富氢水抑制离心运动后骨骼肌线粒体氧化应激和炎症反应
In Sprague Dawley rats, the study examined whether hydrogen-rich water could protect skeletal muscle from eccentric-exercise injury and explored the underlying mechanisms. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen gas inhalation alleviated cerebral ischemia/reperfusion injury by regulating mitophagy in SH-SY5Y cells and mice via PTEN-induced kinase 1/Parkin pathway.
In SH-SY5Y cells, H₂ treatment significantly improved cell viability, attenuated oxidative stress and mitochondrial dysfunction, and enhanced mitophagy via activation of the PINK1/Parkin pathway. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreInhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice.
Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreNeuroprotective Effects of Molecular Hydrogen via Oxidative Stress and Neuroinflammation Regulation in a 5xFAD Mouse Model.
In the hippocampus, H₂ upregulated nuclear factor erythroid 2-related factor 2 (NRF2), attenuated nuclear factor kappa B (NF-κB) activation, reduced the BAX/BCL-2 ratio, preserved neuronal nuclei (NEUN) expression, and decreased hippocampal Aβ42 burden. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreInhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by Protecting Spinal Cord Neurons from Apoptosis, Oxidative Injury and Mitochondrial Structure Damages.
In mice, spinal cord neurons were preserved by hydrogen administration after mechanical injury in a dose-dependent manner. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through the Activation of PGC-α in Mice.
In mice, the present study showed that hydrogen gas therapy increased the 7-day survival rate, improved cognitive function, increased the mitochondrial function (MMP, ATP level, complex I activity) and expression of mitochondrial biogenesis parameters (PGC-1α, NRF2, Tfam). These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreBiological Responses to Hydrogen Molecule and its Preventive Effects on Inflammatory Diseases.
However, the researchers showed previously that inhalation of H₂ markedly suppresses brain injury induced by focal ischemia-reperfusion by buffering oxidative stress. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read More富氢水抑制离心运动后骨骼肌线粒体氧化应激和炎症反应
In Sprague Dawley rats, the study examined whether hydrogen-rich water could protect skeletal muscle from eccentric-exercise injury and explored the underlying mechanisms. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreTranslational Study of Hydrogen Gas Inhalation as Adjuncts to Reperfusion Therapy for Acute Myocardial Infarction.
This publication is a scientific hypothesis or perspective about molecular hydrogen and identifies directions for further research.
Read MoreMolecular Hydrogen Protects Human Melanocytes from Oxidative Stress by Activating Nrf2 Signaling.
In a laboratory model, initially found that H₂ reduced intracellular ROS accumulation and malondialdehyde levels in both vitiligo specimens and hydrogen peroxide-treated melanocytes in vitro in a concentration- and time-dependent manner, concomitant with the enhancement of antioxidant enzyme activity. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
Read MoreInhalation of molecular hydrogen increases breath acetone excretion during submaximal exercise: a randomized, single-blinded, placebo-controlled study.
H₂ significantly augmented breath acetone and enhanced oxygen uptake during exercise. This source-grounded publication contributes evidence relevant to molecular hydrogen and is retained in a transparent general research category when a more specific study design is not supported by the indexed record.
Read MoreROS-scavenging hydrogen nanotherapy simultaneously targets inflammation and pain in rheumatoid arthritis.
Relieving pain while treating rheumatoid arthritis (RA) is a pressing clinical need to improve satisfaction of patients, which has not received the due attention and solution. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen: A Rising Star in Gas Medicine as a Mitochondria-Targeting Nutrient via Activating Keap1-Nrf2 Antioxidant System.
This narrative review examined the available evidence on molecular hydrogen. The reviewed evidence supports molecular hydrogen's therapeutic potential. Additional well-designed studies are needed to clarify clinical safety and effectiveness.
Read MoreHydrogen: A Novel Option in Human Disease Treatment.
This narrative review examined the available evidence on molecular hydrogen. Clinical experiments have revealed the surprising finding that H₂ gas may protect the lungs and extrapulmonary organs from pathological stimuli in NCP patients. The reviewed evidence supports molecular hydrogen's therapeutic potential. Additional well-designed studies are needed to clarify clinical safety and effectiveness.
Read MoreStimulation of human damaged sperm motility with hydrogen molecule.
In a laboratory model, H₂ treatment significantly improved the rate of forward motility, whereas treatment with nitrogen gas did not. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
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