Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet’s Disease and Sjögren’s Syndrome: A Case Report.

This case report or case series examined Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet’s Disease and Sjögren’s Syndrome: A Case Report. The abstract describes Human participants; hydrogen delivered as injected or infused hydrogen. The abstract reports: Molecular hydrogen may aid refractory oral ulcers in Behçet's and primary Sjögren's syndromes, with clinical and immunologic benefits. This is an automated editorial draft based on the abstract and requires source review before publication.

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Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis: A Pilot Study.

This uncontrolled human study examined Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis: A Pilot Study. The abstract describes Human participants; sample size 6; hydrogen delivered as hydrogen water. The abstract reports: The HW group showed greater improvements in probing pocket depth and clinical attachment level than the control group at two, four and eight weeks…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats.

This animal study examined Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats. The abstract describes Rat model; hydrogen delivered as hydrogen water. The abstract reports: Drinking HW significantly reduced neointima formation after vein grafting in rats. Drinking HW may have therapeutic value as a novel therapy for intimal hyperplasia…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Effects of hydrogen-rich water on aging periodontal tissues in rats.

This animal study examined Effects of hydrogen-rich water on aging periodontal tissues in rats. The abstract describes Rat model; sample size 12; hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.

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Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice.

This uncontrolled human study examined Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: However, H₂ supplementation does not result in detectable changes in striatal H₂ levels, indicating an indirect effect. This is an automated editorial draft based on the abstract and requires source review before publication.

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Efficacy of Oral Intake of Hydrogen-Rich Jelly Intake on Gingival Inflammation: A Double-Blind, Placebo-Controlled and Exploratory Randomized Clinical Trial.

This randomized controlled trial examined Efficacy of Oral Intake of Hydrogen-Rich Jelly Intake on Gingival Inflammation: A Double-Blind, Placebo-Controlled and Exploratory Randomized Clinical Trial. The abstract describes Human participants; reported duration 14 days. The abstract reports: However, no significant differences were found between groups ( > 0.05). : Administration of hydrogen-rich jelly for 14 days decreased gingival inflammation. This is an automated editorial draft based on the abstract and requires source review before publication.

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Using oral molecular hydrogen supplements to combat microinflammation in humans: a pilot observational study.

Persistent inflammation over time can cause gradual harm to the body. Molecular hydrogen has the potential to specifically counteract reactive oxygen species (ROS), reduce disease severity, and enhance overall health. Investigations of the anti-inflammatory and antioxidant properties of oral solid hydrogen capsules (OSHCs) are currently limited, prompting our examination of the beneficial effects of OSHCs.

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Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial

This uncontrolled human study examined Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: Investigation of oxidative stress markers such as reactive oxygen species and nitric oxide showed that their levels decreased post-treatment. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner.

This animal study examined Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPARα-dependent manner. The abstract describes Mouse model. The abstract reports: Finally, we found that H improved survival rates and brain dysfunction and decreased inflammatory cytokines. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen‐Rich Water Improves Cognitive Ability and Induces Antioxidative, Antiapoptotic, and Anti‐Inflammatory Effects in an Acute Ischemia‐Reperfusion Injury Mouse Model

This animal study examined Hydrogen‐Rich Water Improves Cognitive Ability and Induces Antioxidative, Antiapoptotic, and Anti‐Inflammatory Effects in an Acute Ischemia‐Reperfusion Injury Mouse Model. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: Hydrogen treatment could potentially be a future therapeutic strategy for ischemia and its derived neurodegenerative diseases by improving cognitive abilities and inducing antioxidative and…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and plasma metabolites of rats in health status.

This animal study examined Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and plasma metabolites of rats in health status. The abstract describes Rat model; hydrogen delivered as hydrogen water and hydrogen inhalation. The abstract reports: Pathway enrichment analysis showed that HRW intake mainly affected starch and sucrose metabolism, and DMs in HI group were mainly enriched in arginine biosynthesis. This is an automated editorial draft based on the abstract and requires source review before publication.

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Therapeutic Effects of Hydrogen Gas Inhalation on Trimethyltin-Induced Neurotoxicity and Cognitive Impairment in the C57BL/6 Mice Model.

This animal study examined Therapeutic Effects of Hydrogen Gas Inhalation on Trimethyltin-Induced Neurotoxicity and Cognitive Impairment in the C57BL/6 Mice Model. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation; reported duration 30 min. The abstract reports: Our results demonstrated that TMT exposure alters seizure and spatial recognition memory. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen water reduces NSE, IL-6, and TNF-α levels in hypoxic-ischemic encephalopathy.

This in vitro or cellular study examined Hydrogen water reduces NSE, IL-6, and TNF-α levels in hypoxic-ischemic encephalopathy. The abstract describes Cell culture / in vitro model; hydrogen delivered as hydrogen water; reported duration 10 days. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen Gas Treatment Improves Postoperative Delirium and Cognitive Dysfunction in Elderly Noncardiac Patients.

Purpose: Postoperative delirium is a state of acute brain dysfunction characterized by fluctuating mental status that affects millions of patients each year. We used prophylactic inhalation of hydrogen gas in elderly patients undergoing elective surgery to compare their occurrence of postoperative delirium with that of controls. Methods: A total of 184 patients aged ≥ 65 years were enrolled and randomized into either a control group or a hydrogen inhalation group.

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Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases

This animal study examined Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases. The abstract describes hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.

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