Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage.
This animal study examined Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation. The abstract reports: RESULTS: MGNs exhibited a two-dimensional structure and enabled sustained hydrogen release, particularly under acidic conditions. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Gas Treatment Improves the Neurological Outcome After Traumatic Brain Injury Via Increasing miR-21 Expression.
This animal study examined Hydrogen Gas Treatment Improves the Neurological Outcome After Traumatic Brain Injury Via Increasing miR-21 Expression. The abstract describes Rat model. The abstract reports: Here, we found that H2 treatment significantly increased the expression of miR-21 in brain from 6 h to 3 d after TBI. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen improves cell viability partly through inhibition of autophagy and activation of PI3K/Akt/GSK3β signal pathway in a microvascular endothelial cell model of traumatic brain injury.
This in vitro or cellular study examined Hydrogen improves cell viability partly through inhibition of autophagy and activation of PI3K/Akt/GSK3β signal pathway in a microvascular endothelial cell model of traumatic brain injury. The abstract describes Endothelial cell model. The abstract reports: More importantly, inhibition of PI3 K/Akt/GSK3β signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreGender-based differences in neuroprotective effects of hydrogen gas against intracerebral hemorrhage-induced depression.
This uncontrolled human study examined Gender-based differences in neuroprotective effects of hydrogen gas against intracerebral hemorrhage-induced depression. The abstract describes Human participants; reported duration 3 days. The abstract reports: Estrogen was responsible for increased H sensitivity in male mice with ICH. The underlying mechanism may be associated with the suppression of NF-κB signaling…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffects of intravenous infusion of hydrogen-rich fluid combined with intra-cisternal infusion of magnesium sulfate in severe aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial.
This study protocol examined Effects of intravenous infusion of hydrogen-rich fluid combined with intra-cisternal infusion of magnesium sulfate in severe aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial. The abstract describes Planned or registered research population; sample size 450; hydrogen delivered as injected or infused hydrogen. The abstract reports: Recent accumulating evidence has suggested that early brain injury is also involved in the development of delayed cerebral ischemia, and that hydrogen can prevent…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen inhalation therapy regulates lactic acid metabolism following subarachnoid hemorrhage through the HIF-1α pathway.
This uncontrolled human study examined Hydrogen inhalation therapy regulates lactic acid metabolism following subarachnoid hemorrhage through the HIF-1α pathway. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: The neuroprotective effects of hydrogen have been demonstrated, but the mechanism is still poorly understood. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen alleviates lung injury after traumatic brain injury: Pyroptosis and apoptosis.
This uncontrolled human study examined Molecular hydrogen alleviates lung injury after traumatic brain injury: Pyroptosis and apoptosis. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: H improves TBI-ALI, and the mechanism may be due to the decrease of both pyroptosis and apoptosis and the alleviation of inflammation. These findings…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreIntravenous Hydrogen Therapy With Intracisternal Magnesium Sulfate Infusion in Severe Aneurysmal Subarachnoid Hemorrhage
This randomized controlled trial examined Intravenous Hydrogen Therapy With Intracisternal Magnesium Sulfate Infusion in Severe Aneurysmal Subarachnoid Hemorrhage. The abstract describes Human participants; hydrogen delivered as injected or infused hydrogen; reported duration 14 days. The abstract reports: Intracisternal magnesium sulfate infusion started immediately after surgery reduces the incidence of cerebral vasospasm and delayed cerebral ischemia and improves clinical outcomes without complications…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreNeuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3β signaling pathway.
This in vitro or cellular study examined Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3β signaling pathway. The abstract describes Cell culture / in vitro model; hydrogen delivered as hydrogen-rich saline. The abstract reports: HS could attenuate neuronal apoptosis in EBI and improve the neurofunctional outcome after SAH, partially via the Akt/GSK3β pathway. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline injection into the subarachnoid cavity within 2 weeks promotes recovery after acute spinal cord injury.
This animal study examined Hydrogen-rich saline injection into the subarachnoid cavity within 2 weeks promotes recovery after acute spinal cord injury. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen; reported duration 2 weeks. The abstract reports: Results at 24 hours, 48 hours, 1 week and 2 weeks after injury showed that hydrogen-rich saline markedly reduced cell death, inflammatory cell infiltration,…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen saline suppresses neuronal cell apoptosis and inhibits the p38 mitogen‑activated protein kinase‑caspase‑3 signaling pathway following cerebral ischemia‑reperfusion injury.
This animal study examined Hydrogen saline suppresses neuronal cell apoptosis and inhibits the p38 mitogen‑activated protein kinase‑caspase‑3 signaling pathway following cerebral ischemia‑reperfusion injury. The abstract describes Rat model; sample size 60; hydrogen delivered as hydrogen-rich saline. The abstract reports: These results demonstrated that H2 significantly reduced the number of apoptotic cells, and the protein expression of p38 MAPK and caspase‑3, compared with the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.
This animal study examined Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury. The abstract describes Mouse model; hydrogen delivered as hydrogen water. The abstract reports: We found that mHW reversed CCI-induced edema by about half, completely blocked pathological tau expression, accentuated an early increase seen in several cytokines but…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreCombination of Hydrogen Inhalation and Hypothermic Temperature Control After Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care II Trial.
This randomized controlled trial examined Combination of Hydrogen Inhalation and Hypothermic Temperature Control After Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care II Trial. The abstract describes Human participants; sample size 39; hydrogen delivered as hydrogen inhalation. The abstract reports: The Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During Post-Cardiac Arrest Care (HYBRID) II trial (jRCTs031180352) suggested that hydrogen inhalation may…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury.
This uncontrolled human study examined Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury. The abstract describes Human participants; hydrogen delivered as hydrogen-rich saline. The abstract reports: Oxidative stress is the principal factor in traumatic brain injury (TBI) that initiates events that result in protracted neuronal dysfunction and remodeling. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas inhalation improves delayed brain injury by alleviating early brain injury after experimental subarachnoid hemorrhage.
This in vitro or cellular study examined Hydrogen gas inhalation improves delayed brain injury by alleviating early brain injury after experimental subarachnoid hemorrhage. The abstract describes Cell culture / in vitro model; hydrogen delivered as hydrogen inhalation. The abstract reports: CV showed no significant improvement between the control and H groups. This is an automated editorial draft based on the abstract and requires source review before publication.
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