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In the H₂ treatment group (group H), these proteins were significantly decreased. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read ArticleIn an animal model, nissl staining demonstrated a significant decrease in the number of nissl-stained dark neurons (N-DNs) in HI group compared to TBI group at 2 h…
Read ArticleIn an animal model, the inhalation of 42% H₂ for one hour per day for 48 h significantly reduced brain edema, decreased the extravasation of sodium fluorescein, and…
Read ArticleIn rats, effect of hydrogen on S100- β and NSE levels The levels of S100-β and NSE have similar trends, these increased in the I/R group compared with…
Read ArticleIn rats, hydrogen-rich water administration significantly increased 7-d survival rates, reduced neurologic deficits, and lowered intracellular oxidative stress levels. These preclinical findings add evidence supporting molecular hydrogen's therapeutic…
Read ArticleIn Sprague-Dawley rats, bcl-2 was significantly increased while Bax and cleaved caspase-3 was decreased by HS treatment. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within…
Read ArticleIn contrast, the upregulated level of MDA, caspase-12/3 and brain edema was attenuated and the brain injury was substantially alleviated in the hydrogen treated rabbits, but the improvement…
Read ArticleIn mice, hydrogen inhalation significantly reduced infarct volume, attenuated brain edema and improved neurobehavioral deficit in MCAO mice. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential…
Read ArticleIn rats, at 24 hours, 48 hours, 1 week and 2 weeks after injury showed that hydrogen-rich saline markedly reduced cell death, inflammatory cell infiltration, serum malondialdehyde content,…
Read ArticleIn rats, these results demonstrated that H₂ significantly reduced the number of apoptotic cells, and the protein expression of p38 MAPK and caspase‑3, compared with the IR group.…
Read ArticleIn Sprague-Dawley rats, hydrogen administration reduced the expression of 8-OHdG in the brain, but did not attenuate brain water content or improve functional outcome, regardless of administration route.…
Read ArticleIn male Sprague-Dawley rats, hydrogen treatment significantly reduced the level of oxidative stress, neuroinflammation, neuronal damage, and apoptosis-related genes. These preclinical findings add evidence supporting molecular hydrogen's therapeutic…
Read ArticleThe results demonstrated that TBI-challenged rats exhibited significant brain injuries that were characterized by decreased survival rate and increased BBB permeability, brain edema, and neurological dysfunction, while HRW…
Read ArticleIn mice, the hydrogen inhalation reduced these effects acutely (24 h); however it exhibited only a tendency to improvement in the delayed study (72 h). These preclinical findings…
Read ArticleIn rats, the beneficial effects of hydrogen-rich saline were associated with decreased levels of oxidative products, as well as the increased levels of antioxidant enzymes. These preclinical findings…
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