Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease.

This animal study examined Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. The abstract describes Mouse model. The abstract reports: The concentration-dependency of H(2) showed that H(2) as low as 0.08 ppm had almost the same effect as saturated H(2) water (1.5 ppm). This is an automated editorial draft based on the abstract and requires source review before publication.

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Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases.

This narrative review examined Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases. The abstract describes Published literature review. The abstract reports: While preclinical studies demonstrate promising results, clinical trials conducted thus far have yielded mixed outcomes, with some trials reporting limited or no therapeutic benefit. This is an automated editorial draft based on the abstract and requires source review before publication.

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Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice.

This animal study examined Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice. The abstract describes Mouse model. The abstract reports: The protective effect of H water was still observed in the vagotomized mice in substantia nigra, suggesting that stimulation of vagal afferent nerves is…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Electrochemically reduced water exerts superior reactive oxygen species scavenging activity in HT1080 cells than the equivalent level of hydrogen-dissolved water

This in vitro or cellular study examined Electrochemically reduced water exerts superior reactive oxygen species scavenging activity in HT1080 cells than the equivalent level of hydrogen-dissolved water. The abstract describes HT1080 cell model. The abstract reports: ERW has reactive oxygen species (ROS)-scavenging activity and recent studies demonstrated that hydrogen-dissolved water exhibits ROS-scavenging activity. This is an automated editorial draft based on the abstract and requires source review before publication.

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Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis.

This in vitro or cellular study examined Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis. The abstract describes Cell culture / in vitro model. This is an automated editorial draft based on the abstract and requires source review before publication.

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Molecular hydrogen suppresses free-radical-induced cell death by mitigating fatty acid peroxidation and mitochondrial dysfunction.

This in vitro or cellular study examined Molecular hydrogen suppresses free-radical-induced cell death by mitigating fatty acid peroxidation and mitochondrial dysfunction. The abstract describes Cell culture / in vitro model. The abstract reports: As a result, H protected the cultured cells against the cytotoxic effects induced by -butyl hydroperoxide; H suppressed cellular fatty acid peroxidation and cell…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-rich medium protects mouse embryonic fibroblasts from oxidative stress by activating LKB1-AMPK-FoxO1 signal pathway.

This animal study examined Hydrogen-rich medium protects mouse embryonic fibroblasts from oxidative stress by activating LKB1-AMPK-FoxO1 signal pathway. The abstract describes Mouse model. The abstract reports: These results suggest that the LKB1-AMPK-FoxO1 signaling pathway is a critical mediator of the antioxidant properties of H, further supporting the idea that H…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen gas alleviates oxygen toxicity by reducing hydroxyl radical levels in PC12 cells.

This in vitro or cellular study examined Hydrogen gas alleviates oxygen toxicity by reducing hydroxyl radical levels in PC12 cells. The abstract describes PC12 cell model. The abstract reports: The data showed that H2 promoted the cell viability and inhibited the damage in the cell and mitochondria membrane, reduced the levels of lipid…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-rich jelly attenuates adipose tissue inflammation and metabolic dysfunction in high-fat/high-sucrose diet-fed SAMP8 mice.

This in vitro or cellular study examined Hydrogen-rich jelly attenuates adipose tissue inflammation and metabolic dysfunction in high-fat/high-sucrose diet-fed SAMP8 mice. The abstract describes Cell culture / in vitro model. The abstract reports: These findings suggest that molecular hydrogen attenuates HFHSD-induced metabolic disturbances primarily through suppression of adipose inflammation. This is an automated editorial draft based on the abstract and requires source review before publication.

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Molecular Hydrogen Promotes Adipose-derived Stem Cell Myogenic Differentiation Regulation of Mitochondria.

This in vitro or cellular study examined Molecular Hydrogen Promotes Adipose-derived Stem Cell Myogenic Differentiation Regulation of Mitochondria. The abstract describes Stem-cell model. The abstract reports: This study reveals the application potential of H in skeletal muscle diseases or other pathologies related to mitochondrial dysfunction. This is an automated editorial draft based on the abstract and requires source review before publication.

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The effect of hydrogen gas on the oxidative stress response in adipose tissue.

This uncontrolled human study examined The effect of hydrogen gas on the oxidative stress response in adipose tissue. The abstract describes Human participants. The abstract reports: The immunostaining results showed that HO-1 and Nrf2 expression levels were significantly decreased in the hydrogenated group, whereas SOD expression levels increased, but did…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women.

This registered clinical trial examined Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women. The abstract describes Planned or registered research population; reported duration 4 week. The abstract reports: It appears that orally administered H as a blend of hydrogen-generating minerals might be a beneficial agent in the management of body composition and…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen is neuroprotective against surgically induced brain injury.

This uncontrolled human study examined Hydrogen is neuroprotective against surgically induced brain injury. The abstract describes Human participants. The abstract reports: SBI resulted in localized brain edema (p = < 0.001). This is an automated editorial draft based on the abstract and requires source review before publication.

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Molecular hydrogen modulates brain glutamate/GABA-glutamine cycle in overweight humans.

This uncontrolled human study examined Molecular hydrogen modulates brain glutamate/GABA-glutamine cycle in overweight humans. The abstract describes Human participants. The abstract reports: We showed a possible hydrogen-driven upregulation of neurotransmitters involved in appetite stimulation leading to hunger suppression and weight loss. Further studies analyzing appetite-controlling metabolic…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Molecular Hydrogen Therapy Enhances Immune Markers in Treg, Plasma, Tr1 Cells, and KLRG1 Expression on Tc Cells: A Case of Acute SDH With Midline Shift and Uncal Herniation Post-decompressive Craniectomy

This uncontrolled human study examined Molecular Hydrogen Therapy Enhances Immune Markers in Treg, Plasma, Tr1 Cells, and KLRG1 Expression on Tc Cells: A Case of Acute SDH With Midline Shift and Uncal Herniation Post-decompressive Craniectomy. The abstract describes Human participants. The abstract reports: This case suggests that molecular hydrogen therapy may be a helpful adjunct treatment for SDH with midline shift. Conventional therapies, including craniectomy, hyperbaric oxygen,…. This is an automated editorial draft based on the abstract and requires source review before publication.

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