Emerging Clinical Applications for Molecular Hydrogen.
This narrative review examined the current clinical experience with inhaled H₂ therapy, discusses key challenges and limitations in the existing literature, and identifies areas of interest for future research, including the development of a validated delivery system to enable broader clinical investigation and application of H₂ therapy. Published clinical findings are encouraging, although data are limited by small sample sizes, methodological variability, and the absence of standardized and validated commercially available delivery systems. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read More[Suppression of abdominal aortic aneurysm by hydrogen through chemokine-like factor1].
In male Sprague-Dawley rats, hydrogen which may contribute to reduce rCklf1 expression prevents infiltration of inflammation and expression of MMP2 thus decreasing destruction and degradation of elastic fibers, therefore ameliorates development of AAA. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen Gas Therapy: From Preclinical Studies to Clinical Trials.
This narrative review examined the authors' new method that enables H₂ gas to be easily transported to emergency settings and quickly injected into an organ preservation solution at the site of donor organ procurement have been described. Mounting evidence indicates that hydrogen gas (H₂) is a versatile therapeutic agent, even at very low, non-combustible concentrations. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read More[Hydrogen-rich saline attenuates hyperalgesia and reduces cytokines in rats with post-herpetic neuralgia via activating autophagy].
In rats, compared with PHN group,the rats in the PHN-H₂ group and PHN-H₂-Rap group showed increased PWT,decreased levels of TNF-α,IL-1β and IL-6,further up-regulated expressions of LC3 and beclin 1 as wel as P62 expression. These results are preclinical and suggest molecular hydrogen's therapeutic potential in the condition studied. Further human research is needed to establish clinical effectiveness.
Read MoreHydrogen: A Novel Option in Human Disease Treatment.
This narrative review examined the available molecular-hydrogen literature. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreMechanisms of antioxidative and anti-inflammatory… : Tungs’ Medical Journal
This narrative review examined the available molecular-hydrogen literature. The search strategy included combinations of keywords such as “chronic kidney disease,” “oxidative stress,” “inflammation,” “antioxidant therapy,” “molecular hydrogen,” “H₂ therapy,” and “renal protection.” Articles were screened for relevance based on their titles and abstracts, and those addressing mechanistic insights, preclinical findings, and clinical studies were prioritized. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreInhalation of hydrogen gas attenuates ouabain-induced auditory neuropathy in gerbils.
The results demonstrate that H(2) treatment is beneficial to ouabain-induced AN via reducing apoptosis. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read More[Effects of hydrogen gas on NOD-like receptor protein 3 inflammasomes in the cerebral cortex of rats with traumatic brain injury].
In an animal model, the mechanism by which hydrogen gas alleviates TBI may be related to inhibiting NLRP3 inflammasomes in the cerebral cortex of rats. These preclinical findings add evidence about the molecular-hydrogen effects, outcomes, and biological pathways measured in this model.
Read MoreMolecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation.
This narrative review examined the available molecular-hydrogen literature. Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read More[Improvement of hydrogen on liver oxidative stress injury in chronic intermittent hypoxia rats].
In rats, compared with CIH group, the pathology of liver microstructure were significantly improved and the serum levels of ALT, AST were significantly lower in H₂+CIH group (P<0.05); the serum levels of 8-OHdG and IL-6 were significantly lower, the serum level of SOD was significantly higher. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreMicrobial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing intestinal barrier.
In mice, exogenous H₂ reprograms colonocyte metabolism by regulating the H₂-gut microbiota-SCFAs axis and strengthens the intestinal barrier by modulating specific mucosa-associated mucolytic bacteria, wherein improved microbial hydrogen economy alleviates colitis. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreHydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via miR-124-3p.
In mice, it was also found that compared with the hydrogen-rich saline group, overexpression of calpain1 increased caspase-3 activities, promoted cleaved-caspase3 and Bax protein expressions, and correspondingly decreased Bcl-2, further reducing cell viability. These preclinical findings add evidence supporting molecular hydrogen's therapeutic potential within the outcomes and biological pathways measured in this model.
Read MoreMolecular Hydrogen as a Potential Clinically Applicable Radioprotective Agent.
This narrative review examined the available molecular-hydrogen literature. Molecular hydrogen (H₂) has the potential to be a radioprotective agent because it can selectively scavenge •OH, a reactive oxygen species with strong oxidizing power. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreThe Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury.
This narrative review examined the available molecular-hydrogen literature. In recent years, several studies have provided preliminary evidence for the protective effects of hydrogen on spinal cord injury (SCI). The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
Read MoreHydrogen: An Endogenous Regulator of Liver Homeostasis.
This narrative review examined the available molecular-hydrogen literature. The reviewed evidence adds support for molecular hydrogen's therapeutic potential across the conditions, mechanisms, or outcomes examined.
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