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In rats, the Si-based agent was found to effectively suppress I/R injury in skin flaps, and allow for the production of a large amount of hydrogen continuously via oral administration with a low likelihood of adverse events. These preclinical findings add evidence…
Read ArticleIn rats, prophylactic instillation of hydrogen suppressed alkali burn-induced oxidative stress of the cornea and promoted wound healing. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential…
Read ArticleIn dogs, HRW treatment promoted skin wound healing in dogs, accelerated wound epithelization, reduced inflammatory reaction, stimulated the expression of cytokines related to wound healing, and shortened wound…
Read ArticleIn Sprague-Dawley rats, repeated HRS injections after trauma increased the viability of skin flap in rat degloving injury model by decreasing local tissue injury, due to its antioxidant,…
Read ArticleIn male Sprague-Dawley rats, rIP1, RIP3, MLKL, PGAM5 and Drp1 were expressed at high levels in the IR group, and their expression was significantly decreased in the HCH…
Read ArticleIn mice, hydrogen treatment upregulated SIRT1 expression and promoted PINK1/Parkin-mediated mitophagy, leading to reduced phosphorylation of STING, decreased levels of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α), and suppressed…
Read ArticleIn an animal model, the incidence of bacterial translocation at 24 h after CLP as assessed by cultivation of mesenteric lymph nodes and blood was significantly decreased in…
Read ArticleIn mice, therapy with 2% H₂ increased the survival rate, alleviated the injuries caused by oxidative stress and inflammation, reduced HMGB1 levels but increased HO-1 levels in WT…
Read ArticleIn vitro assays showed that burn serum reduced fibroblast proliferation and increased apoptosis (P < 0.01), which hydrogen gas mitigated by rescuing cell viability and reducing apoptosis (P…
Read ArticleIn mice, molecular hydrogen treatment improved gut microbiota dysbiosis and partially amended metabolic disorder after SAE. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the…
Read ArticleIn mice, the load of blood and peritoneal lavage bacteria was increased, and H₂ treatment can significantly reduce it. These preclinical findings add evidence supporting molecular hydrogen's therapeutic…
Read ArticleIn mice, inhalation of 67% H₂ improved the 7-day survival rates and recognition memory function of septic mice, alleviated brain antioxidant enzyme activity (SOD and CAT), and reduced…
Read ArticleThe researchers observed that the combined protective effect of hydrogen and oxygen was superior to their respective protective effects, and the specific molecular mechanisms of the two therapies…
Read ArticleIn mice, similarly, there was no significant change in the total SHIRPA score, although hydrogen-treated mice exhibited significantly lower spontaneous locomotor activity (P 0.05 for all). These preclinical…
Read ArticleThe results demonstrated that H₂ treatment reduced the immobility time in the FST ( Figure 3, F = 4.449, p = 0.038). These preclinical findings add evidence supporting…
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