Editorial: Rehabilitation interventions for mild traumatic brain injury.
This publication is a scientific hypothesis or perspective about molecular hydrogen and identifies directions for further research.
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Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both.
This narrative review examined this study was designed to evaluate the effects of inhaled hydrogen or CO, or both, on cold ischemia/reperfusion (I/R) injury of the myocardium. Hydrogen…
Read ArticleHydrogen gas inhibits high-mobility group box 1 release in septic mice by upregulation of heme oxygenase 1.
In ICR mice with lipopolysaccharide-induced inflammation-related behavioral changes, however, therapy with H₂ increased the survival rate and alleviated the severity of lung injury, reduced the HMGB1 level, and…
Read ArticleHydrogen Gas Alleviates the Intestinal Injury Caused by Severe Sepsis in Mice by Increasing the Expression of Heme Oxygenase-1.
In mice, H₂ therapy in the animals with severe sepsis was associated with reduced intestinal injury, decreased numbers of colony-forming unit and apoptotic cells, reduced levels of biochemical…
Read Article[Role of Rho/ROCK signaling pathway in the protective effects of hydrogen against acute lung injury in septic mice].
In male C57BL/6 mice, lung HE staining showed that there were obvious lung injuries in the sepsis group which were alleviated in the H₂ treatment group. These preclinical…
Read ArticleHydrogen attenuates sepsis-associated encephalopathy by NRF2 mediated NLRP3 pathway inactivation.
In mice, hydrogen increased Nrf2 expression and inhibited the SAE-induced expression of NLRP3, caspase-1, cytokines IL-1β and IL-18, neuronal apoptosis, and mitochondrial dysfunction in WT mice but not…
Read ArticleRecent advances on endogenous gasotransmitters in inflammatory dermatological disorders.
This narrative review examined oF REVIEW: This review discusses the recent progress and will provide perspectives on endogenous gasotransmitters in the context of inflammatory dermatological disorders. The reviewed…
Read ArticleInjectable spontaneous hydrogen-releasing hydrogel for long-lasting alleviation of osteoarthritis.
In an animal model, from what has been discussed above, this injectable spontaneous H₂-releasing hydrogel is promising for OA treatment. These preclinical findings add evidence supporting molecular hydrogen's…
Read ArticleInhalation of hydrogen gas protects against mitomycin-induced pulmonary veno-occlusive disease.
In female Sprague-Dawley rats, inhaled H₂ improved hemodynamics and right heart function, reversed right ventricular hypertrophy, and prevented pulmonary vessel reconstitution in both prevention and treatment approaches. These…
Read ArticleCyanobacteria-probiotics symbionts for modulation of intestinal inflammation and microbiome dysregulation in colitis.
In mice, 3 G, preincubation of cells with ASp@BS under dark conditions led to a reduction in intracellular ROS, indicating that ASp@BS can effectively defend against oxidative stress…
Read ArticleHydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis.
In mice, the hydrolysis of CSNs produces anti-oxidative H₂, alkaline Ca(OH)2, and silica. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological…
Read ArticlePyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice.
In mice, this porous microsphere scaffold is implanted into bone defects to achieve the sustained release of hydrogen gas, magnesium ions (Mg2+), and dimethyl fumarate (DMF). These preclinical…
Read ArticleDietary addition of magnesium hydride nanoparticles: a breakthrough in combating high-fat diet-induced chronic kidney disease.
In conclusion, this study demonstrated that magnesium hydride functions as a safe and effective hydrogen source capable of inhibiting the activation of the transforming growth factor-beta/Smad2/3 and protein…
Read ArticleResearch on the inhibitory effect of hydrogen gas on ovarian cancer and potential mechanisms.
In The human ovarian cancer cell line SKOV3 was obtained from Central laboratory of the Affiliated Taian City Central Hospital of Qingdao University, at the same time, hydrogen…
Read ArticleHierarchical ROS-scavenging platform breaks vicious cycle of stem cell senescence, angiogenesis arrest, and immune dysregulation in diabetic wounds.
In diabetic murine models, this approach accelerated wound closure, enhanced neovascularization, and reduced inflammatory infiltration. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes…
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