Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
This narrative review examined the available molecular-hydrogen literature. reviewed the experimental and clinical findings of the effects of molecular hydrogen therapy in stroke patients and models. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes…
Read ArticleThe researchers observed that H(2) saline treatment reduced the caspase activity, MDA, Iba-1 levels, the infarct ratio, and improved the long-term neurological and neurobehavioral functions. These preclinical findings…
Read ArticleIn rats, the administration of HRS resulted in a significant decrease in the brain injury, together with lower production of IL-1β, TNF-α, 8-OHdG and MDA as well as…
Read ArticleIn moderate and severe neonatal HI models, hydrogen gas therapy (2.9% concentration H(2)) was not associated with decreased volume of infarction or decreased concentration of MDA. These preclinical…
Read ArticleIn rats, the edema area in TBI+HW group was slightly smaller than that of TBI group, and the surrounding edema was slightly reduced. These preclinical findings add evidence…
Read ArticleIn rats, the mRNA and protein expressions of AQP1 in cerebral cortex were significantly decreased after hydrogen-rich water treatment [24-hour AQP1 mRNA (2-△△Ct):5.40±0.21 vs.7.50±0.26, 24-hour AQP1 protein (gray…
Read ArticleIn rats, nSS scores in TBI and TBI+HW groups showed a decreased tendency with time prolongation after TBI. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential…
Read ArticleIn rats, hydrogen rich water can up-regulate the expression of Nrf2, and reduce oxidative damage of traumatic brain injury in rats. These preclinical findings add evidence supporting molecular…
Read ArticleIn male Sprague Dawley rats, hydrogen-rich saline can attenuate global cerebral I/R injure through inhibiting JNK, reducing the expression of FOXO3a. These preclinical findings add evidence supporting molecular…
Read ArticleThis narrative review examined the available molecular-hydrogen literature. Biological gaseous molecules including nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H2S), and molecular hydrogen (H₂) have been found…
Read ArticleIn contrast, H₂ treatment markedly increased NF-κB activity and the expression of Bcl-xL and decreased the level of cleaved caspase-3. These preclinical findings add evidence supporting molecular hydrogen's…
Read ArticleIn an animal model, here, the researchers found that HS treatment significantly reduced infarct volume and improved neurobehavioral outcomes at 24h, 48h and 72h after pMCAO operation in…
Read ArticleIn Sprague-Dawley rats, intragastric administration of lactulose substantially increased breath hydrogen concentration. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways…
Read ArticleHydrogen improved microvascular endothelial-cell viability partly through PI3K/Akt/GSK3β activation and inhibition of autophagy in a traumatic-brain-injury model. These findings come from a laboratory model and suggest molecular hydrogen's…
Read ArticleIn mice, the present study was designed to investigate whether hydrogen-rich saline (HS) attenuates HIBD in neonatal mice and whether the observed protection is associated with reduced endoplasmic…
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