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The researchers found that saturated hydrogen saline treatment efficiently decreased the activation of ERK and JNK, while promoting the activation of p38 (P<0.05 compared with LPS), suggesting the involvement of MAPK cascades in saturated hydrogen saline-mediated liver protection. These preclinical findings add…
Read ArticleIn 262 patients, the data indicates E-HD could have substantial clinical benefits beyond conventional HD therapy, and support the rationale to conduct clinical trials of H₂ application to…
Read ArticleThe results demonstrated that 2% H₂ gas inhalation resulted in an increase in the 7-day survival rate, ALT and AST levels, RCR, and P62 and LC3B-II expression but…
Read Articlein vitro production of both TNF-alpha and IFN-gamma by ConA-stimulated spleen lymphocytes was significantly inhibited by the introduction of H(2), systemic antibiotics significantly decreased the level of H(2)…
Read ArticleIn rats, gene Ontology analysis revealed that genes for oxidoreduction-related proteins, including hydroxymethylglutaryl CoA reductase, were significantly enriched in the upregulated genes. These preclinical findings add evidence supporting…
Read ArticleIn rats, the mechanism of this phenomenon suggests that H₂ may have effectively attenuated AOC‑induced inflammatory and oxidative damage, and decreased matrix metalloproteinase activity. These preclinical findings add…
Read ArticleIn mice, cCl(4) also significantly decreased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the…
Read ArticleIn an animal model, apoptosis in cholangiocytes isolated from a rat model of liver ischemia/reperfusion injury indicated that H₂ significantly attenuates ischemia/reperfusion cholangiocyte injury in vivo. These preclinical…
Read ArticleThis publication examined molecular hydrogen using the study design reported by the authoritative source. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a…
Read ArticleIn mice, H₂ inhalation improved gut microbiota, including increasing the abundance of Lachnospiraceae and Clostridia, and decreasing the abundance of Prevotellaceae and Muribaculaceae, and also improved intestinal barrier…
Read ArticleIn mice, intraperitoneal injection of H₂ improved acute ethanol-induced liver injury in mice in a dose dependent manner, as indicated by decreasing serum ALT and AST levels, hepatic…
Read ArticleIn 6 patients, there were substantial changes in surrogate markers, such as increased CA125 and mesothelin, in the effluent in selected cases, suggesting enhanced mesothelial regeneration by H₂.…
Read ArticleHemodialysis reduced the plasma ROS scavenging activity, as shown by the augmented reference H₂O₂ and HOCl counts (Rh2o2 and Rhocl, respectively) and decreased antioxidative activity (expressed as total…
Read ArticleIn male Sprague-Dawley rats, 6d ), although there were statistically significant differences in M30 CytoDeath-positive cells (0.7 ± 0.1 and 0.9 ± 0.2 positive cells/field in the Fe-HD…
Read ArticleFollowing the introduction of hydrogen therapy, her renal function improved, evidenced by a reduction in serum creatinine levels.
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