Hydrogen Gas Therapy in Schizophrenia: Potential Neuroprotective Effects From an Animal Study.
In male C57BL/6 mice, mK-801 administration significantly reduced HORAC levels, whereas hydrogen gas therapy markedly restored them. These preclinical findings add evidence about the molecular-hydrogen effects, outcomes, and biological pathways measured in this model.
Read MoreNanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
The researchers observed that anxiety/depression-like behaviors in experimental autoimmune encephalomyelitis (EAE) mice were alleviated by MgH2 treatment. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreEffects of hydrogen-rich water on depressive-like behavior in mice.
In an animal model, cUMS induced elevation in IL-1β protein levels in the hippocampus, and the cortex was significantly attenuated after 4 weeks of feeding the mice hydrogen-rich water. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreHydration Mechanism of the Hydrogen-Rich Water Based Cement Paste
This study examined Hydration Mechanism of the Hydrogen-Rich Water Based Cement Paste. The abstract describes hydrogen delivered as hydrogen water. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreFatigue disappearance in hemodialysis patients by dual approach with hydrogen gas inhalation and hydrogen-enriched dialysate: two case reports.
In 4 patients, 6 This suggests that a higher concentration of H₂ is necessary to achieve further improvements in fatigue. These findings add human evidence supporting molecular hydrogen's therapeutic potential for stroke recovery.
Read MoreHydrogen as a novel hypothesized emerging treatment for oxidative stress in autism
H2HUBB PLAIN-LANGUAGE TAKEAWAY The study adds to the molecular-hydrogen evidence base, but the available record does not support a firm conclusion about therapeutic benefit. Molecular hydrogen autism spectrum study: what the findings mean This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. The publication “Hydrogen as a novel […]
Read MoreMolecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia.
Specifically, both bipolar disorder and schizophrenia are associated with increased oxidative and inflammatory stress. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreNeuroprotective Effects of Molecular Hydrogen: A Critical Review.
This narrative review examined the available molecular-hydrogen literature. Further, H₂ is easy to use and has neuroprotective effects with no major side-effects, indicating that H₂ administration is a potential therapeutic strategy in clinical settings. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreEffects of hydrogen water and psychological treatment in a sample of women with panic disorder: a randomized and controlled clinical trial.
In participants, there was a further reduction in measured pro-inflammatory cytokine scores, improving body pain and physical health. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence inflammatory regulation.
Read MoreHydrogen gas post-conditioning alleviates cognitive dysfunction and anxiety-like behavior in a rat model of subarachnoid hemorrhage.
This publication is an erratum or correction associated with a molecular-hydrogen article. It does not report a new standalone experiment.
Read MoreGender-based differences in neuroprotective effects of hydrogen gas against intracerebral hemorrhage-induced depression.
In mice, compared with female mice, H₂ administration post-ICH exhibited fewer neuroprotective effects, including decreased sucrose consumption and time spent sniffing a novel mouse, increased immobility time, downregulated total SOD content, upregulated ROS content and p-NF-κB levels, and elevated astrocyte branches, whereas estrogen enhanced the neuroprotective effects of H₂ in male mice. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreLong-Term Neuroprotective Effects of Hydrogen-Rich Water and Memantine in Chronic Radiation-Induced Brain Injury: Behavioral, Histological, and Molecular Insights.
In male Sprague Dawley rats, pET/CT imaging showed increased hippocampal glucose uptake in the IR group, which was alleviated by HRW treatment. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreMolecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders.
This narrative review examined the available molecular-hydrogen literature. Since the landmark finding reported in 2007 found that hydrogen reduced the levels of peroxynitrite anions and hydroxyl free radicals in ischemic stroke, molecular hydrogen's antioxidative and anti-inflammatory effects have aroused widespread interest. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreTranscriptomic and metabolomic studies on the protective effect of molecular hydrogen against nuclear electromagnetic pulse-induced brain damage.
In rats, the data from the elevated plus maze and the open field test showed that NEMP exposure elicited anxiety-like behavior in rats, which could be alleviated by H₂ treatment. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreMolecular Hydrogen Reverses Nociplastic Pain and Depressive-like Behaviors via Region- and Sex-Dependent Central Mechanisms.
In female C57BL/6 mice, at the molecular level, HRW reduced spinal oxidative stress and ERK-dependent plasticity without altering spinal NLRP3 expression, whereas it fully reversed NLRP3 upregulation and HO-1 downregulation in the amygdala. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
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