Postconditioning with inhaled hydrogen attenuates skin ischemia/reperfusion injury through the RIP-MLKL-PGAM5/Drp1 necrotic pathway.
This animal study examined Postconditioning with inhaled hydrogen attenuates skin ischemia/reperfusion injury through the RIP-MLKL-PGAM5/Drp1 necrotic pathway. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation. The abstract reports: In the SH and HCH groups, the necrotic factors measured here showed similar expression levels, which were significantly lower than the levels in the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen-mediated SIRT1 activation alleviates sepsis-associated encephalopathy by promoting mitophagy
This animal study examined Molecular hydrogen-mediated SIRT1 activation alleviates sepsis-associated encephalopathy by promoting mitophagy. The abstract describes Mouse model. The abstract reports: This study demonstrates that inhalation of 2% H2 exerts significant protective effects against SAE, in which SIRT1 plays a pivotal role by modulating PINK1-dependent…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway.
This in vitro or cellular study examined Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway. The abstract describes Cell culture / in vitro model; hydrogen delivered as hydrogen inhalation. The abstract reports: Sepsis-associated encephalopathy (SAE) is the cognitive impairment resulting from sepsis and is associated with increased morbidity and mortality. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAug 2019(mitochondrial dysfunction ,sepsis, autophagy)Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy-mediated NLRP3 inflammasome inactivation in sepsis
This animal study examined Aug 2019(mitochondrial dysfunction ,sepsis, autophagy)Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy-mediated NLRP3 inflammasome inactivation in sepsis. The abstract describes Mouse model. The abstract reports: The results demonstrated that LPS and ATP led to NLRP3 inflammasome pathway activation, excessive cytokine release, mitochondrial dysfunction and the activation of autophagy. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas presents a promising therapeutic strategy for sepsis.
This uncontrolled human study examined Hydrogen gas presents a promising therapeutic strategy for sepsis. The abstract describes Human participants. The abstract reports: Recently, some studies have found that molecular hydrogen is a new therapeutic gas. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-Rich Saline Regulates Intestinal Barrier Dysfunction, Dysbiosis, and Bacterial Translocation in a Murine Model of Sepsis.
This animal study examined Hydrogen-Rich Saline Regulates Intestinal Barrier Dysfunction, Dysbiosis, and Bacterial Translocation in a Murine Model of Sepsis. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline; reported duration 7 days. The abstract reports: In the results, the 7-day survival rate was significantly improved in the H2 group versus the control group (69% vs. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Gas Protects Against Intestinal Injury in Wild Type But Not NRF2 Knockout Mice With Severe Sepsis by Regulating HO-1 and HMGB1 Release.
This animal study examined Hydrogen Gas Protects Against Intestinal Injury in Wild Type But Not NRF2 Knockout Mice With Severe Sepsis by Regulating HO-1 and HMGB1 Release. The abstract describes Mouse model. The abstract reports: The results showed that therapy with 2% H2 increased the survival rate, alleviated the injuries caused by oxidative stress and inflammation, reduced HMGB1 levels…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release.
This uncontrolled human study examined Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. The abstract describes Human participants. The abstract reports: Recently, it has been suggested that molecular hydrogen (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radicals (*OH, the most cytotoxic reactive…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas therapy: A promising approach for sepsis management post-burn injury by modulating inflammation, oxidative stress, and wound healing.
This uncontrolled human study examined Hydrogen gas therapy: A promising approach for sepsis management post-burn injury by modulating inflammation, oxidative stress, and wound healing. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: Wound healing was monitored, with wound contraction rates recorded and histological assessments conducted using hematoxylin and eosin and Masson's trichrome staining to evaluate tissue…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen regulates mitochondrial quality to protect glial cells and alleviates sepsis-associated encephalopathy by Nrf2/YY1 complex promoting HO-1 expression.
Sepsis-associated encephalopathy (SAE) is a complication of the central nervous system in patients with sepsis. Currently, no effective treatment for sepsis is available. Hydrogen plays a protective role in different diseases; however, the detailed mechanism of hydrogen-treated disease remains unclear.
Read MoreEffect of molecular hydrogen treatment on Sepsis-Associated encephalopathy in mice based on gut microbiota.
This uncontrolled human study examined Effect of molecular hydrogen treatment on Sepsis-Associated encephalopathy in mice based on gut microbiota. The abstract describes Human participants; hydrogen delivered as hydrogen water and hydrogen inhalation. The abstract reports: Molecular hydrogen treatment promotes functional outcomes after SAE in mice, which may be attributable to increasing beneficial bacteria, repressing harmful bacteria, and metabolic disorder,…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreiTRAQ-Based Quantitative Proteomic Analysis of Intestines in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment.
This uncontrolled human study examined iTRAQ-Based Quantitative Proteomic Analysis of Intestines in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment. The abstract describes Human participants. The abstract reports: A total of 199 differential proteins were related with H in the intestinal protection of sepsis. H-related differential proteins were notably enriched in the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHigh-concentration hydrogen inhalation mitigates sepsis-associated encephalopathy in mice by improving mitochondrial dynamics.
This animal study examined High-concentration hydrogen inhalation mitigates sepsis-associated encephalopathy in mice by improving mitochondrial dynamics. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation. The abstract reports: Inhalation of high concentration (67%) of H in septic mice improved the survival rate and reduced neuronal injury. Its mechanism might be mediated by…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MorePharmacokinetics of hydrogen administered intraperitoneally as hydrogen-rich saline and its effect on ischemic neuronal cell death in the brain in gerbils.
This in vitro or cellular study examined Pharmacokinetics of hydrogen administered intraperitoneally as hydrogen-rich saline and its effect on ischemic neuronal cell death in the brain in gerbils. The abstract describes Cell culture / in vitro model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: Intraperitoneal administration of H2-rich saline resulted in large increases in H2 concentration in the IVC ranging from 0.00183 mg/L (0.114%) to 0.00725 mg/L (0.453%). This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen‐rich and hyperoxygenate saline inhibits lipopolysaccharide‐induced lung injury through mediating NF‐κB/NLRP3 signaling pathway in C57BL/6 mice
This animal study examined Hydrogen‐rich and hyperoxygenate saline inhibits lipopolysaccharide‐induced lung injury through mediating NF‐κB/NLRP3 signaling pathway in C57BL/6 mice. The abstract describes Mouse model; hydrogen delivered as injected or infused hydrogen. The abstract reports: Hydrogen plays a more important role in the inflammatory and anti-apoptosis mechanisms, while oxygen improves hypoxia of the body, and thus, its molecular mechanism…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreBlog Categories
Recent Posts
October 21, 2020
November 16, 2020
October 02, 2017