[Role of Nrf2 in the protective effects of hydrogen against cerebral dysfunction in septic mice].
In mice, compared with the sham operation and hydrogen control groups, in the sepsis group, the number of normal pyramidal neurons in the hippocampal CA1 region was markedly reduced, the apoptotic index was marked increased, the expressions of nucleus and total Nrf2 were partly increased, the activities of SOD and CAT in the hippocampus were significantly decreased. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen-rich saline improves survival and neurological outcome after cardiac arrest and cardiopulmonary resuscitation in rats.
The researchers found that the beneficial effects of hydrogen-rich saline treatment were associated with decreased levels of oxidative products (8-iso-prostaglandin F2α and malondialdehyde) and inflammatory cytokines (tumor necrosis factor-α, interleukin-1β, and high-mobility group box protein 1), as well as the increased activity of antioxidant enzymes (superoxide dismutase and catalase) in serum and brain tissues. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreBeneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits.
In rabbits, here, the researchers found that I/R-challenged animals showed significant spinal cord damage characterized by the decreased numbers of normal motor neurons and hind-limb motor dysfunction, which was significantly improved by 2% and 4 % H₂ treatment. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen as a Potential Therapeutic in Obesity: Targeting the Brain.
This publication examined molecular hydrogen using the study design reported by the authoritative source. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreHydrogen-rich saline attenuates neuronal ischemiaereperfusion injury by protecting mitochondrial function in rats
H2HUBB PLAIN-LANGUAGE TAKEAWAY The study adds to the molecular-hydrogen evidence base, but the available record does not support a firm conclusion about therapeutic benefit. Hydrogen-rich saline mitochondrial function study: what the findings mean This H2HUBB page translates the technical study record into consumer-friendly language while preserving the scientific details. The publication “Hydrogen-rich saline attenuates neuronal […]
Read MoreHydrogen inhalation during normoxic resuscitation improves neurological outcome in a rat model of cardiac arrest independently of targeted temperature management.
In rats, neuronal degeneration and microglial activation in a vulnerable brain region was suppressed by both TTM alone and H₂ inhalation alone, with the combined therapy of TTM and H₂ inhalation being most effective. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreInhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by Protecting Spinal Cord Neurons from Apoptosis, Oxidative Injury and Mitochondrial Structure Damages.
In mice, spinal cord neurons were preserved by hydrogen administration after mechanical injury in a dose-dependent manner. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen-related enhancement of in vivo antioxidant ability in the brain of rats fed coral calcium hydride.
This animal study examined Hydrogen-related enhancement of in vivo antioxidant ability in the brain of rats fed coral calcium hydride. The abstract describes Rat model; reported duration 4 weeks. The abstract reports: These results clarify the mechanism that CCH may exert antioxidant activity by significantly enhancing the basal endogenous antioxidant ability in the hippocampus through a…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effects of hydrogen gas against spinal cord ischemia-reperfusion injury.
In male Sprague-Dawley rats, immunofluorescence indicated the expression of glutamate transporter-1 in the spinal ischemia group was significantly decreased compared with the sham group, which was attenuated by 3% hydrogen gas inhalation. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen therapy: from mechanism to cerebral diseases.
This narrative review examined the available evidence on molecular hydrogen. The medicinal value of hydrogen (H₂ ) was ignored prior to research illustrating that inhalation of 2% H₂ can significantly decrease the damage of cerebral ischemia/reperfusion caused by oxidative stress via selective elimination of hydroxyl freebase (OH) and peroxynitrite anion (ONOO-). The reviewed evidence supports molecular hydrogen's therapeutic potential. Additional well-designed studies are needed to clarify clinical safety and effectiveness.
Read MoreHydrogen Suppresses Hypoxia/Reoxygenation-Induced Cell Death in Hippocampal Neurons Through Reducing Oxidative Stress.
In a laboratory model, the levels of p-Akt (Ser 473) and Bcl-2 were significantly increased while Bax and cleaved caspase-3 were decreased by hydrogen treatment on the model of H/R. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
Read MoreHydrogen-rich Saline Alleviated the Hyperpathia and Microglia Activation via Autophagy Mediated Inflammasome Inactivation in Neuropathic Pain Rats.
In an animal model, focused on the mechanism and role of autophagy and inflammasome, by which hydrogen alleviated the hyperpathia induced by neuropathic pain. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen-rich water improves sleep consolidation and enhances forebrain neuronal activation in mice.
In mice, HRW increased sleep consolidation in undisturbed mice and increased non-rapid-eye movement and rapid-eye-movement sleep amount in sleep-deprived mice. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen-rich saline injection into the subarachnoid cavity within 2 weeks promotes recovery after acute spinal cord injury.
In rats, at 24 hours, 48 hours, 1 week and 2 weeks after injury showed that hydrogen-rich saline markedly reduced cell death, inflammatory cell infiltration, serum malondialdehyde content, and caspase-3 immunoreactivity, elevated serum superoxide dismutase activity and calcitonin gene-related peptide immunoreactivity, and improved motor function in the hindlimb. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreCapabilities of hydrogen molecules for use in the prevention and treatment in noise induced hearing loss
This narrative review examined literature concerning molecular hydrogen and its potential relevance to the auditory system, particularly the prevention and treatment of noise-induced hearing loss. The authors searched Medline, Google Scholar, PubMed, and SID and reviewed relevant textbooks and publications from 1973 through 2012.
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