Influence of oxygen concentration on the neuroprotective effect of hydrogen inhalation in a rat model of cardiac arrest
This uncontrolled human study examined Influence of oxygen concentration on the neuroprotective effect of hydrogen inhalation in a rat model of cardiac arrest. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: In this CA rat model, inhaling 2% hydrogen combined with a high concentration of oxygen improved 96-h survival, either under normothermia or under hypothermia. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-rich saline improves survival and neurological outcome after cardiac arrest and cardiopulmonary resuscitation in rats.
This uncontrolled human study examined Hydrogen-rich saline improves survival and neurological outcome after cardiac arrest and cardiopulmonary resuscitation in rats. The abstract describes Human participants; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. The abstract reports: Hydrogen-rich saline treatment improved survival and neurological outcome after cardiac arrest/resuscitation in rats, which was partially mediated by reducing oxidative stress, inflammation, and apoptosis. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe neuroprotective effects of intraperitoneal injection of hydrogen in rabbits with cardiac arrest.
This animal study examined The neuroprotective effects of intraperitoneal injection of hydrogen in rabbits with cardiac arrest. The abstract describes Rabbit model; hydrogen delivered as injected or infused hydrogen. The abstract reports: Intraperitoneal injection of H2 is a novel hydrogen administration method and can reduce cerebral ischemia-reperfusion injury and improve the prognosis of cardiopulmonary cerebral resuscitation…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats.
This uncontrolled human study examined Hydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats. The abstract describes Human participants. The abstract reports: H therapy improved mortality in highly lethal CA rats rescued by ECPR and helped recover brain electrical activity. The underlying mechanism might be linked…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest Independently of Targeted Temperature Management
This animal study examined Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest Independently of Targeted Temperature Management. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation. The abstract reports: H2 inhalation was beneficial when begun after ROSC, even when delivered in the absence of hyperoxia. Combined TTM and H2 inhalation was more effective…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtection of the endothelium and endothelial glycocalyx by hydrogen against ischaemia-reperfusion injury in a porcine model of cardiac arrest.
This animal study examined Protection of the endothelium and endothelial glycocalyx by hydrogen against ischaemia-reperfusion injury in a porcine model of cardiac arrest. The abstract describes Porcine model; hydrogen delivered as hydrogen inhalation. The abstract reports: In pigs, hydrogen gas inhalation during CPR and post-resuscitation care was associated with less pronounced metabolic acidosis compared to controls. However, we could not…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreInhalation of high concentration hydrogen gas improves short-term outcomes in a rat model of asphyxia induced-cardiac arrest
This animal study examined Inhalation of high concentration hydrogen gas improves short-term outcomes in a rat model of asphyxia induced-cardiac arrest. The abstract describes Rat model; reported duration 1 hour. The abstract reports: Findings of this preclinical study suggest that water electrolysis-derived 60% hydrogen gas may improve short-term outcomes in cardiogenic global brain hypoxia-ischemia. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreThe protective effects of molecular hydrogen in sepsis-associated encephalopathy: current status.
This uncontrolled human study examined The protective effects of molecular hydrogen in sepsis-associated encephalopathy: current status. The abstract describes Human participants. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen-mediated SIRT1 activation alleviates sepsis-associated encephalopathy by promoting mitophagy
This animal study examined Molecular hydrogen-mediated SIRT1 activation alleviates sepsis-associated encephalopathy by promoting mitophagy. The abstract describes Mouse model. The abstract reports: This study demonstrates that inhalation of 2% H2 exerts significant protective effects against SAE, in which SIRT1 plays a pivotal role by modulating PINK1-dependent…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway.
This in vitro or cellular study examined Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway. The abstract describes Cell culture / in vitro model; hydrogen delivered as hydrogen inhalation. The abstract reports: Sepsis-associated encephalopathy (SAE) is the cognitive impairment resulting from sepsis and is associated with increased morbidity and mortality. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreAug 2019(mitochondrial dysfunction ,sepsis, autophagy)Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy-mediated NLRP3 inflammasome inactivation in sepsis
This animal study examined Aug 2019(mitochondrial dysfunction ,sepsis, autophagy)Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy-mediated NLRP3 inflammasome inactivation in sepsis. The abstract describes Mouse model. The abstract reports: The results demonstrated that LPS and ATP led to NLRP3 inflammasome pathway activation, excessive cytokine release, mitochondrial dysfunction and the activation of autophagy. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreChronic molecular hydrogen inhalation mitigates short and long-term memory loss in polymicrobial sepsis.
This uncontrolled human study examined Chronic molecular hydrogen inhalation mitigates short and long-term memory loss in polymicrobial sepsis. The abstract describes Human participants; hydrogen delivered as hydrogen inhalation. The abstract reports: Our results indicate that (1) chronic exposure of hydrogen gas is a simple, safe and promising therapeutic strategy to prevent memory loss in patients…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas presents a promising therapeutic strategy for sepsis.
This uncontrolled human study examined Hydrogen gas presents a promising therapeutic strategy for sepsis. The abstract describes Human participants. The abstract reports: Recently, some studies have found that molecular hydrogen is a new therapeutic gas. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Gas Protects Against Intestinal Injury in Wild Type But Not NRF2 Knockout Mice With Severe Sepsis by Regulating HO-1 and HMGB1 Release.
This animal study examined Hydrogen Gas Protects Against Intestinal Injury in Wild Type But Not NRF2 Knockout Mice With Severe Sepsis by Regulating HO-1 and HMGB1 Release. The abstract describes Mouse model. The abstract reports: The results showed that therapy with 2% H2 increased the survival rate, alleviated the injuries caused by oxidative stress and inflammation, reduced HMGB1 levels…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen-Rich Saline Regulates Intestinal Barrier Dysfunction, Dysbiosis, and Bacterial Translocation in a Murine Model of Sepsis.
This animal study examined Hydrogen-Rich Saline Regulates Intestinal Barrier Dysfunction, Dysbiosis, and Bacterial Translocation in a Murine Model of Sepsis. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline; reported duration 7 days. The abstract reports: In the results, the 7-day survival rate was significantly improved in the H2 group versus the control group (69% vs. This is an automated editorial draft based on the abstract and requires source review before publication.
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