Engineering a biomimetic bone scaffold that can regulate redox homeostasis and promote osteogenesis to repair large bone defects.
In an animal model, the released hydrogen gas can effectively regulate redox homeostasis and mitigate excessive inflammation, and the silicic acid can promote the proliferation of reparative cells and enhance their osteogenic differentiation, indicative of osteoinductivity. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreMolecular hydrogen enhances osteogenesis in Danio rerio embryos.
In zebrafish embryo, hydrogen-rich water (HRW) does not affect vitality or growth rate up to 15%. The authors concluded that, the researchers demonstrated the beneficial effects of hydrogen on anabolic bone functions in vivo. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreHydrogen gas distribution in organs after inhalation: Real-time monitoring of tissue hydrogen concentration in rat.
In rats, although animal and clinical studies have reported promising results, hydrogen distribution in organs after administration remains unclear. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreMolecular hydrogen downregulates acute exhaustive exercise-induced skeletal muscle damage.
In rats, exercise increased cleaved caspase-3 expression, and H₂ reduced this response. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen activates ACOD1-itaconate pathway to ameliorate steroid-associated osteonecrosis.
In mice, HRW-treated mice exhibit improved serum lipid profiles, including decreased levels of low-density lipoprotein (LDL), triglycerides (TG), and total cholesterol (T-CHO), as well as reduced lipid accumulation. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreEffect of CO2 and H2 gas mixture in cold water immersion on recovery after eccentric loading.
In 34 healthy participants, CO₂/H₂ cold-water immersion helped preserve isometric strength, countermovement-jump height, and range of motion after eccentric exercise compared with the other recovery conditions. Muscle soreness increased after exercise in every group, indicating that the recovery effect did not extend to every measured outcome. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence exercise performance and recovery in healthy adults.
Read MoreShould hydrogen therapy be included in a musculoskeletal medicine routine?
Initially proposed to be a possible treatment for certain types of neuromuscular disorders, cardio-metabolic diseases and cancer, H₂ improved clinical end-points and surrogate markers in several clinical trials, mainly acting as an anti-inflammatory agent and powerful antioxidant. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MorePilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes.
Adequate hydration with hydrogen-rich water pre-exercise reduced blood lactate levels and improved exercise-induced decline of muscle function. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreSupersaturated Hydrogen-Rich Water Hydrotherapy for Recovery of Acute Injury to the Proximal Phalanges on the 5th Toe: A Case Report
In 57 participants, this case is yet another indication that high-concentration hydrogen-rich hydrotherapy may be a helpful first line treatment in terms of reduction of pain and improvement in function following injury, in addition to the evidence suggesting benefit in reducing chronic indications caused by acute or chronic stress. These findings add human evidence that helps define the outcomes that did and did not change with molecular hydrogen in this study.
Read Moreosteoarthritis?
H2HUBB PLAIN-LANGUAGE TAKEAWAY The study adds to the molecular-hydrogen evidence base, but the available record does not support a firm conclusion about therapeutic benefit. Molecular hydrogen osteoarthritis study: what the findings mean This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. The publication “osteoarthritis?” was classified as a […]
Read MoreEffects of intraperitoneal hydrogen injection on nitric oxide synthase mRNA and malondialdehyde following limb ischemiareperfusion in rabbits
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreInvolvement of Neutrophil Dynamics and Function in Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness: Effect of Hydrogen Bath.
These results suggest that IL-6 may be involved in the mobilization of neutrophils into the peripheral blood and subsequent EIMD and DOMS after downhill running; however, it is not likely that H₂ bath is effective for the inflammatory process that was centered on neutrophils after downhill running. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreProtective Effect of Hydrogen Gas Inhalation on Muscular Damage Using a Mouse Hindlimb Ischemia-Reperfusion Injury Model.
In mice, infarct zone and area with loss of tissue structure and marked cellular infiltration were significantly decreased in groups treated by hydrogen gas inhalation during ischemia-reperfusion; however, these effects were not observed by posttreatment of hydrogen. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreA study on the protective effect of molecular hydrogen on osteoradionecrosis of the jaw in rats.
In Sprague-Dawley rats, the cell viability was significantly decreased after irradiation (P= 0.001), but pre-treatment with hydrogen before irradiation increased the cell viability (P= 0.025). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreIn vivo microelectrode monitoring of real-time hydrogen concentration in different tissues of rats after inhaling hydrogen gas.
In rats, hydrogen concentrations in the same tissue showed a dose-dependent response. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
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