Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation.

This animal study examined Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. The abstract reports: These results demonstrate that HS restored behavioral deficits after HI in neonatal mice. These beneficial effects, in part, involve promoting microglia M2 polarization and…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial.

This randomized controlled trial examined Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial. The abstract describes Human participants; hydrogen delivered as hydrogen water; reported duration 28 days. The abstract reports: Although preliminary, the results of this trial perhaps nominate HRW as an adjuvant treatment for mild-to-moderate NAFLD. These observations provide a rationale for further…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-Rich Saline Attenuates Acute Kidney Injury After Liver Transplantation via Activating p53-Mediated Autophagy.

This animal study examined Hydrogen-Rich Saline Attenuates Acute Kidney Injury After Liver Transplantation via Activating p53-Mediated Autophagy. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: HRS is able to protect against AKI after liver transplantation partly by reducing apoptosis, which is possibly involved in the modulation of p53-mediated autophagy. This is an automated editorial draft based on the abstract and requires source review before publication.

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Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen‐rich saline and N‐acetylcysteine treatments improves systemic, splanchnic and hepatic hemodynamics of cirrhotic rats

This animal study examined Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen‐rich saline and N‐acetylcysteine treatments improves systemic, splanchnic and hepatic hemodynamics of cirrhotic rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline; reported duration 1 month. The abstract reports: Both hydrogen-rich saline and N-acetylcysteine alleviate portal hypertension, the severity of portosystemic collaterals, mesenteric angiogenesis, hepatic endothelial dysfunction and intrahepatic resistance in cirrhotic rats.…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen treatment: a novel option in liver diseases.

This narrative review examined Hydrogen treatment: a novel option in liver diseases. The abstract describes Published literature review. This is an automated editorial draft based on the abstract and requires source review before publication.

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Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation

This observational study examined Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation. The abstract describes Human participants. The abstract reports: The data indicates E-HD could have substantial clinical benefits beyond conventional HD therapy, and support the rationale to conduct clinical trials of H2 application…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, -Glycoprotein, and Multidrug Resistance-Associated Protein 2 without Affecting Xenobiotic-Metabolizing Enzymes in Rat Liver.

This animal study examined Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, -Glycoprotein, and Multidrug Resistance-Associated Protein 2 without Affecting Xenobiotic-Metabolizing Enzymes in Rat Liver. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: The results showed that intake of HRW had no significant effect on the activities of various cytochrome P450 (CYP) enzymes (CYP1A1, 1A2, 2B, 2C,…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Aerosol inhalation of a hydrogen-rich solution restored septic renal function.

This animal study examined Aerosol inhalation of a hydrogen-rich solution restored septic renal function. The abstract describes Mouse model; hydrogen delivered as injected or infused hydrogen. This is an automated editorial draft based on the abstract and requires source review before publication.

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Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation.

This uncontrolled human study examined Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation. The abstract describes Human participants; hydrogen delivered as hydrogen-rich saline. The abstract reports: Hydrogen can attenuate severe burn-induced early AKI; the mechanisms of protection include the inhibition of oxidative stress induced apoptosis and inflammation, which may be…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Novel haemodialysis (HD) treatment employing molecular hydrogen (H)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study.

This observational study examined Novel haemodialysis (HD) treatment employing molecular hydrogen (H)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study. The abstract describes Human participants. The abstract reports: Multivariate analysis of the Cox proportional hazards model revealed E-HD as an independent significant factor for the primary endpoint (hazard ratio 0.59; [95% confidence…. This is an automated editorial draft based on the abstract and requires source review before publication.

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The immunological effects of electrolyzed reduced water on the Echinostoma hortense infection in C57BL/6 mice.

This animal study examined The immunological effects of electrolyzed reduced water on the Echinostoma hortense infection in C57BL/6 mice. The abstract describes Mouse model. The abstract reports: In the case of infected groups, the group fed ERW (ERW+E. hortense group) showed the result that IL-4, IL-5, IL-10 and Ig A expression…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-Rich Saline Ameliorates Allergic Rhinitis by Reversing the Imbalance of Th1/Th2 and Up-Regulation of CD4+CD25+Foxp3+Regulatory T Cells, Interleukin-10, and Membrane-Bound Transforming Growth Factor-β in Guinea Pigs

This animal study examined Hydrogen-Rich Saline Ameliorates Allergic Rhinitis by Reversing the Imbalance of Th1/Th2 and Up-Regulation of CD4+CD25+Foxp3+Regulatory T Cells, Interleukin-10, and Membrane-Bound Transforming Growth Factor-β in Guinea Pigs. The abstract describes Animal model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-rich water alleviates the toxicities of different stresses to mycelial growth in Hypsizygus marmoreus.

This animal study examined Hydrogen-rich water alleviates the toxicities of different stresses to mycelial growth in Hypsizygus marmoreus. The abstract describes Animal model; hydrogen delivered as hydrogen water. The abstract reports: Our results showed that HRW treatment, of which the H concentration was 0.8 mM, significantly reduced the toxicities of CdCl, NaCl and HO, leading to…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Intestinal Microbiota Ecological Response to Oral Administrations of Hydrogen-Rich Water and Lactulose in Female Piglets Fed a Toxin-Contaminated Diet.

This animal study examined Intestinal Microbiota Ecological Response to Oral Administrations of Hydrogen-Rich Water and Lactulose in Female Piglets Fed a Toxin-Contaminated Diet. The abstract describes Porcine model; hydrogen delivered as hydrogen water; reported duration 25 days. The abstract reports: Results showed that mycotoxins not only reduced the hydrogen levels in the caecum but also shifted the SCFAs production, and populations and communities of…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Protective Role of Hydrogen Gas on Oxidative Damage and Apoptosis in Intestinal Porcine Epithelial Cells (IPEC-J2) Induced by Deoxynivalenol: A Preliminary Study.

This in vitro or cellular study examined Protective Role of Hydrogen Gas on Oxidative Damage and Apoptosis in Intestinal Porcine Epithelial Cells (IPEC-J2) Induced by Deoxynivalenol: A Preliminary Study. The abstract describes Epithelial cell model. The abstract reports: Our results demonstrated that the 5 μM DON significantly caused cytotoxicity to IPEC-J2 cells by reducing cell viability and increasing lactate dehydrogenase release in…. This is an automated editorial draft based on the abstract and requires source review before publication.

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