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In Sprague-Dawley rats, the antibiotics suppressed the regeneration-promoting effect of lactulose by reducing hydrogen production, whereas supplementing hydrogen by hydrogen-rich saline would get a similar regeneration-promoting effect as lactulose administration. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the…
Read ArticleIn male Sprague Dawley rats, hydrogen-rich saline can attenuate myocardial reperfusion injury through inhibiting cardiomyocyte autophagy. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the…
Read ArticleIn male Sprague-Dawley rats, bax was significantly decreased in the SP group. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways…
Read ArticleIn rats, the value of both Hcy/HHcy and Cys/Cyss were significantly decreased with the change of Micro-CT scan result of femoral neck in OVX group (both the trabecular…
Read ArticleIn rats, western blot analysis showed decreased NLRP3, ASC, caspase-1, MMP-2/9, TLR4 and Bax protein levels after hydrogen-rich saline treatment, while Bcl-2 expression increased after hydrogen-rich saline treatment.…
Read ArticleIn rats, the use of hydrogen-rich saline significantly improved the survival rate (p < 0.05), and glycocalyx degeneration was significantly suppressed (p < 0.001), indicating the protective effect…
Read ArticleIn rats, the VSD + H₂ group demonstrated superior efficacy in reducing serum inflammatory markers compared to the VSD group (Figure 1F ), with significantly lower malondialdehyde (MDA)…
Read ArticleIn rats, compared with the controls, the rats in the HRW group showed markedly decreased oxidative stress-related index CYBB (P < 0.01), increased eNOS level (P < 0.01),…
Read ArticleIn rats, hW intake can potentially reduce oxidative stress and prevent renal injury in neonates with high oxygen loading. These preclinical findings add evidence supporting molecular hydrogen's therapeutic…
Read ArticleIn male Sprague-Dawley rats, molecular hydrogen-alleviated damage decreased the testicular apoptosis rate and apoptosis protein level, increased sperm motility, increased serum testosterone levels, and improved antioxidative capacity. These…
Read ArticleIn conclusion, this study revealed the plausible use of HRW as a new therapy for the allodynia and physical and mental impairments linked with CIS and its possible…
Read ArticleIn an animal model, HRW replacement significantly decreased Nrf2 expression in the prefrontal cortex and hippocampal CA2 region at 14 and 30 DPI, respectively. These preclinical findings add…
Read ArticleThe results indicated that the antiallodynic actions of the co-administration of CoPP plus HRW are more rapid and higher than those given by each of them when independently…
Read ArticleIn mice, the injection of hydrogen-rich water into the Zusanli (ST36) acupoint effectively inhibited the hyperplasia of 4T1 BC cells and enhanced their apoptosis, potentially exerting a therapeutic…
Read ArticleIn mice, sNL induced alterations in the levels of several bile acid metabolites, particularly the secondary bile acids, such as HDCA and DCA, which were significantly decreased but…
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