Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest Independently of Targeted Temperature Management
This animal study examined Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest Independently of Targeted Temperature Management. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation. The abstract reports: H2 inhalation was beneficial when begun after ROSC, even when delivered in the absence of hyperoxia. Combined TTM and H2 inhalation was more effective…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffect of hydrogen gas on the survival rate of mice following global cerebral ischemia.
This animal study examined Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia. The abstract describes Mouse model; sample size 12. The abstract reports: Global cerebral ischemia and reperfusion (I/R) often result in high mortality. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats.
This animal study examined Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats. The abstract describes Rat model; reported duration 2 hrs. The abstract reports: Hydrogen gas could exert its neuroprotective effect against early brain injury after subarachnoid hemorrhage by its antioxidative activity. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtection of the endothelium and endothelial glycocalyx by hydrogen against ischaemia-reperfusion injury in a porcine model of cardiac arrest.
This animal study examined Protection of the endothelium and endothelial glycocalyx by hydrogen against ischaemia-reperfusion injury in a porcine model of cardiac arrest. The abstract describes Porcine model; hydrogen delivered as hydrogen inhalation. The abstract reports: In pigs, hydrogen gas inhalation during CPR and post-resuscitation care was associated with less pronounced metabolic acidosis compared to controls. However, we could not…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAssociation between hydrogen gas inhalation and cardiac output in an asphyxiated piglet model
This animal study examined Association between hydrogen gas inhalation and cardiac output in an asphyxiated piglet model. The abstract describes Porcine model; hydrogen delivered as hydrogen inhalation. The abstract reports: The HI group (n = 10) showed a transient increase in SV and CO followed by a decline. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-Rich Saline—A Novel Neuroprotective Agent in a Mouse Model of Experimental Cerebral Ischemia via the ROS-NLRP3 Inflammasome Signaling Pathway In Vivo and In Vitro
Our previous research revealed that inflammation plays an important role in the pathophysiology of cerebral ischemia. The function of the NOD-like receptor protein 3 (NLRP3) inflammasome is to activate the inflammatory process. Recent findings suggest that reactive oxygen species (ROS) are essential secondary messengers that activate the NLRP3 inflammasome.
Read MoreHydrogen-rich saline alleviates early brain injury through inhibition of necroptosis and neuroinflammation via the ROS/HO-1 signaling pathway after traumatic brain injury.
This animal study examined Hydrogen-rich saline alleviates early brain injury through inhibition of necroptosis and neuroinflammation via the ROS/HO-1 signaling pathway after traumatic brain injury. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. The abstract reports: Hydrogen, which is a slight and specific cytotoxic oxygen radical scavenger, has been demonstrated to ameliorate early brain injury (EBI) through reactive oxygen species…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Inhalation Attenuates Oxidative Stress Related Endothelial Cells Injury After Subarachnoid Hemorrhage in Rats.
Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease with poor clinical outcome. Nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome serves a key role in inflammatory response, which may lead to endothelial cell injury and blood-brain barrier (BBB) disruption. Hydrogen (H) is considered a neuroprotective antioxidant.
Read MoreHydrogen-rich saline alleviates early brain injury through regulating of ER stress and autophagy after experimental subarachnoid hemorrhage
This animal study examined Hydrogen-rich saline alleviates early brain injury through regulating of ER stress and autophagy after experimental subarachnoid hemorrhage. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. The abstract reports: The results of this study demonstrate that hydrogen-rich saline improves neurological outcomes in mice and reduces neuronal death by protecting against neural autophagy and…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreLongitudinal multiparametric MRI study of hydrogen-enriched water with minocycline combination therapy in experimental ischemic stroke in rats.
This animal study examined Longitudinal multiparametric MRI study of hydrogen-enriched water with minocycline combination therapy in experimental ischemic stroke in rats. The abstract describes Rat model. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreInhalation of high concentration hydrogen gas improves short-term outcomes in a rat model of asphyxia induced-cardiac arrest
This animal study examined Inhalation of high concentration hydrogen gas improves short-term outcomes in a rat model of asphyxia induced-cardiac arrest. The abstract describes Rat model; reported duration 1 hour. The abstract reports: Findings of this preclinical study suggest that water electrolysis-derived 60% hydrogen gas may improve short-term outcomes in cardiogenic global brain hypoxia-ischemia. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreSustained‐Release Photothermal Microneedles for Postoperative Incisional Analgesia and Wound Healing via Hydrogen Therapy
This animal study examined Sustained‐Release Photothermal Microneedles for Postoperative Incisional Analgesia and Wound Healing via Hydrogen Therapy. The abstract describes Animal model. The abstract reports: In vitro results showed that PDA@ZIF-8@AB nanoparticles can release H continuously for up to 5 days in an acidic microenvironment, while the photothermal properties…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreBeneficial effects of hydrogen-rich saline on early burn-wound progression in rats.
This animal study examined Beneficial effects of hydrogen-rich saline on early burn-wound progression in rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: Hydrogen can attenuate early wound progression following deep burn injury. The beneficial effect of hydrogen was mediated by attenuating oxidative stress, which inhibited apoptosis…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAtomic hydrogen surrounded by water molecules, H(H2O)m, modulates basal and UV-induced gene expressions in human skin in vivo.
This animal study examined Atomic hydrogen surrounded by water molecules, H(H2O)m, modulates basal and UV-induced gene expressions in human skin in vivo. The abstract describes Animal model. The abstract reports: We found that H(H2O)m prevented UV-induced ROS generation and inhibited UV-induced MMP-1, COX-2 and IL-6 expressions, and UV-induced JNK and c-Jun phosphorylation in HaCaT…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway.
This animal study examined Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: The results indicate that hydrogen-rich saline could ameliorate ischemia/reperfusion injury and improve flap survival rate by inhibiting the apoptosis factor and, at the same…. This is an automated editorial draft based on the abstract and requires source review before publication.
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