MAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase of acute pancreatitis.
In a laboratory model, the subsequent in vitro experiments showed that H₂ treatment inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK, and activated NF-κB and the expression of tumor necrosis factor α and interleukin-1β, while simultaneously preventing the translocation of phospho-ERK, phospho-JNK, and phospho-p38 from the cytoplasm to the nucleus. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
Read MoreMechanism of hydrogen-rich water alleviating radiation-induced cognitive impairment through PI3K/AKT/Caspase-9 pathway mediating anti-oxidation.
The results of the Morris water maze test showed that compared with the IR group, the escape latency of the rats in the IR + LHRW group and the IR + HHRW group was shortened, among which, on the 5th day, the IR + HHRW group had a significant difference. On the 6th day, compared with the Control group, the time for Explore the mechanism by which the antioxidant effect of hydrogen-rich water alleviates radiation-induced cognitive impairment based on the PI3K/AKT/Caspase-9 signaling pathway. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read More富氢水抑制离心运动后骨骼肌线粒体氧化应激和炎症反应
In Sprague Dawley rats, the study examined whether hydrogen-rich water could protect skeletal muscle from eccentric-exercise injury and explored the underlying mechanisms. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen gas inhalation alleviated cerebral ischemia/reperfusion injury by regulating mitophagy in SH-SY5Y cells and mice via PTEN-induced kinase 1/Parkin pathway.
In SH-SY5Y cells, H₂ treatment significantly improved cell viability, attenuated oxidative stress and mitochondrial dysfunction, and enhanced mitophagy via activation of the PINK1/Parkin pathway. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreZn-Fe primary battery-enabled controlled hydrogen release in stomach for improving insulin resistance in obesity-associated type 2 diabetes.
In vivo monitoring results show that H₂ generated by Zn-Fe micro-/nano-structure in stomach can effectively accumulate in IR-sited tissues including liver, adipose tissue, and skeletal muscle at a high dose for a relatively long time compared to H₂-rich water drinking. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen-rich saline improves survival and neurological outcome after cardiac arrest and cardiopulmonary resuscitation in rats.
The researchers found that the beneficial effects of hydrogen-rich saline treatment were associated with decreased levels of oxidative products (8-iso-prostaglandin F2α and malondialdehyde) and inflammatory cytokines (tumor necrosis factor-α, interleukin-1β, and high-mobility group box protein 1), as well as the increased activity of antioxidant enzymes (superoxide dismutase and catalase) in serum and brain tissues. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats.
In male Sprague-Dawley rats, sTZ-diabetic rats were marked by clearly reduced b-wave amplitudes and oscillatory potentials, DM-related BRB breakdown and histological changes in the inner retina, all of which were suppressed following treatment with hydrogen-rich saline. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreEffects of hydrogen-rich water on depressive-like behavior in mice.
In an animal model, cUMS induced elevation in IL-1β protein levels in the hippocampus, and the cortex was significantly attenuated after 4 weeks of feeding the mice hydrogen-rich water. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreControlled Release of Hydrogen-Carrying Perfluorocarbons for Ischemia Myocardium-Targeting 19 F MRI-Guided Reperfusion Injury Therapy.
In a mouse model of myocardial ischemia-reperfusion, hydrogen-loaded PFOB nanoemulsions accumulated in ischemic heart tissue and showed antioxidant and anti-inflammatory effects; ultrasound-triggered hydrogen release further enhanced the therapeutic response. These results are preclinical and suggest molecular hydrogen's therapeutic potential as a targeted delivery approach. Further human research is needed to establish clinical effectiveness.
Read MoreBeneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits.
In rabbits with spinal-cord ischemia-reperfusion injury, inhaling 2% or 4% H₂ improved hind-limb motor function and motor-neuron preservation and reduced oxidative products, inflammatory cytokines, and neuronal apoptosis. These results are preclinical and suggest molecular hydrogen's therapeutic potential for spinal-cord reperfusion injury. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen: A Potential New Adjuvant Therapy for COVID-19 Patients.
This narrative review proposes that molecular hydrogen's antioxidant and anti-inflammatory actions might help limit cytokine storm, lung injury, and severe disease in COVID-19, but it does not report a new clinical trial. The authors explicitly state that efficacy and safety require large clinical trials and further confirmation.
Read MoreMolecular hydrogen downregulates acute exhaustive exercise-induced skeletal muscle damage.
In sedentary rats running to exhaustion, inhalation of an H₂-containing gas mixture increased exercise-associated SOD activity and blunted lipid peroxidation, inflammatory cytokine surges, NF-κB phosphorylation, and cleaved caspase-3 expression. These results are preclinical and suggest molecular hydrogen's therapeutic potential for limiting acute exhaustive-exercise muscle damage. Further human research is needed to establish clinical effectiveness.
Read MoreInhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice.
In mice exposed to intermittent hypoxia, 1.3% H₂ inhalation suppressed dyslipidemia, myocardial superoxide production, inflammatory gene expression, cardiomyocyte hypertrophy, mitochondrial degeneration, and fibrosis. These results are preclinical and suggest molecular hydrogen's therapeutic potential for cardiac remodeling associated with sleep-apnea-like intermittent hypoxia. Further human research is needed to establish clinical effectiveness.
Read MoreMolecular hydrogen potentiates hypothermia and prevents hypotension and fever in LPS-induced systemic inflammation.
In male Wistar rats with LPS-induced systemic inflammation, 2% H₂ inhalation reduced pro-inflammatory cytokines, increased IL-10, prevented fever, and during severe inflammation prevented hypotension while potentiating hypothermia. These results are preclinical and suggest molecular hydrogen's therapeutic potential for inflammatory and thermoregulatory responses. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen activates ACOD1-itaconate pathway to ameliorate steroid-associated osteonecrosis.
In a glucocorticoid-induced mouse model of steroid-associated osteonecrosis, saturated hydrogen-rich water reduced osteocyte apoptosis and bone resorption, improved trabecular structure, bone formation, blood perfusion, and lipid measures, and shifted macrophage signaling toward an anti-inflammatory profile. These results are preclinical and suggest molecular hydrogen's therapeutic potential for steroid-associated bone injury. Further human research is needed to establish clinical effectiveness.
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