Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice.
This animal study examined Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice. The abstract describes Mouse model; sample size 8. The abstract reports: Western blot analysis showed that coadministration of 1.3% hydrogen gas significantly (P < 0.001) reduced the level of neuronal apoptosis to approximately 40% compared…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe protective effects of hydrogen on HO-1 expression in the brainafter focal cerebral ischemia reperfusion in rats.
This animal study examined The protective effects of hydrogen on HO-1 expression in the brainafter focal cerebral ischemia reperfusion in rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline. The abstract reports: The results suggest that the neuroprotective effects of hydrogen may be mediated by promoting HO-1 expression and attenuated the oxidative injury. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen mitigates traumatic brain injury-induced lung injury via NLRP3 inflammasome inhibition.
This animal study examined Molecular hydrogen mitigates traumatic brain injury-induced lung injury via NLRP3 inflammasome inhibition. The abstract describes Mouse model. The abstract reports: 2% H can protect against TBI-induced lung injury by inhibiting NLRP3 inflammasome activation, thereby alleviating inflammation and inhibiting apoptosis. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMagnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage.
This animal study examined Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation. The abstract reports: RESULTS: MGNs exhibited a two-dimensional structure and enabled sustained hydrogen release, particularly under acidic conditions. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Gas Treatment Improves the Neurological Outcome After Traumatic Brain Injury Via Increasing miR-21 Expression.
This animal study examined Hydrogen Gas Treatment Improves the Neurological Outcome After Traumatic Brain Injury Via Increasing miR-21 Expression. The abstract describes Rat model. The abstract reports: Here, we found that H2 treatment significantly increased the expression of miR-21 in brain from 6 h to 3 d after TBI. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen improves cell viability partly through inhibition of autophagy and activation of PI3K/Akt/GSK3β signal pathway in a microvascular endothelial cell model of traumatic brain injury.
This in vitro or cellular study examined Hydrogen improves cell viability partly through inhibition of autophagy and activation of PI3K/Akt/GSK3β signal pathway in a microvascular endothelial cell model of traumatic brain injury. The abstract describes Endothelial cell model. The abstract reports: More importantly, inhibition of PI3 K/Akt/GSK3β signal pathway or activation of autophagy reduced the protective effect of hydrogen on cell viability, indicating that such protective…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas therapy improves survival rate and neurological deficits in subarachnoid hemorrhage rats: a pilot study.
This animal study examined Hydrogen gas therapy improves survival rate and neurological deficits in subarachnoid hemorrhage rats: a pilot study. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation; reported duration 2 hours. The abstract reports: Our results correlate well with the proposed mechanisms of hydrogen gas therapy within the literature. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas post‑conditioning attenuates early neuronal pyroptosis in a rat model of subarachnoid hemorrhage through the mitoKATP signaling pathway
This animal study examined Hydrogen gas post‑conditioning attenuates early neuronal pyroptosis in a rat model of subarachnoid hemorrhage through the mitoKATP signaling pathway. The abstract describes Rat model. The abstract reports: Therefore, these observations suggest that post-conditioning with hydrogen gas ameliorated SAH-induced neuronal pyroptosis at least in part through the mitoK/ERK1/2/p38 MAPK signaling pathway. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen exerts neuroprotection by activation of the miR‐21/PI3K/AKT/GSK‐3β pathway in an in vitro model of traumatic brain injury
This in vitro or cellular study examined Hydrogen exerts neuroprotection by activation of the miR‐21/PI3K/AKT/GSK‐3β pathway in an in vitro model of traumatic brain injury. The abstract describes PC12 cell model. The abstract reports: The results showed that hydrogen-rich medium improved neurite regeneration and inhibited apoptosis in the injured cells. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen‑rich saline promotes neuronal recovery in mice with cerebral ischemia through the AMPK/mTOR signal‑mediated autophagy pathway.
This animal study examined Hydrogen‑rich saline promotes neuronal recovery in mice with cerebral ischemia through the AMPK/mTOR signal‑mediated autophagy pathway. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEfficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial
This registered clinical trial examined Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial. The abstract describes Planned or registered research population; sample size 429; hydrogen delivered as hydrogen inhalation. The abstract reports: The trial was terminated prematurely because of the restrictions imposed on enrolment during the COVID-19 pandemic. Between February 1, 2017, and September 30, 2021,…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen alleviates lung injury after traumatic brain injury: Pyroptosis and apoptosis.
This uncontrolled human study examined Molecular hydrogen alleviates lung injury after traumatic brain injury: Pyroptosis and apoptosis. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: H improves TBI-ALI, and the mechanism may be due to the decrease of both pyroptosis and apoptosis and the alleviation of inflammation. These findings…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen inhalation inhibits microglia activation and neuroinflammation in a rat model of traumatic brain injury
This animal study examined Hydrogen inhalation inhibits microglia activation and neuroinflammation in a rat model of traumatic brain injury. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation. The abstract reports: Recent studies have demonstrated the potential neuroprotective effects of molecular hydrogen on TBI. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreEffects of a high concentration of hydrogen on neurological function after traumatic brain injury in diabetic rats.
This uncontrolled human study examined Effects of a high concentration of hydrogen on neurological function after traumatic brain injury in diabetic rats. The abstract describes Human participants. The abstract reports: We found that the inhalation of high concentrations of H significantly improved outcomes following TBI in diabetic rats. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline ameliorates hippocampal neuron apoptosis through up-regulating the expression of cystathionine β-synthase (CBS) after cerebral ischemia- reperfusion in rats.
This animal study examined Hydrogen-rich saline ameliorates hippocampal neuron apoptosis through up-regulating the expression of cystathionine β-synthase (CBS) after cerebral ischemia- reperfusion in rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline; reported duration 2 hr. The abstract reports: This study showed that hydrogen-rich saline ameliorates cell injury through up-regulating the expression of CBS in the hippocampus after cerebral ischemia reperfusion (I/R) in…. This is an automated editorial draft based on the abstract and requires source review before publication.
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