundation has been funding research on Parkinson's disease for 35 years, but has yet to find a cure. This is an automated editorial draft based on the abstract and requires source review before publication.

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Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases.

This narrative review examined Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases. The abstract describes Published literature review. The abstract reports: While preclinical studies demonstrate promising results, clinical trials conducted thus far have yielded mixed outcomes, with some trials reporting limited or no therapeutic benefit. This is an automated editorial draft based on the abstract and requires source review before publication.

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Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice.

This animal study examined Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice. The abstract describes Mouse model. The abstract reports: The protective effect of H water was still observed in the vagotomized mice in substantia nigra, suggesting that stimulation of vagal afferent nerves is…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: A pilot study.

This uncontrolled human study examined Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: A pilot study. The abstract describes Human participants; sample size 18; hydrogen delivered as hydrogen water. The abstract reports: This novel, proof-of-concept study demonstrated that PBM+H2 therapy is safe and reduces disease severity. A larger-scaled clinical trial is warranted to completely investigate the…. This is an automated editorial draft based on the abstract and requires source review before publication.

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