Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs.
In guinea pigs, the ABR thresholds at 2 and 4 kHz were significantly better on post-noise days 1, 3, and 14 in hydrogen-treated animals when compared to the normal water-treated controls. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MorePrevention of ischemia-induced hearing loss by intravenous administration of hydrogen-rich saline in gerbil.
In an animal model, when the animals were treated with hydrogen-rich water, cochlear damage was significantly reduced: the increase in ABR threshold was 11.7±2.6dB at 8kHz and the IHC loss was 7.5%±2.1% at the basal turn on day 7. These preclinical findings add evidence about the molecular-hydrogen effects, outcomes, and biological pathways measured in this model.
Read MoreHydrogen-rich water reduced oxidative stress and renal fibrosis in rats with unilateral ureteral obstruction.
In rats, compared with the UUO + DW group, HW administration attenuated tubulointerstitial injury and reduced interstitial fibrotic area, causing a substantial decline in the frequency of α-SMA-, ED-1-, and TGF-β1-positive cells in the UUO + HW group. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreProtective Effect of Hydrogen on Sodium Iodate-Induced Age-Related Macular Degeneration in Mice.
In mice, mechanistically, HRW greatly reduced the oxidative stress reaction through decreased MDA levels, increased SOD production, and decreased ROS content. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreMolecular hydrogen enhances osteogenesis in Danio rerio embryos.
In zebrafish embryo, hydrogen-rich water (HRW) does not affect vitality or growth rate up to 15%. The authors concluded that, the researchers demonstrated the beneficial effects of hydrogen on anabolic bone functions in vivo. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreMechanism of hydrogen-rich water alleviating radiation-induced cognitive impairment through PI3K/AKT/Caspase-9 pathway mediating anti-oxidation.
In rats, hydrogen-rich water can improve the radiation-induced cognitive impairment in rats induced by ionizing radiation through anti-inflammation, anti-oxidation, and regulation of PI3K/AKT/Caspase-9 pathway, and there is a certain dose-effect relationship. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreCombating oxidative stress and inflammation in gentamicin-induced nephrotoxicity using hydrogen-rich water.
In rats, data showed that while MDA, TNF-α, IL-6, endocan, and endoglin, urea, and creatinine parameters increased in the gentamicin group compared to the other groups, a decrease in these parameters was observed in the gentamicin+hydrogen group compared to the gentamicin group. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read More富氢水抑制离心运动后骨骼肌线粒体氧化应激和炎症反应
In Sprague Dawley rats, the study examined whether hydrogen-rich water could protect skeletal muscle from eccentric-exercise injury and explored the underlying mechanisms. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read More[Alleviating effects of hydrogen on hyperhomocysteinemia and fatty liver induced by high-methionine diet].
In Wistar rats, pathological tissue sections showed liver enlargement, injury, and fatty liver in the rats; Compared with the HMD group rats, the HMD+HRW group rats showed a significant decrease in Hcy in the blood, reduced liver damage, and increased Hcy metabolism key enzyme activity and mRNA expression in the liver, with statistical differences (P<0.05). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreZn-Fe primary battery-enabled controlled hydrogen release in stomach for improving insulin resistance in obesity-associated type 2 diabetes.
In mice, this work enhances the hydrolysis rate of Zn by constructing a Zn-Fe primary-battery micro-/nano-structure, and the H₂-releasing rate is adjusted by tuning the ratio of Zn to Fe. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreEffects of hydrogen-rich water on depressive-like behavior in mice.
In an animal model, cUMS induced elevation in IL-1β protein levels in the hippocampus, and the cortex was significantly attenuated after 4 weeks of feeding the mice hydrogen-rich water. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreColloidal platinum in hydrogen-rich water exhibits radical-scavenging activity and improves blood fluidity.
When applied with the 0.25-0.5 ppm Pt/PVP-colloid in RW or HW, the level of DPPH radicals decreased to 77.5-59.6% or 16.1-5.6%, in contrast to the level as high as 81.3% for HW alone, respectively, as measured by an electron spin resonance method. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreHydrogen activates ACOD1-itaconate pathway to ameliorate steroid-associated osteonecrosis.
In mice, HRW-treated mice exhibit improved serum lipid profiles, including decreased levels of low-density lipoprotein (LDL), triglycerides (TG), and total cholesterol (T-CHO), as well as reduced lipid accumulation. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen Rich Water Improved Ventilatory, Perceptual and Lactate Responses to Exercise.
A significantly lower blood lactate was found with HRW (4.0±1.6 and 8.9±2.2 mmol.l-1) compared to Placebo (5.1±1.9 and 10.6±3.0 mmol.l-1) at 3.0, and 4.0 W.kg-1, respectively.
Read MoreAcute effect of hydrogen-rich water on physical, perceptual and cardiac responses during aerobic and anaerobic exercises: a randomized, placebo-controlled, double-blinded cross-over trial.
In In a randomized, double-blind study design, all players ingested 500 mL of HRW or placebo (PLA) supplement 30 min before the start of the tests, 500 mL of HRW can significantly improve HRpeak, time to exhaustion, RPE, with no significant effect on MAS, jumping performance in amateur endurance athletes. These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in this study.
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