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In mice, compared to RW and L-HRW, H-HRW resulted in a lower increase in fat mass (46% vs 61%), an increase in lean body mass (42% vs 28%), and a decrease in hepatic lipid accumulation (P < 0.01). These preclinical findings add…
Read ArticleIn rats, the mechanism of this phenomenon suggests that H₂ may have effectively attenuated AOC‐induced inflammatory and oxidative damage, and decreased matrix metalloproteinase activity. These preclinical findings add…
Read ArticleIn rats, the hydrogen-rich UW solution group also showed less oxidative damage and hepatocyte apoptosis than the control group, and the expression of proinflammatory cytokines tended to be…
Read ArticleIn mice, cCl(4) also significantly decreased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the…
Read ArticleIn mice, the HW group showed a smaller decrease in hepatic cholesterol; however, stronger antioxidative effects in serum and lower peroxisome proliferator-activated receptor-α expression in the liver were…
Read ArticleIn an animal model, liver samples in the group with inhaled hydrogen showed a statistically significant reduction in histological changes compared to the control group. These preclinical findings…
Read ArticleIn an animal model, apoptosis in cholangiocytes isolated from a rat model of liver ischemia/reperfusion injury indicated that H₂ significantly attenuates ischemia/reperfusion cholangiocyte injury in vivo. These preclinical…
Read ArticleIn mice, HRW attenuated malondialdehyde level, restored glutathione depletion and increased superoxide dismutase, glutathione peroxidase and catalase activities in the liver. These preclinical findings add evidence supporting molecular…
Read ArticleIn mice, when compared to C group, both the Model group and the HRW group showed a significant reduction in the protein expression levels of iron death-related markers…
Read ArticleIn Sprague-Dawley rats, long-term HRW consumption significantly reduced LPS-induced inflammatory cell infiltration in liver tissue, suppressed the abnormal elevation of pro-inflammatory factors, and maintained relatively stable expression levels…
Read ArticleIn mice, among these, Acaca, Fasn, and CD36 were decreased ( Figures 2G-I ), while Mttp and Apob were increased by high dose H₂ therapy ( Figures 2N,O…
Read ArticleIn the present study, the researchers found that HRCC treatment improved methionine-and-choline-deficient diet (MCD)-induced hepatic steatosis, increased aspartate aminotransferase and alanine aminotransferase levels, and elevated hepatic inflammatory factor…
Read ArticleIn mice, H₂ inhalation improved gut microbiota, including increasing the abundance of Lachnospiraceae and Clostridia, and decreasing the abundance of Prevotellaceae and Muribaculaceae, and also improved intestinal barrier…
Read ArticleIn mice, intraperitoneal injection of H₂ improved acute ethanol-induced liver injury in mice in a dose dependent manner, as indicated by decreasing serum ALT and AST levels, hepatic…
Read ArticleIn rats, rats exposed 2 h daily to H₂ either by drinking HRW (H₂ dissolved in H₂O) or by breathing 4% H₂ gas showed reduced lipogenesis and enhanced…
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