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1,249 Articles

Modulating NLRP3 Inflammasome Activity and Enhancing Cortical Synaptic Plasticity: Nanoparticulate Hydrogen’s Role in Relief of Post-traumatic Anxiety-like Behaviors in Rats.

By H2HUBB Jul 22, 2026 0 Comments

In rats, these findings suggest that MSN-mediated hydrogen delivery is an effective strategy to address PTSD-associated affective dysfunction by orchestrating neuroimmune responses and synaptic homeostasis. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured…

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Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation.

By H2HUBB Jul 22, 2026 0 Comments

This narrative review examined hydrogen-rich saline (HS) treatment in neonatal mice has been reported to alleviate brain injury following HI, but the mechanisms involved are not known. HI…

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Molecular hydrogen attenuates methamphetamine-induced behavioral sensitization and activation of ERK-ΔFosB signaling in the mouse nucleus accumbens.

By H2HUBB Jul 22, 2026 0 Comments

In male C57BL/6 mice, due to the anti-oxidative function of molecular hydrogen, the hydrogen-rich saline injections reduced METH-induced reactive oxygen species and malondialdehyde generation in the NAc. These…

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Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model.

By H2HUBB Jul 22, 2026 0 Comments

In mice, the number of activated astrocytes with hypertrophic morphology was increased in LPS-exposed offspring, but decreased in the offspring of H₂-administered dams. These preclinical findings add evidence…

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Additive effect of clove essential oil combined with hydrogen inhalation improves psychological harm caused by lipopolysaccharide in mice.

By H2HUBB Jul 22, 2026 0 Comments

In mice, cEO administration and H₂ inhalation alone or in combination positively improved inflammation-induced anxiety, depression, and cognitive memory deficits in the mice. These preclinical findings add evidence…

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Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice.

By H2HUBB Jul 22, 2026 0 Comments

The researchers found that HRS administration significantly reduced body weight loss, jumping behavior and wet-dog shakes in mice underwent naloxone-precipitated withdrawal, and attenuated anxiety-like behaviors in the EPM…

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Hydrogen-Rich Saline Regulates Microglial Phagocytosis and Restores Behavioral Deficits Following Hypoxia-Ischemia Injury in Neonatal Mice via the Akt Pathway.

By H2HUBB Jul 22, 2026 0 Comments

In mice, consistent with the authors' previous report, 10 HI insult significantly increased brain water content (90.73 ± 1.04%) as compared with that observed in the Sham group…

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Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression.

By H2HUBB Jul 22, 2026 0 Comments

In contrast, H₂ treatment significantly suppressed the signs of I/R injury in fatty liver. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and…

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Hypothermic Machine Perfusion with Hydrogen Gas Reduces Focal Injury in Rat Livers but Fails to Restore Organ Function.

By H2HUBB Jul 22, 2026 0 Comments

In rats, liver enzyme leakage was suppressed by MP (vs control), whereas H₂ treatment did not show a combination effect. These preclinical findings add evidence about the molecular-hydrogen…

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Hydrogen-rich saline attenuates postoperative liver failure after major hepatectomy in rats.

By H2HUBB Jul 22, 2026 0 Comments

In rats, hS markedly improved the survival rate of two experimental groups after the massive hepatectomy and inhibited increases in serum levels of TBIL, DBIL, ALT and AST.…

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Hydrogen-Rich Saline Attenuates Acute Kidney Injury After Liver Transplantation via Activating p53-Mediated Autophagy.

By H2HUBB Jul 22, 2026 0 Comments

In male Sprague-Dawley rats, compared with the OLT group, HRS dramatically attenuated the histopathologic damage, restored the renal function, and decreased the oxidative stress level. These preclinical findings…

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Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications.

By H2HUBB Jul 22, 2026 0 Comments

This narrative review examined the available molecular-hydrogen literature. The delivery of molecular hydrogen (H₂) is increasingly recognized for its potential in precision immunomodulation, primarily through multiple pathways such…

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Hydrogen Flush After Cold Storage as a New End-Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury.

By H2HUBB Jul 22, 2026 0 Comments

In contrast, bile production and lactate dehydrogenase leakage therein were both significantly improved in HyFACS-HA and -PV + HA (P < 0.01), representing the superiority of the arterial…

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Combination of Cold Storage in a Heavy Water-Containing Solution and Post-Reperfusion Hydrogen Gas Treatment Reduces Ischemia-Reperfusion Injury in Rat Livers.

By H2HUBB Jul 22, 2026 0 Comments

In rats, the protective potential of the Dsol-H₂ group was superior to that of the UW group, as evidenced by lower portal venous resistance and lactate dehydrogenase leakage,…

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Hydrogen gas alleviates acute alcohol-induced liver injury by inhibiting JNK activation.

By H2HUBB Jul 22, 2026 0 Comments

In mice, H₂ treatment reduced serum TC levels in the Alcohol+H₂ group when compared with those in Alcohol group. These preclinical findings add evidence supporting molecular hydrogen's therapeutic…

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