[Research advances on hydrogen therapy in nervous system diseases].
This narrative review examined the available molecular-hydrogen literature. Recent studies have demonstrated that hydrogen has selective antioxidative effect. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreChemical and Biochemical Aspects of Molecular Hydrogen in Treating Kawasaki Disease and COVID-19.
This narrative review examined the available molecular-hydrogen literature. Kawasaki-like disease caused by COVID-19 shares some symptoms with KD, referred to as multisystem inflammatory syndrome in children, and has been reported in the United States, Italy, France, England, and other areas of Europe, with an almost 6-10 times or more increase compared with previous years of KD prevalence. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreThe role of hydrogen in the prevention and treatment of coronary atherosclerotic heart disease.
This narrative review examined the available molecular-hydrogen literature. Molecular hydrogen (H₂) is an effective anti-inflammatory agent and has potential to ameliorate glycolipid metabolism disorders, which is believed to exert beneficial effects on the prevention and treatment of CHD. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreElectrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with chronic haemodialysis.
In 42 patients with ERW for 1 year, the intracellular IL-2 and IFN-gamma levels in the Th1/Tc1 cells significantly (P < 0.05) increased and the intracellular IL-4, IL-6 and IL-10 levels in the Th2/Tc2 cells decreased. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation.
Read More[A study on residual strain of abdominal aortic aneurysm after intraperitoneal administration of saturated hydrogen saline in rats].
In male Sprague Dawley rats, saturated hydrogen saline can maintain good mechanical properties and reduce dilatation of the aorta by increasing residual strain and reducing the remodeling of it. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read More[Effect of hydrogen-rich saline on the CD4(+) CD25(+) Foxp3(+) Treg cells of allergic rhinitis guinea pigs model].
In guinea pigs, both the number and the cytokine secretion of CD4(+) CD25(+) Foxp3(+) Treg cells are decreased in AR group, hydrogen-rich saline may inhibit inflammatory response and ameliorate AR via improving the number and the cytokine secretion. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read More[Experimental studies of effects of hydrogen-rich saline in rats with severe acute pancreatitis].
In Sprague-Dawley rats, hydrogen-rich saline can decrease the levels of inflammatory mediators and reduce the pathological damage of pancreas through the inhibition of oxidative stress. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen-rich saline is cerebroprotective in a rat model of deep hypothermic circulatory arrest.
In rats, the administration of HRS resulted in a significant decrease in the brain injury, together with lower production of IL-1β, TNF-α, 8-OHdG and MDA as well as decreased activity of NOS while increased activity of SOD. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreIntrathecal infusion of hydrogen-rich normal saline attenuates neuropathic pain via inhibition of activation of spinal astrocytes and microglia in rats.
This publication is an erratum or correction associated with a molecular-hydrogen article. It does not report a new standalone experiment.
Read MoreAdministration of hydrogen-rich saline in mice with allogeneic hematopoietic stem-cell transplantation.
In BALB/c mice, this study proves that hydrogen-rich saline increased the survival rate, reduced clinical and histopathological scores of aGVHD, promoted the recovery of white blood cells, reduced the serum cytokine levels, and reversed tissue damage after transplantation in mice. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreProtective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury.
In male Sprague-Dawley rats, tumor necrosis factor-alpha (TNF-α) levels, malondialdehyde (MDA) concentrations, nuclear factor kappa B (NF-κB) p65 expression, and apoptosis index (AI) in I+HS group were significantly decreased (P < 0.05), while superoxide dismutase (SOD) activities were increased compared with those in I+NS group; and a marked improvement in alveolar structure was also found after hydrogen-rich saline treatment. The authors linked these findings to activation of the anti-inflammatory and antioxidant pathways. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreChanges in IL-4 and IL-13 expression in allergic-rhinitis treated with hydrogen-rich saline in guinea-pig model.
In guinea pigs, the frequencies of sneezing and scratching, as well as the levels of IgE, IL-4, and IL-13, in the serum were higher in the AR group than in the control group (p<0.01), whereas all these parameters were decreased significantly after hydrogen-rich saline treatment (p<0.05). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen-rich Saline is ineffective in oxygen-induced retinopathy.
In mice, kEY FINDING: The leakage and non-perfusion areas of retinal blood vessels were not alleviated in the HRS treatment group. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential for retinopathy and the biological pathways measured in this model.
Read MoreProtective Effect of Hydrogen-Rich Saline on Spinal Cord Damage in Rats.
In male Sprague Dawley rats, a decrease in apoptosis was also observed. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreBeneficial effects of hydrogen-rich saline against spinal cord ischemia-reperfusion injury in rabbits.
In rabbits, here, the researchers found that I/R-challenged rabbits exhibited significant spinal cord injury characterized by the decreased numbers of normal motor neurons and hind-limb motor dysfunction, which was significantly ameliorated by 5mL/kg and 10mL/kg HS treatment before reperfusion or 10mL/kg HS treatment after reperfusion. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
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