Research-informed education, independent testing, and practical guidance across the evolving science and application of molecular hydrogen.
Explore H2HUBB articles covering molecular hydrogen research, hydrogen water, hydrogen inhalation, dosing, product testing, safety, technology, and practical education for consumers and the hydrogen industry.
In rats, H₂ significantly suppressed increases in blood pressure after 5/6 nephrectomy. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read ArticleIn mice, intrathecal delivery of recombinant CXCL1 induces acute allodynia and spinal iron overload, which is reversed by hydrogen-rich water. These preclinical findings add evidence supporting molecular hydrogen's…
Read ArticleIn an animal model, an in vitro study performed on RAW264.7 murine cells showed that H₂ treatment prevents RANKL-associated osteoclastogenesis, inhibiting the inactivation of NF-kB, mitogen-activated protein kinase…
Read ArticleIn mice, H₂ treatment reduced inflammatory, oxidative, and fibrotic lung changes. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured…
Read ArticleIn mice, the immunofluorescence of cleaved caspase-3 also indicated that H₂ suppressed the expression of cleaved caspase-3 in TBHP-induced chondrocytes ( Figure 5H ). These preclinical findings add…
Read ArticleIn rats, mDA and 8-OHdG were significantly decreased in hydrogen-rich medium, while SOD and GSH were increased. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within…
Read ArticleIn male Sprague-Dawley rats, the wet/dry ratio increased significantly in the IR group (P < 0.01 compared with that in the sham group) and decreased significantly in IR…
Read ArticleIn mice, the amount of trabecular bone and bone mineral density of OVX mice that inhaled H₂ were more than 40% higher, whereas the levels of serum proinflammatory…
Read ArticleIn rats, drinking hydrogen-rich water suppressed body weight gain, lowered gingival level of 8-hydroxydeoxyguanosine, and reduced alveolar bone resorption in rats on a high-fat diet. These preclinical findings…
Read ArticleIn mice, based on the authors' result, H₂ enriched medium can increase super oxide dismutase (SOD) level following H₂O₂ treatment and decrease 8-hydroxy-2'-deoxyguanosine (8-OHdG) level. These preclinical findings…
Read ArticleIn an animal model, the number of senescence-associated β-galactosidase (SA-β-Gal) positive cells was reduced in BMSCs from rats treated with HRS. These preclinical findings add evidence supporting molecular…
Read ArticleIn rabbits, hydrogen-rich saline significantly decreased the levels of VEGF, TM and LPO and increased the GSH level in steroid-associated necrosis of the femoral head in the rabbit…
Read ArticleIn rats, treatment with HW abated oxidative stress and suppressed IL-6 and TNF-α mRNA expressions in femur of ovariectomized rats; treatment with HW increased femur endothelial NOS activity…
Read ArticleIn rats, hW showed a protective effect against the progression of OA in an animal model, which may have been mediated by its anti-oxidant and anti-apoptotic activities. These…
Read ArticleIn Sprague-Dawley rats, treatment with HW alleviated HLS-induced reduction of bone mineral density, ultimate load, stiffness, and energy in femur and lumbar vertebra. These preclinical findings add evidence…
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