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In rats, compared with PHN group,the rats in the PHN-H₂ group and PHN-H₂-Rap group showed increased PWT,decreased levels of TNF-α,IL-1β and IL-6,further up-regulated expressions of LC3 and beclin 1 as wel as P62 expression. These results are preclinical and suggest molecular hydrogen's…
Read ArticleIn rats, nSS scores in TBI and TBI+HW groups showed a decreased tendency with time prolongation after TBI. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential…
Read ArticleIn hypertensive mice, filtered water reduced blood pressure and was associated with antioxidant and anti-inflammatory changes. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the…
Read ArticleIn 2 patients, the induction of hydrogen gas production and the reduction in peripheral blood IL-1β mRNA after the test meal were not significant between days 1 (without…
Read ArticleIn rats, the data showed that the spatial recognition memory and fear memory of the rats treated with sevoflurane decreased compared with the control, and the cognitive function…
Read ArticleIn rats, hydrogen saline significantly reduced the infarct volume and edema and improved the neurological function, when it was administered at 0, 3 and 6 h after reperfusion.…
Read ArticleIn mice, compared with female mice, H₂ administration post-ICH exhibited fewer neuroprotective effects, including decreased sucrose consumption and time spent sniffing a novel mouse, increased immobility time, downregulated…
Read ArticleThe results demonstrated that TBI-challenged rats exhibited significant brain injuries that were characterized by decreased survival rate and increased BBB permeability, brain edema, and neurological dysfunction, while HRW…
Read ArticleThe researchers found that the beneficial effects of hydrogen-rich saline treatment were associated with decreased levels of oxidative products (8-iso-prostaglandin F2α and malondialdehyde) and inflammatory cytokines (tumor necrosis…
Read ArticleIn mice, hS significantly improved neurological function, reduced infarct volume, and increased cerebral blood flow in a dMCAO mouse model. These preclinical findings add evidence supporting molecular hydrogen's…
Read ArticleIn mice, hydrogen treatment upregulated SIRT1 expression and promoted PINK1/Parkin-mediated mitophagy, leading to reduced phosphorylation of STING, decreased levels of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α), and suppressed…
Read ArticleIn rabbits, hydrogen gas inhalation markedly improved lung endothelial permeability and decreased both MDA content and MPO activity in lung tissue; these changes were associated with decreases in…
Read ArticleIn C57BL/6 mice, levels of inflammatory cytokines (interleukin-1β, interleukin-6, and tumor necrosis factor α) and oxidative stress markers (ie, malondialdehyde) were significantly lower, whereas antioxidant enzyme (total superoxide…
Read ArticleIn mice, hydrogen inhalation increased the survival rate to 80%, reduced LPS-induced lung damage, and decreased inflammatory cytokine release in LPS mice. These preclinical findings add evidence supporting…
Read ArticleIn rats, after IRI, pulmonary function (pulmonary compliance and oxygenation levels) was significantly higher in the hydrogen-rich saline group than in the normal saline group ( P <…
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