iTRAQ-Based Quantitative Proteomic Analysis of Intestines in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment.

This uncontrolled human study examined iTRAQ-Based Quantitative Proteomic Analysis of Intestines in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment. The abstract describes Human participants. The abstract reports: A total of 199 differential proteins were related with H in the intestinal protection of sepsis. H-related differential proteins were notably enriched in the…. This is an automated editorial draft based on the abstract and requires source review before publication.

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High-concentration hydrogen inhalation mitigates sepsis-associated encephalopathy in mice by improving mitochondrial dynamics.

This animal study examined High-concentration hydrogen inhalation mitigates sepsis-associated encephalopathy in mice by improving mitochondrial dynamics. The abstract describes Mouse model; hydrogen delivered as hydrogen inhalation. The abstract reports: Inhalation of high concentration (67%) of H in septic mice improved the survival rate and reduced neuronal injury. Its mechanism might be mediated by…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen‐rich and hyperoxygenate saline inhibits lipopolysaccharide‐induced lung injury through mediating NF‐κB/NLRP3 signaling pathway in C57BL/6 mice

This animal study examined Hydrogen‐rich and hyperoxygenate saline inhibits lipopolysaccharide‐induced lung injury through mediating NF‐κB/NLRP3 signaling pathway in C57BL/6 mice. The abstract describes Mouse model; hydrogen delivered as injected or infused hydrogen. The abstract reports: Hydrogen plays a more important role in the inflammatory and anti-apoptosis mechanisms, while oxygen improves hypoxia of the body, and thus, its molecular mechanism…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Safety of inhaled hydrogen gas in healthy mice.

This animal study examined Safety of inhaled hydrogen gas in healthy mice. The abstract describes Mouse model; sample size 25; hydrogen delivered as hydrogen inhalation; reported duration 72 hours. This is an automated editorial draft based on the abstract and requires source review before publication.

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Protective Effects of Hydrogen against Low‐Dose Long‐Term Radiation‐Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice

This animal study examined Protective Effects of Hydrogen against Low‐Dose Long‐Term Radiation‐Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice. The abstract describes Mouse model. The abstract reports: And significant differences between the treatment group and the radiation-only groups were observed, showing that H could diminish the detriment induced by LDLTR and…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Pharmacokinetics of a single inhalation of hydrogen gas in pigs.

This animal study examined Pharmacokinetics of a single inhalation of hydrogen gas in pigs. The abstract describes Animal model. This is an automated editorial draft based on the abstract and requires source review before publication.

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Biological safety of neutral-pH hydrogen-enriched electrolyzed water upon mutagenicity, genotoxicity and subchronic oral toxicity

This animal study examined Biological safety of neutral-pH hydrogen-enriched electrolyzed water upon mutagenicity, genotoxicity and subchronic oral toxicity. The abstract describes Rat model; reported duration 28 days. The abstract reports: Hydrogen-dissolved water has been suggested to be effective for alleviating the oxidative stress. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma.

This animal study examined Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma. The abstract describes Mouse model; hydrogen delivered as hydrogen-rich saline. The abstract reports: These findings suggest that hydrogen-rich saline reduces airway inflammation and remodeling in OVA-exposed mice by inhibiting NF-κB. This is an automated editorial draft based on the abstract and requires source review before publication.

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Pharmacokinetics of Hydrogen During Hydrogen-Saturated Saline Infusion in Pigs.

This animal study examined Pharmacokinetics of Hydrogen During Hydrogen-Saturated Saline Infusion in Pigs. The abstract describes Animal model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen inhalation: in vivo rat genotoxicity tests.

This animal study examined Hydrogen inhalation: in vivo rat genotoxicity tests. The abstract describes Rat model; hydrogen delivered as hydrogen inhalation. This is an automated editorial draft based on the abstract and requires source review before publication.

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Pharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: A study in pigs.

This animal study examined Pharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: A study in pigs. The abstract describes Animal model; hydrogen delivered as hydrogen water and injected or infused hydrogen; reported duration 120 min. This is an automated editorial draft based on the abstract and requires source review before publication.

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Protective Effects of a Hydrogen-Rich Preservation Solution in a Canine Lung Transplantation Model.

This animal study examined Protective Effects of a Hydrogen-Rich Preservation Solution in a Canine Lung Transplantation Model. The abstract describes Canine model; reported duration 4 hours. The abstract reports: Our results demonstrated that the H-rich preservation solution attenuated ischemia-reperfusion injury in a canine left LTx model. This is an automated editorial draft based on the abstract and requires source review before publication.

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Molecular Hydrogen Ameliorates Anti-Desmoglein 1 Antibody-Induced Pemphigus-Associated Interstitial Lung Disease by Inhibiting Oxidative Stress.

This uncontrolled human study examined Molecular Hydrogen Ameliorates Anti-Desmoglein 1 Antibody-Induced Pemphigus-Associated Interstitial Lung Disease by Inhibiting Oxidative Stress. The abstract describes Human participants; hydrogen delivered as hydrogen water. The abstract reports: Using a BALB/cJGpt mouse model, we demonstrated that anti-Dsg 1 antibodies, but not anti-Dsg 3 antibodies, induced interstitial inflammation and fibrosis. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats.

This animal study examined Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats. The abstract describes Rat model; hydrogen delivered as hydrogen-rich saline and injected or infused hydrogen; reported duration 12 weeks. The abstract reports: ELISA assay showed hydrogen-rich saline lowered the levels of pro-inflammatory cytokines (IL-8 and IL-6) and anti-inflammatory cytokine IL-10 in bronchoalveolar lavage fluid and serum…. This is an automated editorial draft based on the abstract and requires source review before publication.

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Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats.

This animal study examined Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. The abstract describes Rat model; sample size 30; hydrogen delivered as hydrogen-rich saline. The abstract reports: Hydrogen-rich saline attenuates lung injury induced by intestinal I/R. This is an automated editorial draft based on the abstract and requires source review before publication.

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