Inhibitory effects of hydrogen on in vitro platelet activation and in vivo prevention of thrombosis formation.
In rats, hRS decreased P-selectin expression, release of thromboxane B2, ROS, and fibrinogen binding, but enhanced NO levels in H₂O₂-exposed platelets. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study.
In For human ex vivo studies, the researchers collected blood samples from six healthy humans and added normal saline or hydrogen-rich saline to blood and platelet-rich plasma, collagen-induced platelet aggregation was significantly decreased in H₂ gas and HS group rats (p=0.042, 0.018, respectively), while there was no difference in non-H₂ gas and NS group rats before and after treatment. The authors concluded that in summary, these data suggest that hydrogen may inhibit collagen-induced platelet aggregation. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreThe effect of hydrogen gas on a mouse bilateral common carotid artery occlusion.
In rats, however, the reduction of the expression of 8-OHdG, the decrease in the neuronal injury in the hippocampal CA1 sector, and the attenuation in brain water content were observed in hydrogen-treated mice. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreMolecular Hydrogen Reduces the Degree of Endothelial Alteration under Conditions of Chronic Heart Failure.
In a laboratory model, molecular hydrogen inhalations in both regimens caused a decrease in the number of circulating endothelial cells; the most pronounced effect was observed after repeated inhalations on day 14 after chronic heart failure modeling. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreMolecular hydrogen potentiates hypothermia and prevents hypotension and fever in LPS-induced systemic inflammation.
In male Wistar rats, during mild SI, H₂ reduced plasma surges of proinflammatory cytokines (TNF-α and IL-6) while caused an increase in plasma IL-10 (anti-inflammatory cytokine) and prevented fever. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects.
This preclinical study evaluated molecular hydrogen in rats. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen-Rich Saline Attenuates Brain Injury Induced by Cardiopulmonary Bypass and Inhibits Microvascular Endothelial Cell Apoptosis Via the PI3K/Akt/GSK3β Signaling Pathway in Rats.
Hydrogen improved microvascular endothelial-cell viability partly through PI3K/Akt/GSK3β activation and inhibition of autophagy in a traumatic-brain-injury model. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
Read MoreHydrogen Therapy in Cardiovascular and Metabolic Diseases: from Bench to Bedside.
This narrative review examined the available molecular-hydrogen literature. Hydrogen (H₂) is colorless, odorless, and the lightest of gas molecules. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreHYDROGEN PREVENTS LIPOPOLYSACCHARIDE-INDUCED PULMONARY MICROVASCULAR ENDOTHELIAL CELL INJURY BY INHIBITING STORE-OPERATED Ca 2+ ENTRY REGULATED BY STIM1/ORAI1.
In vitro, LPS treatment increased the expression levels of STIM1 and Orai1 in PMVECs, while H₂ reversed these changes. The authors concluded that the present study suggested that H₂ treatment alleviates LPS-induced PMVEC dysfunction by inhibiting store-operated Ca 2+ entry mediated by STIM1 and Orai1 in vitro and in vivo. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreHydrogen Gas Inhalation Prevents Erythrocyte Aggregation and Promotes Leukocyte Phagocytosis Together with Increases in Serum Antioxidant Activity
In a laboratory model, thus, 3%-hydrogen gas inhalation is suggested to potentially improve both the erythrocyte rheological/morphologic behaviors and the leucocyte phagocytosis-associated activity, concurrently with the enhanced antioxidant ability in blood. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
Read MoreInhalation of 2% Hydrogen Improves Survival Rate and Attenuates Shedding of Vascular Endothelial Glycocalyx in Rats with Heat Stroke.
In Wistar rats, serum levels of endotoxin, syndecan-1, malondialdehyde, and tumor necrosis factor-α decreased, whereas superoxide dismutase levels increased, indicating that inhalation of 2% hydrogen attenuated the damage to the vascular endothelial glycocalyx through its antioxidative and anti-inflammatory effects. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreAcute hydrogen-rich water ingestion stimulates cardiac autonomic activity in healthy females
In 14 healthy participants with crossover design, ln SDNN was significantly increased after HRW administration when compared to placebo in 45 min (HRW: 4.41 ± 0.42 ms, placebo: 4.28 ± 0.31 ms, p =.049) of rest sitting. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence cardiac autonomic regulation in healthy women.
Read MoreHydrogen Gas Inhalation Attenuates Endothelial Glycocalyx Damage and Stabilizes Hemodynamics in a Rat Hemorrhagic Shock Model.
In rats, H₂ and XOR-I both suppressed MAP reduction and improved survival rates. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreEffects of intraperitoneal hydrogen injection on nitric oxide synthase mRNA and malondialdehyde following limb ischemiareperfusion in rabbits
These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreThe synergistic potential of hydrogen inhalation and hyperbaric oxygen therapy
H2HUBB PLAIN-LANGUAGE TAKEAWAY The study adds to the molecular-hydrogen evidence base, but the available record does not support a firm conclusion about therapeutic benefit. Hydrogen inhalation blood pressure study: what the findings mean This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. The publication “The synergistic potential of […]
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