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In BALB/c mice, forty percent of aGVHD mice with physiologic saline treatment survived to the 18 th day after BMT, and 90% of the mice with hydrogen-rich saline had survived ( Figure 1 ).This result suggests that hydrogen-rich saline can protect mice…
Read ArticleIn male Sprague-Dawley rats, tumor necrosis factor-alpha (TNF-α) levels, malondialdehyde (MDA) concentrations, nuclear factor kappa B (NF-κB) p65 expression, and apoptosis index (AI) in I+HS group were significantly…
Read ArticleIn Sprague-Dawley rats, compared with group C and group S, HRS and EDHB injection significantly increased the number of autophagosomes and autolysosomes in the spinal cord at 14…
Read ArticleIn guinea pigs, the frequencies of sneezing and scratching, as well as the levels of IgE, IL-4, and IL-13, in the serum were higher in the AR group…
Read ArticleIn mice, kEY FINDING: The leakage and non-perfusion areas of retinal blood vessels were not alleviated in the HRS treatment group. These preclinical findings add evidence supporting molecular…
Read ArticleIn male Sprague-Dawley rats, the histopathology results also showed that H₂-rich saline ameliorated DCS injuries. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes…
Read ArticleIn conclusion, hydrogen-rich saline (10 ml/kg) might reverse remifentanil-induced hyperalgesia, through regulating NR2B-containing NMDAR trafficking to control MnSOD nitration and enhance MnSOD activity. These preclinical findings add evidence…
Read ArticleThe results of the present study demonstrate that, after experimental spinal cord injury in rats, hydrogen-rich water treatment significantly decreased inflammation as evidenced by decreased IL-6 and TNF-α…
Read ArticleThe researchers observed that administration of hydrogen-rich saline decreased the number of apoptotic cells, suppressed oxidative stress, and improved locomotor functions. These preclinical findings add evidence supporting molecular…
Read ArticleIn rabbits, here, the researchers found that I/R-challenged rabbits exhibited significant spinal cord injury characterized by the decreased numbers of normal motor neurons and hind-limb motor dysfunction, which…
Read ArticleIn rats, hydrogen-rich medium attenuated the intracellular production of ROS (especially HO•), astrogliosis, and the secretion of proinflammatory cytokines in astrocytes 12 h after H₂O₂-induced injury. These preclinical…
Read ArticleIn rabbits, bolus administration of HS (10 mL) transiently increased the current to only 1/30th and 1/27th of the plateau current with 1.2% H₂ gas inhalation in two…
Read ArticleIn mice, figure 1 Administration of hydrogen‐rich saline intraperitoneally from the 20th day after transplantation protects mice from cGVHD ( n = 30, P < 0.05). These preclinical…
Read ArticleIn mice, immunohistochemical staining for the oxidative stress marker, 4-hydroxy-2-nonenal and 8-hydroxydeoxyguanosine, showed that hydrogen administration suppressed oxidative stress induced by ligation in the spinal cord and the…
Read ArticleIn most diseases, the effect of hydrogen has been reported with hydrogen water or hydrogen gas, which was followed by confirmation of the effect with hydrogen-rich saline. These…
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