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919 Articles

PPARα contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression.

By H2HUBB Jul 22, 2026 0 Comments

The results showed the expression of PPARα was decreased in SAE mice and that activation of PPARα in septic mice improved the survival rate and alleviated cognitive dysfunction. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and…

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Impact of hydrogen gas inhalation during therapeutic hypothermia on cerebral hemodynamics and oxygenation in the asphyxiated piglet.

By H2HUBB Jul 22, 2026 0 Comments

In conclusion, combined H₂ gas ventilation and TH increased CBV and decreased ScO2, which may reflect elevated cerebral blood flow to meet greater oxygen demand for the surviving…

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Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity.

By H2HUBB Jul 22, 2026 0 Comments

In an animal model, hydrogen-rich saline treatment significantly reduced the level of degraded myelin basic protein, decreased the expression of ionized calcium-binding adapter molecule 1, Iba1, a microglial…

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Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine.

By H2HUBB Jul 22, 2026 0 Comments

In an animal model, this study used a swine model of mildly hypothermic prolonged circulatory arrest and found that the addition of 2.4% inhaled hydrogen gas to inspiratory…

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The neuroprotective effect of hyperoxygenate hydrogen-rich saline on CO-induced brain injury in rats.

By H2HUBB Jul 22, 2026 0 Comments

In male Sprague-Dawley rats, however, HOS and HOHS significantly decreased COHb contents, furthermore, the HOHS group had lower COHb contents than the HOS group. These preclinical findings add…

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Hydrogen-rich water improves sleep consolidation and enhances forebrain neuronal activation in mice.

By H2HUBB Jul 22, 2026 0 Comments

In mice, HRW increased sleep consolidation in undisturbed mice and increased non-rapid-eye movement and rapid-eye-movement sleep amount in sleep-deprived mice. These preclinical findings add evidence supporting molecular hydrogen's…

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Hydrogen inhalation exerts anti-seizure effects by preventing oxidative stress and inflammation in the hippocampus in a rat model of kainic acid-induced seizures.

By H2HUBB Jul 22, 2026 0 Comments

In rats, pretreatment with H₂ inhalation significantly attenuated seizure intensity; prevented neuronal loss; decreased microglial and astrocytic activation; decreased ROS, TNF-α, IL-1β, IL-6, CCL2 and CCL3 levels; and…

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Transcriptomic and metabolomic studies on the protective effect of molecular hydrogen against nuclear electromagnetic pulse-induced brain damage.

By H2HUBB Jul 22, 2026 0 Comments

In rats, the data from the elevated plus maze and the open field test showed that NEMP exposure elicited anxiety-like behavior in rats, which could be alleviated by…

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Hyperbaric hydrogen therapy improves secondary brain injury after head trauma.

By H2HUBB Jul 22, 2026 0 Comments

In mice, hyperbaric hydrogen therapy may be effective for posttraumatic secondary brain injury. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological…

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Phosphorylation-mediated PI3K-Art signalling pathway as a therapeutic mechanism in the hydrogen-induced alleviation of brain injury in septic mice.

By H2HUBB Jul 22, 2026 0 Comments

In mice, 5 In the present study, the researchers quantitatively assessed the changes in protein phosphorylation in the H₂ ‐treated CLP model mice and identified functions and signalling…

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Hydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through the Activation of PGC-α in Mice.

By H2HUBB Jul 22, 2026 0 Comments

In mice, the present study showed that hydrogen gas therapy increased the 7-day survival rate, improved cognitive function, increased the mitochondrial function (MMP, ATP level, complex I activity)…

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Use of molecular hydrogen as an energy substrate by human pathogenic bacteria.

By H2HUBB Jul 22, 2026 0 Comments

In mice, molecular hydrogen is produced as a fermentation by-product in the large intestine of animals and its production can be correlated with the digestibility of the carbohydrates…

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Therapeutic effects of hydrogen-rich solution on aplastic anemia in vivo.

By H2HUBB Jul 22, 2026 0 Comments

In mice, the number of CD4(+) and CD8(+) cells as well as the ratio of CD4/CD8 increased to normal gradually, while the levels of TNF-α, IFN-γ, and IL-6…

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Neuroprotective and Preventative Effects of Molecular Hydrogen.

By H2HUBB Jul 22, 2026 0 Comments

In mice, there are several mechanisms of how H₂ protects neuronal damage. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways…

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Molecular Hydrogen Reverses Nociplastic Pain and Depressive-like Behaviors via Region- and Sex-Dependent Central Mechanisms.

By H2HUBB Jul 22, 2026 0 Comments

In female C57BL/6 mice, at the molecular level, HRW reduced spinal oxidative stress and ERK-dependent plasticity without altering spinal NLRP3 expression, whereas it fully reversed NLRP3 upregulation and…

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