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The researchers observed that administration of hydrogen-rich saline decreased the number of apoptotic cells, suppressed oxidative stress, and improved locomotor functions. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read ArticleIn rabbits, here, the researchers found that I/R-challenged rabbits exhibited significant spinal cord injury characterized by the decreased numbers of normal motor neurons and hind-limb motor dysfunction, which…
Read ArticleIn rats, hydrogen-rich medium attenuated the intracellular production of ROS (especially HO•), astrogliosis, and the secretion of proinflammatory cytokines in astrocytes 12 h after H₂O₂-induced injury. These preclinical…
Read ArticleIn mice, figure 1 Administration of hydrogen‐rich saline intraperitoneally from the 20th day after transplantation protects mice from cGVHD ( n = 30, P < 0.05). These preclinical…
Read ArticleIn mice, immunohistochemical staining for the oxidative stress marker, 4-hydroxy-2-nonenal and 8-hydroxydeoxyguanosine, showed that hydrogen administration suppressed oxidative stress induced by ligation in the spinal cord and the…
Read ArticleIn most diseases, the effect of hydrogen has been reported with hydrogen water or hydrogen gas, which was followed by confirmation of the effect with hydrogen-rich saline. These…
Read ArticleIn moderate and severe neonatal HI models, hydrogen gas therapy (2.9% concentration H(2)) was not associated with decreased volume of infarction or decreased concentration of MDA. These preclinical…
Read ArticleIn mice, only at the higher doses (4 and 8 mL/kg × 3), HRS conferred favorable histopathological changes in pancreatic tissues, mainly characterized by reduced cytoplasmic vacuole generation,…
Read ArticleIn Sprague-Dawley rats, hydrogen-rich saline treatment significantly attenuated the severity of l-Arg-induced AP by ameliorating the increased serum amylase activity, inhibiting neutrophil infiltration, lipid oxidation and pancreatic tissue…
Read ArticleIn Following reperfusion, segments of terminal jejunum were rapidly taken and transferred into isolated organ bath and responses to KCl were recorded, hydrogen-rich saline treatment significantly attenuated the…
Read ArticleIn rats, malondialdehyde (MDA) and myeloperoxidase (MPO) contents were obviously reduced, while superoxide dismutase (SOD) and glutathione (GSH) contents were increased after hydrogen-rich saline treatment. These preclinical findings…
Read ArticleIn rats, compared to MNU-treated rats, retinal malondialdehyde (MDA) content in MNU + hydrogen-rich saline rats significantly decreased while superoxide dismutase (SOD) activity significantly increased. These preclinical findings…
Read ArticleIn rats, hRS preserved the retinal function and mitigated the reduction of photoreceptor degeneration in MNU-treated retinas. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within…
Read ArticleIn conclusion, hydrogen molecule may be neuroprotective against ALS, possibly through abating oxidative and nitrosative stress and preserving mitochondrial function. These preclinical findings add evidence supporting molecular hydrogen's…
Read ArticleIn vitro studies also confirmed the anti-proliferative capability of the hydrogen solution and ROS generation in VSMCs induced by PDGF-BB. The authors concluded that hRSS may have a…
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