Hydrogen inhibits microglial activation and regulates microglial phenotype in a mouse middle cerebral artery occlusion model.
In mice, hCH attenuated brain injury and consequently reduced neurological dysfunction after I/R. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreRecent advances in hydrogen research as a therapeutic medical gas.
This narrative review examined currently available data regarding the protective role of hydrogen, provides an outline of recent advances in research on the use of hydrogen as a therapeutic medical gas in diverse models of disease and discusses the feasibility of hydrogen as a therapeutic strategy. Recent basic and clinical research has revealed that hydrogen is an important physiological regulatory factor with antioxidant, anti-inflammatory and anti-apoptotic protective effects on cells and organs. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreMolecular hydrogen suppresses Porphyromonas gingivalis lipopolysaccharide-induced increases in interleukin-1 alpha and interleukin-6 secretion in human gingival cells.
The results demonstrated that Pg LPS increased interleukin (IL) 1 alpha (IL-1α) and IL-6 secretion, but H₂ significantly suppressed the secretion of both cytokines without cytotoxicity. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreThe potential utilizations of hydrogen as a promising therapeutic strategy against ocular diseases.
This narrative review examined the available molecular-hydrogen literature. It is the authors' hope that the protective effects of hydrogen, as evidenced by these pioneering studies, would enrich the authors' pharmacological knowledge about this natural element and cast light into the discovery of a novel therapeutic strategy against ocular diseases. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreHigh-fat diet promotes epithelial-mesenchymal transition through enlarged growth of opportunistic pathogens and the intervention of saturated hydrogen.
In mice, after the treatment of saturated hydrogen, the changes in lung microbial population, lung tissue infiltration of inflammatory cells and the transformation of epithelial stroma caused by high-fat diet were moderately alleviated. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen inhalation therapy for inflammation and eye diseases: a review of the literature.
Hydrogen inhalation therapy for inflammation and eye diseases: a review of the literature is classified as Narrative review using Review or synthesis. The primary model is Published literature review. Detailed outcomes require source review because an abstract was not accessible.
Read MoreH2 Protects Against Lipopolysaccharide-Induced Cardiac Dysfunction via Blocking TLR4-Mediated Cytokines Expression.
In The mRNA levels of ANP and BNP were examined by PCR in vitro, lPS induced cardiac dysfunction; hydrogen therapy improved cardiac function after LPS challenge. The authors concluded that implications: Hydrogen therapy prevents LPS-induced cardiac dysfunction in part via downregulation of TLR4-mediated pro-inflammatory cytokines expression. These findings from a laboratory model add evidence supporting molecular hydrogen's biological and therapeutic potential in the model studied.
Read MoreTherapeutic Efficacy of Molecular Hydrogen: A New Mechanistic Insight.
This narrative review examined however, many reports on therapeutic applications of H₂ have the limitation to regard H₂ only as a scavenger for the hydroxyl radical and peroxynitrite. H₂ is proposed to convert the quinone intermediates to the fully reduced ubiquinol, thereby increasing the antioxidant capacity of the quinone pool as well as preventing the generation of ROS. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreHydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis.
This narrative review examined the available molecular-hydrogen literature. Studies have shown that H₂ inhalation has the therapeutic effects in many animal studies and clinical trials, and its application is recommended in the novel coronavirus pneumonia treatment guidelines in China recently. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreHydrogen as an innovative nootropic in health and disease.
This narrative review examined the available molecular-hydrogen literature. Despite the growing interest in H₂ as a potential therapeutic agent, the evidence regarding its potential as a nootropic remains limited. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreRole of Hydrogen in Atherosclerotic Disease: From Bench to Bedside.
This narrative review examined the available molecular-hydrogen literature. In this review, the researchers summarized the pathophysiological characteristics and risk factors associated with atherosclerosis (AS) and the laboratory research data that focuses on hydrogen to prevent and treat this condition, including the responses observed in both animal models and human studies. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreThe effects of hydrogen treatment in a cigarette smoke solution-induced chronic obstructive pulmonary disease-like changes in an animal model.
This publication is an erratum or correction associated with a molecular-hydrogen article. It does not report a new standalone experiment.
Read MoreNeuroprotective Effects of Molecular Hydrogen: A Critical Review.
This narrative review examined the available molecular-hydrogen literature. Further, H₂ is easy to use and has neuroprotective effects with no major side-effects, indicating that H₂ administration is a potential therapeutic strategy in clinical settings. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreMedical Application of Hydrogen in Hematological Diseases.
This narrative review examined the available molecular-hydrogen literature. Hydrogen gas has been reported to have medical efficacy since the 1880s. This review helps define the current molecular-hydrogen evidence and the outcomes reported across the literature it examined.
Read MoreIs It a Challenge to Use Molecular Hydrogen for Extending Flower Vase Life?
This narrative review examined the available molecular-hydrogen literature. Fortunately, improved tools involving molecular hydrogen can potentially improve postharvest products and storage. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
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