Aug 2019(mitochondrial dysfunction ,sepsis, autophagy)Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy-mediated NLRP3 inflammasome inactivation in sepsis
This animal study examined Aug 2019(mitochondrial dysfunction ,sepsis, autophagy)Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy-mediated NLRP3 inflammasome inactivation in sepsis. The abstract describes Mouse model. The abstract reports: The results demonstrated that LPS and ATP led to NLRP3 inflammasome pathway activation, excessive cytokine release, mitochondrial dysfunction and the activation of autophagy. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen gas presents a promising therapeutic strategy for sepsis.
This uncontrolled human study examined Hydrogen gas presents a promising therapeutic strategy for sepsis. The abstract describes Human participants. The abstract reports: Recently, some studies have found that molecular hydrogen is a new therapeutic gas. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen Gas Protects Against Intestinal Injury in Wild Type But Not NRF2 Knockout Mice With Severe Sepsis by Regulating HO-1 and HMGB1 Release.
This animal study examined Hydrogen Gas Protects Against Intestinal Injury in Wild Type But Not NRF2 Knockout Mice With Severe Sepsis by Regulating HO-1 and HMGB1 Release. The abstract describes Mouse model. The abstract reports: The results showed that therapy with 2% H2 increased the survival rate, alleviated the injuries caused by oxidative stress and inflammation, reduced HMGB1 levels…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release.
This uncontrolled human study examined Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. The abstract describes Human participants. The abstract reports: Recently, it has been suggested that molecular hydrogen (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radicals (*OH, the most cytotoxic reactive…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen regulates mitochondrial quality to protect glial cells and alleviates sepsis-associated encephalopathy by Nrf2/YY1 complex promoting HO-1 expression.
This uncontrolled human study examined Hydrogen regulates mitochondrial quality to protect glial cells and alleviates sepsis-associated encephalopathy by Nrf2/YY1 complex promoting HO-1 expression. The abstract describes Human participants. The abstract reports: Hydrogen improved cell injury and mitochondrial quality, which were associated with HO-1 expression promoted by the Nrf2/YY1 complex in vitro. Thus, hydrogen treatment may…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreRecent Advances in Studies of Molecular Hydrogen against Sepsis.
This narrative review examined Recent Advances in Studies of Molecular Hydrogen against Sepsis. The abstract describes Published literature review. The abstract reports: Molecular hydrogen is a new type of antioxidant with strong free radical scavenging ability, which has been demonstrated to be effective for treating various…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreiTRAQ-Based Quantitative Proteomic Analysis of Intestines in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment.
This uncontrolled human study examined iTRAQ-Based Quantitative Proteomic Analysis of Intestines in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment. The abstract describes Human participants. The abstract reports: A total of 199 differential proteins were related with H in the intestinal protection of sepsis. H-related differential proteins were notably enriched in the…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MorePromising novel therapy with hydrogen gas for emergency and critical care medicine.
This narrative review examined Promising novel therapy with hydrogen gas for emergency and critical care medicine. The abstract describes Published literature review. The abstract reports: Studies undertaken by the Center have suggested possible therapeutic effects of hydrogen gas in relation to various aspects of emergency and critical care medicine,…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreRhupus Syndrome With Multiple Drug Intolerances Managed by Reduced-dose Rituximab and Adjunctive Molecular Hydrogen Therapy: A Case Report
This case report or case series examined Rhupus Syndrome With Multiple Drug Intolerances Managed by Reduced-dose Rituximab and Adjunctive Molecular Hydrogen Therapy: A Case Report. The abstract describes Human participants. The abstract reports: This case suggests molecular hydrogen therapy as a potential adjuvant for refractory Rhupus with multiple drug intolerances, showing immune modulation, reduced inflammation, steroid withdrawal,…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreH 2 inhalation therapy in patients with moderate COVID-19 (H 2 COVID): a prospective ascending-dose phase I clinical trial
This controlled human trial examined H 2 inhalation therapy in patients with moderate COVID-19 (H 2 COVID): a prospective ascending-dose phase I clinical trial. The abstract describes Human participants; sample size 12. The abstract reports: The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has triggered a serious global health crisis, resulting…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen(H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers
This uncontrolled human study examined Hydrogen(H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers. The abstract describes Human participants. The abstract reports: An improvement in acute erythemtous skin diseases followed the administration of H2 enriched fluid without compromising the safety. The H2 delivery study of two…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreMolecular hydrogen: a therapeutic antioxidant and beyond.
This uncontrolled human study examined Molecular hydrogen: a therapeutic antioxidant and beyond. The abstract describes Human participants. The abstract reports: Emerging evidence has consistently demonstrated that molecular hydrogen is a promising therapeutic option for a variety of diseases and the underlying comprehensive mechanisms is…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreProtective Effects of Hydrogen against Low‐Dose Long‐Term Radiation‐Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice
This animal study examined Protective Effects of Hydrogen against Low‐Dose Long‐Term Radiation‐Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice. The abstract describes Mouse model. The abstract reports: And significant differences between the treatment group and the radiation-only groups were observed, showing that H could diminish the detriment induced by LDLTR and…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen therapy can be used to control tumor progression and alleviate the adverse events of medications in patients with advanced non-small cell lung cancer.
This uncontrolled human study examined Hydrogen therapy can be used to control tumor progression and alleviate the adverse events of medications in patients with advanced non-small cell lung cancer. The abstract describes Human participants; sample size 10; reported duration 5 months. The abstract reports: According to the results of tumor-gene mutations and drug-sensitivity tests, 10, 18, and 10 patients were enrolled into chemotherapy, targeted therapy, and immunotherapy groups…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreA basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level
This uncontrolled human study examined A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level. The abstract describes Human participants; sample size 10; reported duration 30 min. The abstract reports: H2 inhalation of at least 3% concentration for 30 min delivered enough HC, equivalent to the animal experiment levels, in the blood without compromising…. This is an automated editorial draft based on the abstract and requires source review before publication.
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