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Latest Molecular Hydrogen Articles

317 Articles

Combination of Hydrogen Inhalation and Hypothermic Temperature Control After Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care II Trial.

By H2HUBB Jul 22, 2026 0 Comments

In 72 patients, however, hydrogen + TTM32-TTM34 did not improve survival compared with TTM32-TTM34 alone (adjusted hazard ratio: 0.22 [95% CI, 0.05-1.06], p = 0.06). These findings add human evidence supporting molecular hydrogen's therapeutic potential across the specific human outcomes evaluated in…

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Influence of oxygen concentration on the neuroprotective effect of hydrogen inhalation in a rat model of cardiac arrest.

By H2HUBB Jul 22, 2026 0 Comments

In this CA rat model, inhaling 2% hydrogen combined with a high concentration of oxygen improved 96-h survival, either under normothermia or under hypothermia. These preclinical findings add…

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Hydrogen gas inhalation improves delayed brain injury by alleviating early brain injury after experimental subarachnoid hemorrhage.

By H2HUBB Jul 22, 2026 0 Comments

Time course of ICP showed no significant difference between the control (n = 35) and H₂ (n = 33) groups (at 0, peak, 10, 20 and 30 min;…

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Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via inhibition of oxidative stress.

By H2HUBB Jul 22, 2026 0 Comments

In male Wistar rats, the neuronal density 3·3±2·1 cells/mm in CA1 region of the ischemic rats increased to 21·7±2·6 cells/mm after they were treated with hydrogen gas. These…

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Efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II trial): study protocol for a randomized controlled trial.

By H2HUBB Jul 22, 2026 0 Comments

This publication examined hydrogen gas using the study design reported by the authoritative source. No study results are reported because this publication is a protocol.

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Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats.

By H2HUBB Jul 22, 2026 0 Comments

In male Sprague-Dawley rats, hydrogen gas significantly alleviated brain edema and blood-brain barrier disruption, reduced apoptosis, and improved neurologic function at 24 hrs but not 72 hrs after…

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Hydrogen-rich saline alleviates early brain injury through inhibition of necroptosis and neuroinflammation via the ROS/HO-1 signaling pathway after traumatic brain injury.

By H2HUBB Jul 22, 2026 0 Comments

In mice, the outcomes illustrated that hydrogen-rich saline treatment considerably enhanced the neurological score, increased neuronal survival, decreased the levels of serum MDA and brain ROS, increased the…

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Hydrogen Inhalation Attenuates Oxidative Stress Related Endothelial Cells Injury After Subarachnoid Hemorrhage in Rats.

By H2HUBB Jul 22, 2026 0 Comments

In a laboratory model, immunohistochemistry staining for fibrinogen showed significantly increased microthrombi counts in both cortex and hippocampus after SAH which was reduced with H₂ inhalation three times…

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Inhalation of high concentration hydrogen gas improves short-term outcomes in a rat model of asphyxia induced-cardiac arrest.

By H2HUBB Jul 22, 2026 0 Comments

In rats, during the 1 hour observation time at 48 hours post-resuscitation, seizures were observed in 50% of ACA and 20% of ACA + H₂ pre- & post-treatment…

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Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells.

By H2HUBB Jul 22, 2026 0 Comments

In a laboratory model, all of the results indicated that hydrogen decreased the levels of reactive oxygen species, 8‑iso‑prostaglandin F2α and malondialdehyde, and promoted the UVB exposure‑induced expression…

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Preconditioning with one-time hydrogen gas does not attenuate skin flap ischemia-reperfusion injury in rat models.

By H2HUBB Jul 22, 2026 0 Comments

In male Sprague Dawley rats, preconditioning with one-time inhaled hydrogen does not attenuate skin flap IR injuries in rat models. These preclinical findings add evidence about the molecular-hydrogen…

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Intermittent environmental exposure to hydrogen prevents skin photoaging through reduction of oxidative stress.

By H2HUBB Jul 22, 2026 0 Comments

In a laboratory model, detected attenuation of DNA damage in the hydrogen exposure group as indirect evidence that intermittent exposure to hydrogen gas reduced oxidative stress. The authors…

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Molecular hydrogen-mediated SIRT1 activation alleviates sepsis-associated encephalopathy by promoting mitophagy.

By H2HUBB Jul 22, 2026 0 Comments

In mice, hydrogen treatment upregulated SIRT1 expression and promoted PINK1/Parkin-mediated mitophagy, leading to reduced phosphorylation of STING, decreased levels of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α), and suppressed…

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A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine.

By H2HUBB Jul 22, 2026 0 Comments

This narrative review examined the findings of recent studies on the use of hydrogen in emergency and critical care medicine using different disease models. Hydrogen is a new…

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Effect of molecular hydrogen treatment on Sepsis-Associated encephalopathy in mice based on gut microbiota.

By H2HUBB Jul 22, 2026 0 Comments

In mice, molecular hydrogen treatment improved gut microbiota dysbiosis and partially amended metabolic disorder after SAE. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the…

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