Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
In male Sprague-Dawley rats, molecular hydrogen ameliorates MCT-induced PAH in rats by suppressing macrophage accumulation, reducing oxidative stress and modulating the STAT3/NFAT axis. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this…
Read ArticleIn participants with systemic lupus erythematosus (SLE), this case study suggests that molecular hydrogen therapy may be a promising treatment for patients with SLE-PAH, particularly due to its…
Read ArticleIn rats, mDA and 8-OHdG were significantly decreased in hydrogen-rich medium, while SOD and GSH were increased. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within…
Read ArticleIn 1 patients, iL-6 levels in the H₂ group significantly decreased in 4 weeks by 37.3 ± 62.0% compared to baseline, whereas it increased by 33.6 ± 34.4%…
Read ArticleIn male Sprague-Dawley rats, the wet/dry ratio increased significantly in the IR group (P < 0.01 compared with that in the sham group) and decreased significantly in IR…
Read ArticleIn 20 patients with rheumatoid arthritis (RA), during the first 4 weeks, 8-OHdG decreased in 17 of these patients after drinking the high H₂ water. These findings add…
Read ArticleIn a laboratory model, H₂ decreased the levels of the nitrated proteins, and suppressed chondrocyte death. The authors concluded that moreover, novel pharmacological strategies aimed at selective removal…
Read ArticleRecently, it has been demonstrated that hydrogen gas, known as a novel antioxidant, can exert therapeutic anti-inflammatory effect in many diseases. This source-grounded publication contributes evidence relevant to…
Read ArticleIn mice, based on the authors' result, H₂ enriched medium can increase super oxide dismutase (SOD) level following H₂O₂ treatment and decrease 8-hydroxy-2'-deoxyguanosine (8-OHdG) level. These preclinical findings…
Read ArticleIn an animal model, the number of senescence-associated β-galactosidase (SA-β-Gal) positive cells was reduced in BMSCs from rats treated with HRS. These preclinical findings add evidence supporting molecular…
Read ArticleIn Methotrexate (MTX) remains a cornerstone of RA treatment, offering significant therapeutic benefits, this is the first case report to highlight severe MTX-induced myelosuppression in an RA patient…
Read ArticleIn rats, treatment with HW abated oxidative stress and suppressed IL-6 and TNF-α mRNA expressions in femur of ovariectomized rats; treatment with HW increased femur endothelial NOS activity…
Read ArticleIn Sprague-Dawley rats, treatment with HW alleviated HLS-induced reduction of bone mineral density, ultimate load, stiffness, and energy in femur and lumbar vertebra. These preclinical findings add evidence…
Read ArticleIn mice, H₂ treatment significantly attenuated ROS production in AβO-stimulated primary mouse astrocytes, showing a 1.2-fold reduction compared with vehicle ( p < 0.05; Figure 2 A). These…
Read ArticleIn a laboratory model, hS treatment mitigated isoflurane-induced ROS accumulation, opening of mitochondrial permeability transition pores, reduction in mitochondrial membrane potential, and reduction in cellular ATP levels. The…
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