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In an animal model, hydrogen gas treatment significantly attenuated HI-induced apoptosis in both cortical neurons and white matter oligodendrocytes, thereby preserving their cell densities to levels comparable to uninjured controls. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the…
Read ArticleIn mice, hydrogen gas suppressed the increase in eye-scratching behavior. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in…
Read ArticleIn mice, the Si–based agent generates molecular hydrogen in the intestine and has previously been shown to alleviate symptoms in various oxidative stress–related disease models, including ulcerative colitis,…
Read ArticleIn bone marrow, the reduction in CD11b+Ly-6G+ neutrophils observed in AAD mice was significantly attenuated by H₂ inhalation. In the aortic wall, H₂ reduced MMP-9 and CXCL1 expression,…
Read ArticleIn vivo, QCH-NMs maintained 100% survival, restored epithelial thickness to 59.16 ± 2.97 μm versus 31.56 ± 2.48 μm in the model group, upregulated Ki67 (26.53%) and Nrf2…
Read ArticleIn mice, 67% hydrogen inhalation markedly mitigated SAE-induced cognitive dysfunction by restraining mTOR overactivation to promote oligodendrocyte maturation and myelin reconstruction; rapamycin treatment exerted synergistic neuroprotective efficacy. These…
Read ArticleIn rats, instead, HRW specifically attenuated the local senescent microenvironment, with a reduction in both SA-β-gal activity and the expression of p16, p21 within the fracture gap. These…
Read ArticleIn rats, histological analysis revealed a marked reduction of interstitial congestion, edema, inflammation, and hemorrhage in renal tissue harvested 24 h after HRSS treatment compared to saline administration.…
Read ArticleIn rats, the lung injury score determined by histopathology, the cell apoptotic index, and the caspase-3 protein expression in lung grafts were decreased after hydrogen treatment, and the…
Read ArticleIn rats, hydrogen improved PaO(2)/FIO(2) and PVO(2)/FIO(2) from the arterial and pulmonary venous blood in recipients and decreased the lung injury score in grafts from brain-dead donors. These…
Read ArticleIn the present study, the researchers found that inhalation of H₂ (2%) or hyperoxia (98%) alone improved the 14-day survival rate of septic mice with moderate cecal ligation…
Read ArticleIn an animal model, here, the researchers found that TBI-challenged rats showed significant brain injuries characterized by the increase of BBB permeability, brain edema and lesion volume as…
Read ArticleIn rabbits, after 240 min of reperfusion, intraperitoneal administration of HRS increased PaO2/FiO2 ratio and superoxide dismutase activities, and decreased malondialdehyde contents, proinflammatory cytokines expression, and myeloperoxidase activities,…
Read ArticleIn rats, the intracellular surfactant pool, tissue adenosine triphosphate (ATP) levels and heat shock protein 70 (HSP70) expression increased in the hydrogen-treated grafts. These preclinical findings add evidence…
Read ArticleIn an animal model, hydrogen-rich water intake inhibited an increase in serum ROS level and lowered expression of 8-hydroxydeoxyguanosine and nitrotyrosine in the periodontal tissue at 4 weeks.…
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