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In rats, using this system, the concentration of H₂ in unit volume can be greatly improved under normal temperature and pressure conditions. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read ArticleIn male Wistar rats, the apoptosis rate was significantly decreased in the hydrogen-rich water group, as well. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within…
Read ArticleIn rats, nFkB-p65 and c-Fos in the nucleus were unexpectedly unchanged by IRI regardless of H₂ treatment, indicating the absence of inflammation in this model. These preclinical findings…
Read ArticleIn an animal model, the NT, H₂, and H₂ -TH groups showed a significant reduction in HR at 0 h (end of insult), whereas the TH group showed…
Read ArticleIn rats, hydrogen-containing saline (HCS) treatment was observed to improve interstitial fibrosis and cardiac function and to decrease the level of ROS, the oxidative‑stress marker MDA and expression…
Read ArticleIn mice, although treatment of diabetic mice with hydrogen water did not significantly affect blood glucose level, it significantly attenuated cardiac hypertrophy and reduced expression of atrial natriuretic…
Read ArticleIn an animal model, although the W/D ratio in the CPB group significantly increased as compared with that in the SHAM group, such an increase was also suppressed…
Read ArticleIn rats, it also decreased neutrophil infiltration, 3-nitrotyrosine level, expression of intercellular adhesion molecule 1(ICAM-1) and myeloperoxidase (MPO) activity in the area at risk zones (AAR) of rat…
Read ArticleIn rats, finally, as a pivotal transcription factor in reactive oxygen species (ROS)-apoptosis signaling pathway, the expression and phosphorylation of p53 were significantly reduced by H₂ treatment in…
Read ArticleIn mice, nO inhalation plus H₂ reduced the infarct size/AAR, with significant interaction between the two, reducing ROS and neutrophil infiltration, and improved the cardiac function to normal…
Read ArticleThe researchers found that both 0.3 mmol/L and 0.6 mmol/L (i.e., saturated) H₂-rich media improved cell viability and cellular apoptosis in LPS-activated HUVECs and that 0.6mmol/L (i.e., saturated)…
Read ArticleIn Sprague-Dawley rats, the purpose of the present study was to determine whether using hydrogen-rich medium (HRM) to increase hydrogen levels in endothelial cells (ECs) protects ECs from…
Read ArticleIn Sprague Dawley rats, hRS treatment significantly increased the viability of myocardial cells, reduced the rate of myocardial cellular apoptosis and the release of MDA and LDH compared…
Read ArticleIn Sprague-Dawley rats, compared with the sham-operated rats, the p-STAT3 expression levels in the AAC-treated rat hearts were significantly increased, which were prevented with treatment of hydrogen-rich saline…
Read ArticleIn an animal model, h(2) treatment decreased serum ox-LDL level and apoptosis in plaques with concomitant inhibition of endoplasmic reticulum stress (ERS) and reduction of reactive oxygen species…
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