Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
In male Sprague-Dawley rats, treatment with saturated hydrogen saline prolonged the median survival time of rats and reduced lung dysfunction induced by LPS. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this…
Read ArticleThe results indicated that PaO2, PaCO2, and T-SOD increased in the three treatment groups (P < 0.05), most significantly in the HOHS group (P < 0.01) compared with…
Read ArticleIn rats, at P1, LPS treatment decreased expressions of genes for FGFR4, VEGFR2, and HO-1 in the lungs, and hydrogen increased expressions of these genes. These preclinical findings…
Read ArticleIn male Sprague-Dawley rats, hydrogen water consumption reduced wet-to-dry weight ratio, malondialdehyde and myeloperoxidase activity and decreased the concentration of TNF-α, IL-1β, and IL-6 in the lung tissues…
Read ArticleIn male Sprague-Dawley rats, as shown in Figure 6B, the Nrf2 protein level increased significantly in the CS-challenged rat lungs as compared with that in the control (p<0.01),…
Read ArticleIn rats, hydrogen inhalation significantly reduced the number of inflammatory cells in the bronchoalveolar lavage fluid, and the mRNA and protein expression levels of tumor necrosis factor alpha,…
Read ArticleIn mice, hydrogen gas inhalation markedly upregulated the activity of decreased superoxide dismutase and significantly attenuated the increased level of malondialdehyde and myeloperoxidase. These preclinical findings add evidence…
Read ArticleIn a laboratory model, western blot analysis showed that hydrogen significantly upregulated the levels of phosphorylated AMPK (p-AMPK) and lowered the LPS-induced increased expression of dynamin-related protein 1…
Read ArticleThis narrative review examined the present review aims to provide a consistent summary of the findings of the last twenty years on the use of molecular hydrogen in…
Read ArticleIn 10 patients with chronic lung diseases due to COPD (n = 7), however, vitamin E, vitamin C, and nitrite levels showed a significant increase after 4 week…
Read ArticleThis publication is an erratum or correction associated with a molecular-hydrogen article. It does not report a new standalone experiment.
Read ArticleIn a laboratory model, hydrogen ameliorated cell injury and enhanced mitophagy in macrophages stimulated by LPS. The authors concluded that these results suggest that PINK1-mediated mitophagy plays a…
Read ArticleIn a mouse model of lipopolysaccharide-induced acute lung injury, inhalation of 66.7% hydrogen reduced lung pathological changes, pulmonary edema, pro-inflammatory cytokine release and oxidative-stress responses. These preclinical findings…
Read ArticleIn an animal model, however, BLM-induced oxidative stress was attenuated by H₂ inhalation therapy, which reduced the contents of reactive oxygen species, malondialdehyde and hydroxyproline, enhanced the activity…
Read ArticleIn a laboratory model, the expression of TNF-α was increased by 100 μmol/L vitamin C and 50 μmol/L vitamins E, separately or combined (P < 0.05), but not…
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