Mechanism of hydrogen-rich water alleviating radiation-induced cognitive impairment through PI3K/AKT/Caspase-9 pathway mediating anti-oxidation.
In rats, hydrogen-rich water can improve the radiation-induced cognitive impairment in rats induced by ionizing radiation through anti-inflammation, anti-oxidation, and regulation of PI3K/AKT/Caspase-9 pathway, and there is a certain dose-effect relationship. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreInhalation of high-concentration hydrogen gas attenuates cognitive deficits in a rat model of asphyxia induced-cardiac arrest.
In Neuronal degeneration within hippocampal Cornu Ammonis 1 (CA1) regions was examined by Fluoro-Jade staining ex vivo, both hydrogen gas treatment regimens significantly improved spatial learning function and attenuated neuronal degeneration within hippocampal CA1 regions at 18 days post-resuscitation. These findings come from a laboratory model and suggest molecular hydrogen's biological potential. Further research is needed to determine clinical relevance.
Read MoreThe Hydration Equation: Update on Water Balance and Cognitive Performance.
This study examined The Hydration Equation: Update on Water Balance and Cognitive Performance. The abstract reports: Traditionally a 2% or more body water deficit was thought to produce cognitive performance decrements; however, recent literature suggests that even mild dehydration -…. This is an automated editorial draft based on the abstract and requires source review before publication.
Read MoreHydrogen intake relieves alcohol consumption and hangover symptoms in healthy adults: a randomized and placebo-controlled crossover study.
In 1 participants, hydrogen treatment improved cognitive testing scores (P< 0.05), including attention and executive functions. These findings add human evidence supporting molecular hydrogen's therapeutic potential to influence cognitive function in healthy adults.
Read MoreHydrogen applications: advances in the field of medical therapy.
This narrative review examined the available molecular-hydrogen literature. Hydrogen (H₂) has been widely used in the chemical industry as a reducing agent. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreRedox Effects of Molecular Hydrogen and Its Therapeutic Efficacy in the Treatment of Neurodegenerative Diseases
This narrative review examined the available evidence on molecular hydrogen. Redox Effects of Molecular Hydrogen and Its Therapeutic Efficacy in the Treatment of Neurodegenerative Diseases With this, molecular hydrogen (H₂) has been recently reported as an antioxidant and anti-inflammatory agent to treat several oxidative stress-related diseases. The reviewed evidence supports molecular hydrogen's therapeutic potential. Additional well-designed studies are needed to clarify clinical safety and effectiveness.
Read MoreMolecular hydrogen in the treatment of acute and chronic neurological conditions: mechanisms of protection and routes of administration.
This narrative review examined the available molecular-hydrogen literature. Recently, the neuroprotective effects of treatment with molecular hydrogen have been reported in both basic and clinical settings. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreLong-Term Inhalation of Hydrogen Gas for Patients with Advanced Alzheimer’s Disease: A Case Report Showing Improvement in Fecal Incontinence
In 12 patients with COVID-19: A retrospective study of medical records, after the long-term inhalation of H₂ gas, her MRI of the brain to generate DTI images with an anisotropic (FA) value of 0.2 (FA = 0.2) showed improved integrity of the hippocampal neurons along with these clinical improvements. These findings add human evidence supporting molecular hydrogen's therapeutic potential for Alzheimer's disease.
Read MoreRole of Molecular Hydrogen in Ageing and Ageing-Related Diseases.
This narrative review examined the available molecular-hydrogen literature. Hydrogen can also be used for prevention and treatment of various ageing-related diseases, such as neurodegenerative disorders, cardiovascular disease, pulmonary disease, diabetes, and cancer. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreTherapeutic Efficacy of Molecular Hydrogen: A New Mechanistic Insight.
This narrative review examined however, many reports on therapeutic applications of H₂ have the limitation to regard H₂ only as a scavenger for the hydroxyl radical and peroxynitrite. H₂ is proposed to convert the quinone intermediates to the fully reduced ubiquinol, thereby increasing the antioxidant capacity of the quinone pool as well as preventing the generation of ROS. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreHydrogen as an innovative nootropic in health and disease.
This narrative review examined the available molecular-hydrogen literature. Despite the growing interest in H₂ as a potential therapeutic agent, the evidence regarding its potential as a nootropic remains limited. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreNeuroprotective Effects of Molecular Hydrogen: A Critical Review.
This narrative review examined the available molecular-hydrogen literature. Further, H₂ is easy to use and has neuroprotective effects with no major side-effects, indicating that H₂ administration is a potential therapeutic strategy in clinical settings. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read More[Protective effects of inhaled hydrogen gas on cognitive function in mice with sepsis-associated encephalopathy].
In mice, compared with sepsis group, neurological function significantly improved and damaged neurons in hippocampal CA1 region significantly reduced. The activities of SOD and CAT markedly increased and the levels of MDA and 8-iso-PGF2α markedly decreased in sera and hippocampus; the time in new zone and the percentage of freezing time dramatically increased at days 3 to 14 post-operations in sepsis+H₂ group (P < 0.05). These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreNew Treatment for the Cognitive and Emotional Deficits Linked with Paclitaxel-Induced Peripheral Neuropathy in Mice.
Chemotherapy-provoked peripheral neuropathy and its linked comorbidities severely reduce the quality of a patient's life. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreEffects of hydrogen-rich saline on rats with acute carbon monoxide poisoning.
In male Sprague-Dawley rats, h(2)-rich saline treatment improved the cognitive deficits and reduced the degree of necrosis, apoptosis, and cell autophagy in rats. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
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