Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
In Sprague Dawley rats, antenatal H₂ administration may decrease the pulmonary mobility associated with inflammation in premature infants. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read ArticleThis narrative review examined the available molecular-hydrogen literature. However, a clinical trial showed that inhaling a mixture of 1.2–1.4% molecular hydrogen–air increased urinary 8-hydroxy-2′-deoxyguanosine, a marker of oxidative…
Read ArticleIn an animal model, hydrogen treatment during exposure to hyperoxia significantly improved blood oxygenation, reduced inflammatory events, and induced HO-1 expression. These preclinical findings add evidence supporting molecular…
Read ArticleIn mice, hydrogen gas did not alleviate LPS-induced liver injury under the conditions tested. These results are preclinical and suggest that molecular hydrogen did not improve the measured…
Read ArticleIn rats, after IRI, pulmonary function (pulmonary compliance and oxygenation levels) was significantly higher in the hydrogen-rich saline group than in the normal saline group ( P <…
Read ArticleIn mice, hydrogen gas inhalation increased NFκB DNA binding after 1h of ventilation and decreased NFκB DNA binding after 2h of ventilation, as compared with controls. These preclinical…
Read ArticleIn mice, however, H₂ did not substantially affect the H/R-induced increase in erythropoietin or pulmonary artery remodeling. These preclinical findings add evidence about the molecular-hydrogen effects, outcomes, and…
Read ArticleIn a laboratory model, hydrogen-rich saline treatment could inhibit apoptosis and inflammation while no significant reduction was observed in nitrogen-rich saline treated animals. The authors concluded that the…
Read ArticleIn rats, administration of hydrogen-rich saline or edaravone dramatically reduced the pulmonary levels of pulmonary inflammation mediators and myeloperoxidase. These preclinical findings add evidence supporting molecular hydrogen's therapeutic…
Read ArticleIn mice, these results demonstrate that molecular hydrogen treatment ameliorates LPS-induced ALI through reducing lung inflammation and apoptosis, which may be associated with the decreased NF-κB activity. These…
Read ArticleIn rats, hydrogen-rich saline improved the survival rate and attenuated pulmonary edema, injury, and apoptosis. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes…
Read ArticleIn rats, however, after treatment with HSS, all of these changes were alleviated (P < 0.05), and these changes were mitigated when treated with HSS by ip then…
Read ArticleIt has been suggested that saturated hydrogen saline may downregulate expression of nuclear factor (NF)-κB, leading to a decrease in Beclin-1 transcription and inhibition of autophagy. This source-grounded…
Read ArticleThis narrative review examined this study was to investigate the hypothesis that hydrogen could ameliorate CLP-induced lung injury in rats. Hydrogen-rich saline treatment significantly attenuated lung injury as…
Read ArticleIn rats, exposure to 1.3% hydrogen significantly attenuated the upregulation of the messenger RNAs for several proinflammatory mediators induced by HS/R. Hydrogen inhalation did not affect hemodynamic status…
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