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In rats, hRS and HBO could all decrease the release of immflammatory cytokines in lung tissue, reduce accumulation of oxidative products and alleviate apoptosis of pulmoanry cells, and could produce good therapeutic effects on ALI induced by LPS. These preclinical findings add…
Read ArticleIn male Sprague-Dawley rats, h(2)-rich saline treatment improved the cognitive deficits and reduced the degree of necrosis, apoptosis, and cell autophagy in rats. These preclinical findings add evidence…
Read ArticleIn mice, spinal cord neurons were preserved by hydrogen administration after mechanical injury in a dose-dependent manner. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within…
Read ArticleIn mice, the present study was designed to investigate whether hydrogen-rich saline (HS) attenuates HIBD in neonatal mice and whether the observed protection is associated with reduced endoplasmic…
Read ArticleThe researchers found that the beneficial effects of H₂ on brain injury in septic mice were linked to the decreased levels of inflammatory cytokines and oxidative products and…
Read ArticleThe researchers found that the expression of LC3 was increased after OGD/R which can be further enhanced by H₂ and RAP treatment, but treatment with 3-MA was opposite.…
Read ArticleIn rats, after the HRW treatment, the oxidative stress status in the liver was improved, SOD activities and MDA levels were restored, CAT activities and GSH levels were…
Read ArticleIn C57BL/6 mice, western blot analysis showed that coadministration of 1.3% hydrogen gas significantly (P < 0.001) reduced the level of neuronal apoptosis to approximately 40% compared with…
Read ArticleIn rats, hydrogen-rich saline plays a protective role in ANP-induced AHI through inhibiting inflammation and apoptosis, involving JNK and p38 MAPK-dependent reactive oxygen species. These preclinical findings add…
Read ArticleIn mice, the removal of mtROS by H₂ reduced the generation of oxidized mitochondrial DNA and consequently decreased its binding to NLRP3, thereby inhibiting the NLRP3 inflammasome activation.…
Read ArticleIn an animal model, compared with the MC group, both HRW and LAC treatments attenuated the reduction of villus height in small intestines (duodenum, jejunum, and ileum) caused…
Read ArticleIn rats, lactulose increased breath hydrogen concentrations in 86% of healthy participants and 59% of PD patients. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within…
Read ArticleIn rats, the data showed that the spatial recognition memory and fear memory of the rats treated with sevoflurane decreased compared with the control, and the cognitive function…
Read ArticleIn rats, both inhaling 2% hydrogen and ischemic postconditioning treatment reduced the ischemic size and serum troponin I level in rats with I/R injury, and inhaling hydrogen showed…
Read ArticleIn rats, the eAE-hydrogen-rich saline increased significantly left ventricular systolic pressure, reduced left ventricular end-diastolic pressure, and potentiated + dp/dtmax, -dp/dtmax, heart coefficient and pH after MI injury.…
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